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CAS No.: 13850-16-3

Tormentic acid/2Α,19Α-二羟基熊果酸 Catalog No. CSN14489

Synonyms: Tormentic Acid;Tormentolic Acid;Jacarandic acid

Tormentic acid, a natural product isolated and purified from the herb of Potentilla tormentilla with anti-allodynic, anti-inflammatory, anticancer,anti-atherogenic activities, has protective effect against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice.

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生物活性

描述Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties. Tormentic acid inhibits LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages^[3]. Tormentic acid significantly supresses the proliferation of HeLa cells in dose dependence. Tormentic acid also induced remarkable morphological changes in HeLa cells, indicative of apoptosis. Tormentic acid induced G2/M phase cell cycle arrest and its effectiveness increased with increased doses. The expression of tormentic acid on mTOR/PI3K/AKT pathway revealed blocking of this pathway with a concentration-dependent manner^[4]. Intraperitoneal administration of TA (Tormentic acid) attenuated memory deficits in amyloid β precursor protein/presenilin 1 transgenic mice, with a marked decrease in amyloid plaque deposition. TA also reduced microglial activation and decreased the secretion of pro‑inflammatory factors in AD mice. Furthermore, pre‑treatment with TA suppressed the production of pro‑inflammatory markers, as well as the nuclear translocation of nuclear factor‑κB (NF‑κB) p65 induced by Aβ exposure in BV2 cells. TA also reduced inhibited neurotoxicity and improved neuron survival in a neuron‑microglia co‑culture system^[5]. TA inhibited reactive oxygen species (ROS) generation, induced H2O2 in RVSMCs (rat vascular smooth muscle cells), and inhibited H2O2-induced expression of inducible nitric oxide synthase (iNOS) and NADPH oxidase (NOX) in RVSMCs^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0462 mL
- 10.2312 mL
- 20.4625 mL
- 5 mM
- 0.4092 mL
- 2.0462 mL
- 4.0925 mL
- 10 mM
- 0.2046 mL
- 1.0231 mL
- 2.0462 mL

技术信息

CAS号	13850-16-3	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C30H48O5	运输	蓝冰
分子量	488.70	别名	Tormentic Acid;Tormentolic Acid;Jacarandic acid;2Α,19Α-二羟基熊果酸;委陵菜酸

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Tormentic acid/2Α,19Α-二羟基熊果酸 Catalog No. CSN14489

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