|Tirzepatide肽|CsnPharm

CAS No.: 2023788-19-2

Tirzepatide/Tirzepatide肽 Catalog No. CSN42763

Synonyms: LY3298176

Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors. It was approved for improve blood-sugar control in adults with type 2 diabetes.

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生物活性

描述Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones involved in blood-sugar control. Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood-sugar control. It is a linear polypeptide of 39 amino acids that has been chemically modified by lipidation to improve its uptake into cells and its stability to metabolism. In pharmacokinetic (PK) studies in healthy volunteers for doses ranging from 0.25 to 15 mg peak plasma concentration (Cmax), it was found to be dose proportional ranging between 26 and 874 ng/mL. The maximal concentration (Tmax) for tirzepatide was observed after 1–2 days of administration, and the mean half-life (T1/2) was found to be 116.7 h (i.e., 5 days), thus favoring a weekly dose regimen. It was approved for improve blood-sugar control in adults with type 2 diabetes^[1].
作用机制Tirzepatide is an analogue of gastric inhibitory polypeptide (GIP), but has a greater affinity to GIP receptors than to GLP-1 receptors^[1].
参考文献

[1] Chavda VP, Ajabiya J, Teli D, Bojarska J, Apostolopoulos V. Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review. Molecules. 2022 Jul 5;27(13):4315. doi: 10.3390/molecules27134315. PMID: 35807558; PMCID: PMC9268041.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.2078 mL
- 1.0388 mL
- 2.0775 mL
- 5 mM
- 0.0416 mL
- 0.2078 mL
- 0.4155 mL
- 10 mM
- 0.0208 mL
- 0.1039 mL
- 0.2078 mL

技术信息

CAS号	2023788-19-2	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C225H348N48O68	运输	蓝冰
分子量	4813.45	别名	LY3298176

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