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CAS No.: 42971-09-5

Vinpocetine/长春西汀 Catalog No. CSN12204

Synonyms: Ethyl apovincaminate;RGH-4405;Apovincaminic Acid ethyl ester

Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 μM, it also blocks voltage-gated Na+ channels. It's a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 PDE1

IC50:21μM
描述Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders^[3]. Vinp inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB)-dependent inflammatory responses and oxidative damage in which osteoclasts are often involved^[4]. In both in vivo and in vitro experiments, vinpocetine can confer protection of rat renal cells by inhibiting the NF-κB signaling pathway and activating the Nrf2/ARE signaling pathway^[5]. Vinpocetine potently suppressed tumor necrosis factor-α-induced nuclear factor kappa-light-chain-enhancer of activated B cells activation and proinflammatory mediator expression in primary cultured macrophages in vitro, as well as in the aorta wall in vivo, suggesting vinpocetine conferred anti-AAA (Abdominal aortic aneurysm) effect at least partially via the inhibition of inflammation^[6]. Vinpocetine treatment may exhibit anti-inflammatory activity and alleviate cognitive impairment^[7]. The effects of vinpocetine might be attributed not only to its antioxidant and anti-inflammatory properties, but also to its suppressing effect on GSK3β (Glycogen synthase kinase-3β) activity and its downstream BACE1(β-secretase) ^[8].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00719953	-	-	Completed	-	-
NCT00719953	Elderly Memor... more >>y Impairment Collapse <<	Phase 4	Completed	-	Israel ... more >> Suorasky Medical Center Tel-Aviv, Israel Collapse <<
NCT01515839	Traumatic Brain Injury	Not Applicable	Completed	-	United States, California ... more >> Amen Clinics, Inc. Newport Beach, California, United States, 92660 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8534 mL
- 14.2672 mL
- 28.5344 mL
- 5 mM
- 0.5707 mL
- 2.8534 mL
- 5.7069 mL
- 10 mM
- 0.2853 mL
- 1.4267 mL
- 2.8534 mL

技术信息

CAS号

42971-09-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H26N2O2

运输

蓝冰

分子量

350.45

别名

Ethyl apovincaminate;RGH-4405;Apovincaminic Acid ethyl ester;AY 27255;AY-27,255;TCV-3B;Cavinton;Intelectol;长春西汀

溶解度

DMSO	insoluble
Water	insoluble
Ethanol	5.0 mg/mL (14.3 mM) warming

动物实验配方

0.5% CMC-Na

32 mg/mL

suspension

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