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CAS No.: 40592-88-9

TLR4-IN-C34 Catalog No. CSN22734

Synonyms: TLR4-C34;C34;TLR4-C34-IN

C34 is a TLR4 inhibitor.

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400-920-2911

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实验方案

技术信息

生物活性

描述The innate immune receptor toll-like receptor 4 (TLR4) is a pattern recognition receptor expressed in both hematopoietic and non-hematopoietic cells. C34 is a 2-acetamidopyranoside that inhibits TLR4 in IEC-6 enterocytes and RAW264.7 macrophages in vitro at a dosage of 10μM. Pretreatment with 1mg/kg C34 30 minutes before LPS (3mg/kg) injection significantly reduced luciferase activity in mice. In a mouse model of experimental necrotizing enterocolitis (NEC), oral gavage of C34 (1mg/kg/day) for 4 days attenuated the severity of NEC as demonstrate by marked preservation of the intestinal mucosa, downregulation of pro-inflammatory iNOS expression, and reduced NEC severity score. C34 at 10μM inhibited TLR4 signaling ex vivo in human tissues isolated from infants with NEC^[2].
作用机制C34 is an inhibitor of TLR4 that docks into the hydrophobic internal pocket of the TLR4 co-receptor MD-2^[2].
参考文献

[1] Neal MD, Jia H, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779.
[2] Neal MD, Jia H, Eyer B, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5681 mL
- 12.8403 mL
- 25.6805 mL
- 5 mM
- 0.5136 mL
- 2.5681 mL
- 5.1361 mL
- 10 mM
- 0.2568 mL
- 1.2840 mL
- 2.5681 mL

技术信息

CAS号

40592-88-9

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H27NO9

运输

蓝冰

分子量

389.40

别名

TLR4-C34;C34;TLR4-C34-IN;Toll-Like Receptor 4-C34

溶解度

DMSO	90.0 mg/mL (231.1 mM)
Water	40.0 mg/mL (102.7 mM)

动物实验配方

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