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CAS No.: 1252003-15-8
Synonyms: Tubastatin A
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM and is selective(1000-fold more) against all other isozymes except HDAC8(57-fold more).
生物活性
靶点 | HDAC6 IC50:15nM |
动物研究 | |
剂量 | Mice[8] (i.p.): 10 mg/kg - 100 mg/kg |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 1252003-15-8 | 储存条件 |
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分子式 | C20H21N3O2 | 运输 | 蓝冰 | |||||||||||||
分子量 | 335.40 | 别名 | Tubastatin A | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human HeLa cells | - | Function assay | 6 h | Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assay, IC50=2.5 μM. | 25454270 |
human Jurkat cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay, IC50=3.38 μM. | 24304348 |
human KB cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human KB cells after 72 hrs by MTS assay, IC50=14.81 μM. | 25899338 |
human LNCAP cells | - | Cytotoxic assay | 72 h | Cytotoxicity against androgen-dependent human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay, IC50=10.88 μM. | 24304348 |
mouse B16 cells | - | Growth inhibition assay | - | Growth inhibition of mouse B16 cells incubated for 48 hrs by MTT assay, GI50=40.5 μM. | 23009203 |
Sf9 cells | - | Function assay | - | Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate, IC50=15 nM. | 23009203 |
靶点 | Description | IC50 |
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HDAC6 | IC50:15nM |
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