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CAS No.: 1532533-67-7
Synonyms: TGR-1202;RP5264
RP-5264 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.
生物活性
靶点 | PI3Kδ EC50:24.3nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03269669 | Grade 1 Follicular Lymphoma ... more >> Grade 2 Follicular Lymphoma Grade 3a Follicular Lymphoma Recurrent Follicular Lymphoma Refractory Follicular Lymphoma Collapse << | Phase 2 | Recruiting | December 31, 2022 | - |
NCT03776864 | Hodgkin's Lymphoma | Phase 2 | Not yet recruiting | November 1, 2022 | United States, Washington ... more >> Fred Hutch/University of Washington Cancer Consortium Not yet recruiting Seattle, Washington, United States, 98109 Contact: Ryan Lynch 206-606-1739 rclynch@washington.edu Collapse << |
NCT02874404 | Recurrent Diffuse Large B-Cell... more >> Lymphoma Refractory Diffuse Large B-Cell Lymphoma Collapse << | Phase 2 | Active, not recruiting | August 30, 2021 | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
实验方案
技术信息
CAS号 | 1532533-67-7 | 储存条件 |
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分子式 | C31H24F3N5O3 | 运输 | 蓝冰 | |||||||||||||
分子量 | 571.55 | 别名 | TGR-1202;RP5264 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03269669 | Grade 1 Follicular Lymphoma ... more >> Grade 2 Follicular Lymphoma Grade 3a Follicular Lymphoma Recurrent Follicular Lymphoma Refractory Follicular Lymphoma Collapse << | Phase 2 | Recruiting | December 31, 2022 | - |
NCT03776864 | Hodgkin's Lymphoma | Phase 2 | Not yet recruiting | November 1, 2022 | United States, Washington ... more >> Fred Hutch/University of Washington Cancer Consortium Not yet recruiting Seattle, Washington, United States, 98109 Contact: Ryan Lynch 206-606-1739 rclynch@washington.edu Collapse << |
NCT02874404 | Recurrent Diffuse Large B-Cell... more >> Lymphoma Refractory Diffuse Large B-Cell Lymphoma Collapse << | Phase 2 | Active, not recruiting | August 30, 2021 | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
NCT02867618 | Hodgkin Disease ... more >> Lymphoma, Non-hodgkin Collapse << | Phase 1 Phase 2 | Recruiting | August 2019 | United States, New York ... more >> Columbia Univerity Medical Center - Center for Lymphoid Malignancies Recruiting New York, New York, United States, 10019 Contact: Aisha Banks 212-326-5726 ab3696@cumc.columbia.edu Contact: Celeste Rojas 212-326-5736 cr2393@cumc.columbia.edu Principal Investigator: Changchun Deng, M.D., PhD Collapse << |
NCT02268851 | Chronic Lymphocytic Leukemia/S... more >>mall Lymphocytic Lymphoma Mantle Cell Lymphoma Collapse << | Phase 1 | Active, not recruiting | October 2020 | United States, California ... more >> Pacific Cancer Care Monterey, California, United States, 93940 United States, Connecticut St. Francis Hospital and Cancer Center Hartford, Connecticut, United States, 06105 United States, Maine Eastern Maine Medical Center Brewer, Maine, United States, 04412 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconness Medical Center Boston, Massachusetts, United States, 02215 United States, Michigan West Michigan Cancer Center Kalamazoo, Michigan, United States, 49007 Collapse << |
靶点 | Description | IC50 |
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PI3Kδ | EC50:24.3nM |
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