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CAS No.: 1310693-92-5
Synonyms: Tubastatin A HCl;TSA HCl;Tubastatin A hydrochloride
Tubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
生物活性
实验方案
技术信息
CAS号 | 1310693-92-5 | 储存条件 |
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分子式 | C20H22ClN3O2 | 运输 | 蓝冰 | |||||||||||
分子量 | 371.86 | 别名 | Tubastatin A HCl;TSA HCl;Tubastatin A hydrochloride | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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134/04 | 7.5 µM | Function assay | - | impairs myotube formation | 22174839 |
293T | ~2 μg/ml | Function assay | - | induces PTEN expression and membrane translocation | 26279303 |
293T | ~2 μg/ml | Function assay | - | induces PTEN acetylation at K163 | 26279303 |
C2C12 | 7.5 µM | Function assay | - | impairs myotube formation | 22174839 |
CaSki | ~5 μM | Function assay | - | induces the differential α-tubulin acetylation | 23698468 |
CaSki | ~5 μM | Function assay | - | inhibits Thapsigargin- or EGF-induced SOCE activation | 23698468 |
CML-T1 | 10 μM | Function assay | - | enhances cell adhesivity to fibronectin | 23022583 |
HaCaT keratinocytes | 10 μM | Function assay | - | blocks arsenite from inducing Nrf2 protein translation | 22367689 |
HEK293T | ~3 μM | Function assay | - | up-regulated XBP1s protein level | 24909686 |
HEK293T | ~3 μM | Function assay | - | delays XBP1s protein degradation via acetylation-mediated proteasomal degradation | 24909686 |
HL-60 | 10 μM | Function assay | - | enhances cell adhesivity to fibronectin | 23022583 |
HT3 | ~5 μM | Function assay | - | induces the differential α-tubulin acetylation | 23698468 |
Huh7 | ~5 μM | Function assay | - | suppresses proliferation of hepatitis C virus replicon with EC50 = 0.3 μM | 25108326 |
IPC298 | ~3 μM | Function assay | - | augments expression of MHC class I and melanoma associated antigens | 25957812 |
JURL-MK1 | 10 μM | Function assay | - | enhances cell adhesivity to fibronectin | 23022583 |
K562 | 10 μM | Function assay | - | enhances cell adhesivity to fibronectin | 23022583 |
KMCH | ~10 μM | Growth inhibitory assay | - | decreases proliferation and anchorage-independent growth | 23370327 |
MCF-7 | 30 μM | Growth inhibitory assay | - | IC50=15 μM | 23798680 |
MCF-7 | 30 μM | Function assay | - | increases the microtubule acetylation level. | 23798680 |
MCF-7 | 30 μM | Function assay | - | stabilizes microtubules against cold-induced depolymerization | 23798680 |
MCF-7 | 15 μM | Function assay | - | stabilizes microtubules against nocodazole-induced disassembly | 23798680 |
MCF-7 | 30 μM | Function assay | - | alteres the assembly dynamics of interphase microtubules | 23798680 |
MCF-7 | 30 μM | Function assay | - | increases the binding of HDAC6 with interphase microtubules | 23798680 |
neuron cultures | 2.5 μM | Kinase assay | - | induces α-tubulin hyperacetylation | 20614936 |
neuron cultures | ~10 μM | Function assay | - | protects against glutathione depletion-induced oxidative stress | 20614936 |
PC12 | ~3 μM | Function assay | - | up-regulates anti-oxidative gene expression related to transcription factor XBP1s | 24909686 |
PC12 | ~3 μM | Growth inhibitory assay | - | reverse H2O2-induced growth inhibition | 24909686 |
RAW 264.7 | ~10 μM | Function assay | - | attenuates NO production | 23541634 |
SACC-83 | ~2 μg/ml | Function assay | - | induces PTEN expression and membrane translocation | 26279303 |
SiHa | ~5 μM | Function assay | - | induces the differential α-tubulin acetylation | 23698468 |
SiHa | ~5 μM | Function assay | - | inhibits Thapsigargin- or EGF-induced SOCE activation | 23698468 |
SKMEL103 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
SKMEL21 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
SKMEL28 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
SKMEL30 | ~3 μM | Function assay | - | augments expression of MHC class I and melanoma associated antigens | 25957812 |
TCa83 | - | Function assay | - | induces PTEN expression and membrane translocation | 26279303 |
THP-1 | ~10 μM | Function assay | - | inhibits TNF-α and IL-6 secretion | 23541634 |
U-87 MG | ~2 μg/ml | Function assay | - | inhibits the migration and invasion | 26279303 |
U-87 MG | ~10 μM | Function assay | - | inhibits AKT phosphorylation | 26279303 |
U-87 MG | ~10 μM | Growth inhibitory assay | - | inhibits cell growth | 26279303 |
WM1361a | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM1366 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM164 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM164 | ~6 μM | Function assay | - | induce G1 arrest | 25957812 |
WM164 | ~3 μM | Function assay | - | augments expression of MHC class I and melanoma associated antigens | 25957812 |
WM35 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM793 | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM793 | ~6 μM | Function assay | - | induce G1 arrest | 25957812 |
WM983a | ~500 nM | Growth inhibitory assay | - | inhibits cell proliferation | 25957812 |
WM983a | ~6 μM | Function assay | - | induce G1 arrest | 25957812 |
WM983a | ~3 μM | Function assay | - | augments expression of MHC class I and melanoma associated antigens | 25957812 |
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