生物活性

• 描述Vapreotide, a synthetic analog of somatostatin, has NK1R antagonist activity.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00331188	Esophageal Varices ... more >> Portal Hypertension Gastric Varices Esophageal Bleeding Collapse <<	Phase 3	Completed	-	-
  NCT00014651	Pancreatic Cancer ... more >> Perioperative/Postoperative Complications Collapse <<	Phase 3	Terminated(Teminated by the DS... more >>MB because there are no differences between the control group and the Vapreotide group) Collapse <<	-	United States, Alabama ... more >> University of Alabama Comprehensive Cancer Center Birmingham, Alabama, United States, 35294 United States, Florida Moffett Cancer Center (South) Tampa, Florida, United States, 33601 United States, Illinois Rush-Presbyterian-St. Luke's Medical Center Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637 Loyola University Medical Center Maywood, Illinois, United States, 60153 United States, Maryland Johns Hopkins Oncology Center Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan Taubman Health Care Center Ann Arbor, Michigan, United States, 48109 Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 United States, New York NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Pennsylvania University of Pennsylvania Cancer Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555-1329 University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 United States, Washington Virginia Mason Medical Center Seattle, Washington, United States, 98111 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Collapse <<

• 参考文献

• [1] Patel YC, Srikant CB. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology. 1994 Dec;135(6):2814-7.

  [2] Karashima T, Cai RZ, et al. Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release. Life Sci. 1987 Aug 24;41(8):1011-9. Erratum in: Life Sci 1987 Sep 28;41(13):1665.