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CAS No.: 725247-18-7

XCT790 Catalog No. CSN16334

Synonyms: Compound 12

XCT-790 is an agonist of estrogen related receptor alpha (ERRα) and can induce death of cancer cells resistant to chemotherapy.

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技术信息

生物活性

描述The estrogen-related receptor α (ERRα) is an orphan nuclear receptor that can be regulated by peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1). XCT790 is a selective inverse agonist for ERRα with an IC50 value of 0.37 μM, but displays no activity against ERRγ and estrogen receptors ERα and ERβ^[3]. XCT-790 at 5 – 20 μM reduced the viability of HepG2 and R-HepG2 cells in a dose-dependent manner. The treatment of HepG2 and R-HepG2 cells with XCT-790 (10 μM) for 24 h reduced the protein levels of ERRα and decreased mitochondrial masses as compared to the DMSO-treated control group^[4]. In mice inoculated with H295R adrenocortical cancer cells, the administration of XCT790 (2.5 mg/kg) for 21 days decreased H295R cell proliferation and suppressed tumor growth compared to the vehicle-treated group^[5].
作用机制XCT790 is a thiadiazoleacrylamide that functions as a potent inverse agonist of ERRα^[3].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6767 mL
- 8.3833 mL
- 16.7666 mL
- 5 mM
- 0.3353 mL
- 1.6767 mL
- 3.3533 mL
- 10 mM
- 0.1677 mL
- 0.8383 mL
- 1.6767 mL

技术信息

CAS号

725247-18-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H13F9N4O3S

运输

蓝冰

分子量

596.42

别名

Compound 12

溶解度

DMSO	8.0 mg/mL (13.4 mM)
Water	Insoluble
Ethanol	Insoluble

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XCT790 Catalog No. CSN16334

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