生物活性

• 描述Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor showing broad-spectrum inhibitor, notably restoring the activity of carbapenems against KPC-producing strains.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02168946	Urinary Tract Infection Compli... more >>cated Acute Pyelonephritis Hospital Acquired Bacterial Pneumonia Ventilator-associated Bacterial Pneumonia Bacteremia Abdominal Infection Collapse <<	Phase 3	Completed	-	-
  NCT02687906	Bacterial Infections	Phase 1	Recruiting	September 2019	United States, Arkansas ... more >> Arkansas Children's Hospital Recruiting Little Rock, Arkansas, United States, 72202 Contact: Robin Gibson, RN    501-364-1542    GibsonRobinA@uams.edu    Principal Investigator: Jose R. Romero, MD          United States, California Ronald Reagan UCLA Medical Center Recruiting Los Angeles, California, United States, 90095 Contact: Elizabeth Lang       ELang@mednet.ucla.edu    Principal Investigator: Jaime Deville, MD          Children's Hospital of Orange County Recruiting Orange, California, United States, 92868 Contact: Claudia Enriquez    714-509-4064    cenriquez@choc.org    Principal Investigator: Antonio Arrieta, MD          Rady Children's Hospital San Diego Recruiting San Diego, California, United States, 92123 Contact: Mike Farrell, RN    858-966-8381    mfarrell@rchsd.org    Contact: Sara Hingtgen, RN    858-966-8381    shingtgen@rchsd.org    Principal Investigator: John Bradley, MD          Los Angeles Biomedical Research Institute Withdrawn Torrance, California, United States, 90502 United States, Illinois Ann & Robert H. Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60614 Contact: Laura Fearn       LFearn@luriechildrens.org    Principal Investigator: William Muller, M.D.          United States, Nebraska University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198-2162 Contact: Kristin Malone    402-559-2977    Kristin.malone@unmc.edu    Principal Investigator: Kari Simonsen, MD          United States, New Jersey Rutgers Robert Wood Johnson Hospital Recruiting New Brunswick, New Jersey, United States, 08901 Contact: Lisa Cerrachio       Lisa.Cerrachio@rutgers.edu    Principal Investigator: Sunanda Gaur, MD          United States, Ohio Rainbow Babies and Childrens Hospital Completed Cleveland, Ohio, United States, 44106 Toledo Children's Hospital Completed Toledo, Ohio, United States, 43606 Collapse <<
  NCT03564158	Healthy	Phase 1	Active, not recruiting	December 31, 2018	United States, Maryland ... more >> Pharmaron Cpc, Inc Baltimore, Maryland, United States, 21201 Collapse <<

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• 参考文献

• [1] Griffith DC, Loutit JS, et al. Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6326-32.

  [2] Castanheira M, Rhomberg PR, et al. Effect of the β-Lactamase Inhibitor Vaborbactam Combined with Meropenem against Serine Carbapenemase-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5454-8.