生物活性

• 靶点	Adrenergic Receptor α2B EC50:99μM

• 描述Xylometazoline hydrochloride is used as nasal mucosa decongesting α-adrenoceptor agonists during a common cold^[2]. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time^[3]. Using the decongestant efficacy provided by xylometazoline HCl(Hydrochloride) and the effectiveness to reduce viral infection accomplished by iota-carrageenan can combine into a new product^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01971762	-	-	Completed	-	Spain ... more >> Hospital de Puerto Real Puerto Real, Cádiz, Spain Hospital Costa del Sol Marbella, Málaga, Spain Hospital de Torrecárdenas Almería, Spain Hospital de barcelona - SCIAS Barcelona, Spain Hospital de Cruces Bilbao, Spain Hospital Puerta del Mar Cádiz, Spain Hospital Reina Sofía Córdoba, Spain Hospital Virgen de las Nieves Granada, Spain Hospital Juan Ramón Jiménez Huelva, Spain Hospital de San Pedro Logroño, Spain Hospital de la Arrixaca Murcia, Spain Hospital Carlos Haya Málaga, Spain Hospital Virgen de la Victoria Málaga, Spain Hospital de Valdecillas Santander, Spain Hospital Universitario Virgen de la Macarena Sevilla, Spain Hospital Virgen de Valme Sevilla, Spain Collapse <<
  NCT03323684	Laparoscopic Cholecystectomy	Not Applicable	Completed	-	Egypt ... more >> Mansoura University, Faculty of Medicine Mansourah, DK, Egypt, 050 Mansoura University Mansourah, DK, Egypt, 050 Collapse <<
  NCT01819597	Intracranial Arterial Stenosis... more >> Intracranial Atherosclerosis Ischemic Stroke Cerebral Angiogenesis Collapse <<	Phase 2	Recruiting	June 2018	United States, California ... more >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Nestor R Gonzalez, MD, FAHA    310-423-0783    nestor.gonzalez@cshs.org    Contact: Antoinette Anderson    310-423-0783    antoinette.anderson@cshs.org    Principal Investigator: Nestor R Gonzalez, MD          Sub-Investigator: Jeffrey Saver, MD          Sub-Investigator: Patrick Lyden, MD          Sub-Investigator: Konrad Schlick, MD          Sub-Investigator: Shlee Song, MD          Sub-Investigator: Michael Alexander, MD          Sub-Investigator: Wouter Schievink, MD          Sub-Investigator: Oana Dumitrascu, MD Collapse <<

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• 参考文献

• [1] Haenisch B, Walstab J, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

  [2] Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bönisch H. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x. PMID: 20030735.

  [3] Eccles R, Eriksson M, Garreffa S, Chen SC. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6. doi: 10.2500/ajr.2008.22.3202. Epub 2008 Jul 24. PMID: 18655753.

  [4] Graf C, Bernkop-Schnürch A, Egyed A, Koller C, Prieschl-Grassauer E, Morokutti-Kurz M. Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis. Int J Gen Med. 2018 Jul 4;11:275-283. doi: 10.2147/IJGM.S167123. PMID: 30013382; PMCID: PMC6037157.