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CAS No.: 1943733-16-1

YU238259 Catalog No. CSN21207

Synonyms: YU238259

YU238259 is an inhibitor of homology-dependent DNA repair.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述YU238259 is a novel DNA double-strand break repair inhibitor exhibiting potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically inhibits homology-dependent DNA repair, but not non-homologous end-joining, in cell-based GFP reporter assays at concentration of 5μM. Treatment with YU238259 was not only synergistic with ionizing radiation, etoposide, and PARP inhibition, but this synergism was heightened by BRCA2 deficiency. Also it significantly delayed growth of BRCA2-deficient human tumor xenografts in nude mice through administration at dose of 3mg/kg, i.p., 3 days per week for 12 doses, even in the absence of concomitant DNA-damaging therapy.
动物研究
剂量
Mice: 3 mg/kg, 5 mg/kg^[1] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 3 mg/kg, 5 mg/kg^[1] (i.p.)
给药途径	i.p.

[1] Stachelek GC, Peterson-Roth E, et al. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors. Mol Cancer Res. 2015 Oct;13(10):1389-97.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1742 mL
- 10.8708 mL
- 21.7417 mL
- 5 mM
- 0.4348 mL
- 2.1742 mL
- 4.3483 mL
- 10 mM
- 0.2174 mL
- 1.0871 mL
- 2.1742 mL

技术信息

CAS号

1943733-16-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H22ClN3O4S

运输

蓝冰

分子量

459.95

别名

YU238259

溶解度

DMSO	50.0 mg/mL (108.7 mM)
Water	insoluble

动物实验配方

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