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CAS No.: 555-45-3

TRIMYRISTIN/三肉豆蔻酸甘油酯 Catalog No. CSN23311

Synonyms: 1,2,3-Trimyristoyl Glycerol;Glycerol Tritetradecanoate;Myristic Acid Triglyceride

Trimyristin is used as a lipophilic and nanoparticles carriers loaded with proteins. It is triacylglycerol of myristic acid found in nutmeg.

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400-920-2911

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技术信息

生物活性

描述Trimyristin is used as a lipophilic and nanoparticles carriers loaded with proteins. It is triacylglycerol of myristic acid found in nutmeg. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively^[1]. Trimyristin caused significant rises in low-density lipoprotein (LDL) cholesterol which were accompanied by significant reductions in hepatic LDL receptor mRNA levels^[2]. In hamsters fed high fat diets enriched in trimyristin, tripalmitin or tristearin, increased dietary cholesterol content was associated with increased plasma concentrations of very low density lipoprotein (VLDL) cholesterol and triacylglycerol^[3].
参考文献

[1] Jaiswal P, Kumar P, Singh VK, Singh DK. Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata. Enzyme Res. 2010;2010:478746
[2] Bennett AJ, Billett MA, Salter AM, Mangiapane EH, Bruce JS, Anderton KL, Marenah CB, Lawson N, White DA. Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein. Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):167-73
[3] Bennett AJ, Bruce JS, Salter AM, White DA, Billett MA. Hepatic microsomal triglyceride transfer protein messenger RNA concentrations are increased by dietary cholesterol in hamsters. FEBS Lett. 1996 Oct 7;394(3):247-50

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3828 mL
- 6.9141 mL
- 13.8282 mL
- 5 mM
- 0.2766 mL
- 1.3828 mL
- 2.7656 mL
- 10 mM
- 0.1383 mL
- 0.6914 mL
- 1.3828 mL

技术信息

CAS号

555-45-3

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H86O6

运输

蓝冰

分子量

723.16

别名

1,2,3-Trimyristoyl Glycerol;Glycerol Tritetradecanoate;Myristic Acid Triglyceride;NSC 4062;TG(14:0/14:0/14:0);Tritetradecanoyl Glycerol;三肉豆蔻酸甘油酯;肉豆蔻酸甘油三酯

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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TRIMYRISTIN/三肉豆蔻酸甘油酯 Catalog No. CSN23311

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