1421227-53-3|WS6|CsnPharm

CAS No.: 1421227-53-3

WS6 Catalog No. CSN16939

Synonyms: WS6

WS6 is a small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 μM (R7T1 cell viability). WS6 also stimulates α cell proliferation in human pancreatic islets. WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.

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实验方案

技术信息

生物活性

描述WS6 is a novel small molecule that promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability). EC50 value: 0.28 uM. RIP-DTA mice were fed Dox in the drinking water until the onset of overt diabetes (blood glucose reading >300 mg/dL, typically 4-10 days), at which point Dox treatment was discontinued and treatment with WS6 was initiated (5 mg/kg every other day via intraperitoneal injection). Pharmacokinetic studies with WS6 at 50 mg/kg revealed a CMAX of ～5 μM and T1/2 of ～2 h. Treatment with WS6 caused a progressive reduction of blood glucose over time, starting around 2 weeks^[3]. Enhancement of human β-cell proliferation is one potential approach to restore β-cell mass to prevent and/or cure type 1 and type 2 diabetes. WS6, an IkB kinase and EBP1 inhibitor, can promote effective human β-cell proliferation^[4]. WS6 did not change the proportion of insulin-positive beta cells or the expression of beta cell-specific transcription factors, suggesting that WS6 does not alter beta cell differentiation, and WS6 had no effect on human islet cell apoptosis or viability^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7587 mL
- 8.7937 mL
- 17.5874 mL
- 5 mM
- 0.3517 mL
- 1.7587 mL
- 3.5175 mL
- 10 mM
- 0.1759 mL
- 0.8794 mL
- 1.7587 mL

技术信息

CAS号

1421227-53-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H31F3N6O3

运输

蓝冰

分子量

568.59

别名

WS6

溶解度

DMSO	370.0 mg/mL (650.7 mM)
Water	insoluble

动物实验配方

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WS6 Catalog No. CSN16939

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