CAS No.: 1222780-33-7
TPPU Catalog No. CSN23555
Synonyms: TPPU
TTPU is an inhibitor of epoxide hydrolase (sEH) with IC50 of 3.7 nM with anti-inflammatory and anti-atherosclerotic activities.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Rose TE, Morisseau C, Liu JY, et al. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem. 2010;53(19):7067-7075. doi:10.1021/jm100691c
- [2] Ulu A, Appt S, Morisseau C, et al. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol. 2012;165(5):1401-1412. doi:10.1111/j.1476-5381.2011.01641.x
- [3] Wan D, Yang J, McReynolds CB, et al. In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Front Pharmacol. 2019;10:464. doi:10.3389/fphar.2019.00464
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1222780-33-7 | 储存条件 |
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| 分子式 | C16H20F3N3O3 | 运输 | 蓝冰 | |||||
| 分子量 | 359.34 | 别名 | TPPU | |||||
| 溶解度 |
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动物实验配方 |
