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CAS No.: 1628260-79-6
Synonyms: GLPG1690;ziritaxestat
GLPG1690, a first-in-class autotaxin (ATX) inhibitor with IC50 of 131 nM and Ki of 15 nMl, is able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice, and in reducing extra-cellular matrix deposition in the lung whilst also reducing LPA 18:2 content in bronchoalveolar lavage fluid and may be a possible effectvie compound in treating idiopathic pulmonary fibrosis.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03515382 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Quotient Sciences Limited Ruddington, United Kingdom Collapse << |
NCT02179502 | Healthy | Phase 1 | Completed | - | Belgium ... more >> SGS LSS Clinical Pharmacology Unit Antwerp Antwerp, Belgium Collapse << |
NCT03143712 | Healthy | Phase 1 | Completed | - | Belgium ... more >> SGS CPU Antwerp, Belgium Collapse << |
实验方案
技术信息
CAS号 | 1628260-79-6 | 储存条件 |
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分子式 | C30H33FN8O2S | 运输 | 蓝冰 | |||||
分子量 | 588.70 | 别名 | GLPG1690;ziritaxestat | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03515382 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Quotient Sciences Limited Ruddington, United Kingdom Collapse << |
NCT02179502 | Healthy | Phase 1 | Completed | - | Belgium ... more >> SGS LSS Clinical Pharmacology Unit Antwerp Antwerp, Belgium Collapse << |
NCT03143712 | Healthy | Phase 1 | Completed | - | Belgium ... more >> SGS CPU Antwerp, Belgium Collapse << |
NCT03711162 | Idiopathic Pulmonary Fibrosis | Phase 3 | Recruiting | December 2021 | United States, Arizona ... more >> Pulmonary Associates Recruiting Phoenix, Arizona, United States, 85006 United States, Minnesota Minnesota Lung Center Recruiting Minneapolis, Minnesota, United States, 55407 United States, North Carolina PulmonIx LLC Recruiting Greensboro, North Carolina, United States, 27403 United States, Texas Metroplex Pulmonary and Sleep Medicine Center Recruiting McKinney, Texas, United States, 75069 Collapse << |
NCT03733444 | Idiopathic Pulmonary Fibrosis | Phase 3 | Recruiting | December 2021 | United States, Florida ... more >> St. Francis Medical Institute Recruiting Clearwater, Florida, United States, 33765 Collapse << |
NCT02738801 | Idiopathic Pulmonary Fibrosis | Phase 2 | Completed | - | Ukraine ... more >> Municipal Clinical Hospital # 6 Dnipropetrovsk, Ukraine Kharkov City Clinical Hospital # 13 Kharkov, Ukraine F.G. Yanovskyy Institute of Phthisiatry and Pulmonology 1 Kiev, Ukraine F.G. Yanovskyy Institute of Phthisiatry and Pulmonology 2 Kiev, Ukraine Oesa Regional Clinical Hospital Odesa, Ukraine Poltava Regional Clinical Antituberculosis Dispancery Poltava, Ukraine United Kingdom Royal Brompton Hospital London, United Kingdom The Medicines Evaluation Unit Manchester, United Kingdom Collapse << |
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