162760-96-5|WAY-100635|CsnPharm

CAS No.: 162760-96-5

WAY-100635 Catalog No. CSN16799

Synonyms: WAY-100635

WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71, an IC50 of 0.91 nM and Ki of 0.39 nM^[3]. Exposure of h5-HT(1A) CHO cells to WAY-100635 decreased the cell-surface h5-HT(1A) receptor density in a way that was both time (24-72 h) and concentration (1-100 nM) dependent^[4]. WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat^[5]. The intra-hippocampus and intra-BLA injections of WAY-100635 improved the delirium-like behavior of rats by significantly reducing the expression of NLRP3 inflammasome and the release of IL1-β and IL8 into CSF (cerebrospinal fluid)^[6]. WAY-100635 may influence some of the anxiolytic-relaxant effects of BEO (bergamot essential oil) in Open Field and Elevated Plus Maze tests^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00603018	-	-	Completed	-	-
NCT00603018	Anorexia Nervosa	Not Applicable	Completed	-	United States, Pennsylvania ... more >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT00922064	Unipolar Depression	Phase 4	Completed	-	Austria ... more >> Medical University of Vienna, Dept. of Psychiatry and Psychotherapy Vienna, Austria, 1090 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3665 mL
- 11.8326 mL
- 23.6651 mL
- 5 mM
- 0.4733 mL
- 2.3665 mL
- 4.7330 mL
- 10 mM
- 0.2367 mL
- 1.1833 mL
- 2.3665 mL

技术信息

CAS号	162760-96-5	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C25H34N4O2	运输	蓝冰
分子量	422.56	别名	WAY-100635

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00603018	-	-	Completed	-	-
NCT00603018	Anorexia Nervosa	Not Applicable	Completed	-	United States, Pennsylvania ... more >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT00922064	Unipolar Depression	Phase 4	Completed	-	Austria ... more >> Medical University of Vienna, Dept. of Psychiatry and Psychotherapy Vienna, Austria, 1090 Collapse <<
NCT02810717	Treatment Resistant Depression	Not Applicable	Recruiting	November 2019	Austria ... more >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, A-1090 Contact: Siegfried Kasper, MD, Prof. +43-1-40400-3568 sci-biolpsy@meduniwien.ac.at Collapse <<
NCT02359513	Bulimia Nervosa	Phase 4	Recruiting	March 2020	France ... more >> Groupement Hospitalier Est - HCL Recruiting Bron, France, 69678 Contact: Mohamed SAOUD, PhD (0)472118064 ext +33 mohamed.saoud@ch-le-vinatier.fr Principal Investigator: Mohamed SAOUD, PhD Sub-Investigator: Sylvain ICETA, MD Sub-Investigator: Bérénice SEGRESTIN, MD CHU Grenoble Recruiting Grenoble, France, 38043 Contact: Claire BUIS, MD Principal Investigator: Claire BUIS, MD Sub-Investigator: Thierry BOUGEROL, MD PhD Chu Saint-Etienne Recruiting Saint-Etienne, France, 42055 Contact: Bogdan GALUSCA, MD 0477127594 ext +33 bogdan.galusca@chu-st-etienne.fr Contact: Torrance SIGAUD, MD Principal Investigator: Bogdan GALUSCA, MD Sub-Investigator: Torrance SIGAUD, MD Sub-Investigator: Catherine MASSOUBRE, PU-PH Sub-Investigator: Bruno ESTOUR, PU-PH Sub-Investigator: Natacha GERMAIN, PU-PH Collapse <<
NCT00435695	Healthy Subjects ... more >> Depressive Disorder and Anxiety Disorders Collapse <<	Phase 1	Completed	-	Canada, Ontario ... more >> GSK Investigational Site Toronto, Ontario, Canada, M5T 1R8 Collapse <<

WAY-100635 Catalog No. CSN16799

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