|2,2,2-三溴乙醇|CsnPharm

CAS No.: 75-80-9

Tribromoethyl alcohol/三溴乙醇 Catalog No. CSN18684

Synonyms: Narcolan;TBE;Tribromoethanol

2,2,2-Tribromoethanol is used as an injectable anesthetic agent in mice.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述2,2,2-Tribromoethanol is an injectable anesthetic agent used in mice.
Protocol (from Department of Laboratory Animal Resources of the University of Toledo)
1. Stock solution Add 5 ml T-amyl alcohol to 5 g tribromoethanol, (tbe), in a dark bottle to make a 100% stock solution. Shake or stir gently until the solid is dissolved. Stock solution is light sensitive and evaporates rapidly. Do not leave the bottle open longer than is necessary. Label, date and refrigerate in tightly sealed, dark bottle. Yellowing of the solution indicates toxic degradation products and the stock must be replaced. Otherwise, unused stock solution should be discarded after 6 months.
2. Working solution Mix 0.1 ml stock solution with approximately 7.9 ml normal saline, (or PBS), in a glass vessel, (i.e., a graduated cylinder wrapped in foil or a dark bottle). Seal container, heat to improve solubility, and mix well by vortexing until dissolved. (Filter sterilization through 0.2 micron filter is recommended.) Label, date and refrigerate when not in use. (Leave out of refrigerator for approximately one hour prior to administration.) Unused working solution should be discarded after one month.
3. Dosage and Anesthetic Effects The working solution is administered intraperitoneally at 0.4-0.8 ml/mouse, (approximately 0.2 ml/10 grams of body weight). (Inadvertent intravenous injection will cause death within minutes. ) It will take about five minutes for the mouse to become fully anesthetized, (evidenced by lack of response to toe or tail pinch). An additional 0.05-0.1 ml can be given to effect, allowing sufficient time after administering the additional anesthetic to observe the effect. Note that the effective dosage is dependent upon the weight of the mouse. Older, fatter or lactating mice will need more anesthetic to become fully anesthetized. The mouse will remain anesthetized for approximately 30-60 minutes and recover within 1-2 hours. Anesthetized animals should be kept warm for the duration of anesthesia, including surgery.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00224484	Herpes Simplex	Phase 3	Completed	-	-
NCT00276510	Memory Disorders, Age-Related ... more >> Retention Disorders, Cognitive Collapse <<	Phase 4	Completed	-	-
NCT00549770	Hypertension	Phase 2	Completed	-	-

更多
参考文献

[1] Hill WA, Tubbs JT, et al. Repeated administration of tribromoethanol in C57BL/6NHsd mice. J Am Assoc Lab Anim Sci. 2013 Mar;52(2):176-9.
[2] Zeller W, Meier G, et al. Adverse effects of tribromoethanol as used in the production of transgenic mice. Lab Anim. 1998 Oct;32(4):407-13.
[3] Guidelines for the Use of Tribromoethanol/Avertin Anesthesia

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5366 mL
- 17.6828 mL
- 35.3657 mL
- 5 mM
- 0.7073 mL
- 3.5366 mL
- 7.0731 mL
- 10 mM
- 0.3537 mL
- 1.7683 mL
- 3.5366 mL

技术信息

CAS号

75-80-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C2H3Br3O

运输

蓝冰

分子量

282.76

别名

Narcolan;TBE;Tribromoethanol;Tribromoethyl Alcohol;NSC-2189;三溴乙醇;2,2,2-Tribromoethanol

溶解度

Ethanol

125.0 mg/mL (442.1 mM)

动物实验配方

10% Ethanol + 90% water

12.5 mg/mL

clear

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Tribromoethyl alcohol/三溴乙醇 Catalog No. CSN18684

靶点选择性

请登录您的专属账户

确认信息