CAS No.: 144494-65-5
Tirofiban/替罗非班 Catalog No. CSN12096
Synonyms: L700462;MK383;替罗非班
Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIb/IIIa receptor used as an antiplatelet drug.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01087723 - - Completed - - NCT01087723 Acute Coronary Syndrome Phase 3 Completed - - NCT01103440 Stable Angina Phase 2 Completed - United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse << - 更多
- 参考文献
- [1] van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.
- [2] Hartman GD, Egbertson MS, et al. Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. J Med Chem. 1992 Nov 27;35(24):4640-2.
- [3] Tirofiban (Aggrastat®)
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 144494-65-5 | 储存条件 |
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| 分子式 | C22H36N2O5S | 运输 | 蓝冰 | |
| 分子量 | 440.60 | 别名 | L700462;MK383;替罗非班 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01087723 | - | - | Completed | - | - |
| NCT01087723 | Acute Coronary Syndrome | Phase 3 | Completed | - | - |
| NCT01103440 | Stable Angina | Phase 2 | Completed | - | United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse << |
| NCT03691675 | Drug-coated Balloon | Not Applicable | Not yet recruiting | April 2019 | - |
| NCT01863134 | Non ST Elevation Myocardial In... more >>farction Collapse << | Phase 4 | Completed | - | United States, New York ... more >> Albert Einstein College of Medicine New York, New York, United States Poland First Department of Cardiac Surgery, Medical University of Silesia Katowice, Slaskie, Poland, 40-635 Center for Cardiovascular Research and Development, American Heart of Poland Katowice, Poland Department of Internal Medicine and Clinical Pharmacology Katowice, Poland First Department of Cardiology, Medical University of Silesia Katowice, Poland Division of Molecular Biology and Clinical Genetics, Jagiellonian University Medical College Krakow, Poland Collapse << |
| NCT01717573 | ST-Elevation Myocardial Infarc... more >>tion Collapse << | Not Applicable | Completed | - | United Kingdom ... more >> Golden Jubilee National Hospital Clydebank, Glasgow, United Kingdom, G81 4DY Collapse << |
| NCT03146858 | Primary Percutaneous Coronary ... more >>Intervention Collapse << | Phase 4 | Completed | - | United Kingdom ... more >> Sheffield Teaching Hospitals NHS Foundation Trust Sheffield, South Yorkshire, United Kingdom, S5 7AU Collapse << |
| NCT01863134 | - | - | Completed | - | - |
| NCT01598337 | Coronary Artery Disease | Phase 3 | Unknown | - | Saudi Arabia ... more >> Prince Sultan Cardiac Center Recruiting Riyadh, Saudi Arabia Contact: Hussein S Alamri, MD amriheart@hotmail.com Principal Investigator: Antonio Calafiore Principal Investigator: Hussein S Alamri, MD Principal Investigator: Abdulrahman M almoghairi, MD Collapse << |
| NCT01103440 | - | - | Completed | - | - |
| NCT02592720 | Acute Coronary Syndromes | Phase 4 | Unknown | October 2017 | China, Shaanxi ... more >> Xijing hospital Recruiting Xi'an, Shaanxi, China, 710032 Contact: Dongdong Sun, M.D.,Ph.D 86 18691569930 wintersun3@gmail.com Collapse << |
| NCT01433627 | Acute Coronary Syndromes ... more >> STEMI NSTEMI Collapse << | Phase 3 | Unknown | December 2015 | - |
| NCT03078257 | Coronary Artery Disease | Phase 1 | Recruiting | December 2017 | China, Jiangsu ... more >> First Affiliated Hospital of Nanjing Medical University Recruiting Nanjing, Jiangsu, China, 210029 Contact: Fuming Zhang, M.D. +86-25-83718836 ext 6360 jsphkj@163.com Contact: Yi Chai, M.D. +86-25-83718836 ext 6360 jsphkj@163.com Sub-Investigator: Dingguo Zhang, Ph.D Collapse << |
| NCT00713557 | - | - | Terminated(devices applied in ... more >>the study were no more available in the market, and medical intervention section was completed.) Collapse << | - | China, Shanghai ... more >> Dept. of Cardiology, Ruijin Hospital Shanghai, Shanghai, China, 200025 Collapse << |
| NCT00251576 | Acute Coronary Syndrome | Phase 3 | Completed | - | - |
| NCT00445263 | CORONARY DISEASE | Phase 4 | Terminated(Because of inclusio... more >>n delay) Collapse << | - | France ... more >> Samu 93 - Chu Avicenne Bobigny, Ile de France, France, 93000 Collapse << |
| NCT03406819 | ST Segment Elevation Myocardia... more >>l Infarction Primary Percutaneous Coronary Intervention Collapse << | Not Applicable | Recruiting | December 31, 2019 | China, Henan ... more >> Anyang District Hospital Recruiting Anyang, Henan, China, 455000 The 99th Central Hospital of the People's Liberation Army Recruiting Jiaozuo, Henan, China, 454000 The People's Hospital of Jiaozuo Recruiting Jiaozuo, Henan, China, 454002 The second people's Hospital of Jiyuan Recruiting Jiyuan, Henan, China, 454000 Huaihe Hospital of Henan University Recruiting Kaifeng, Henan, China, 475000 Kaifeng Central Hospital Recruiting Kaifeng, Henan, China, 475000 The First Affiliated Hospital of Henan University of Science and Technology Recruiting Luoyang, Henan, China, 471003 Lushan People's Hospital Recruiting Lushan, Henan, China, 467300 Nanyang City Center Hospital Recruiting Nanyang, Henan, China, 473000 Pingmei Shenma Medical Group General Hospital Recruiting Pingdingshan, Henan, China, 467000 The Second People's Hospital of Pingdingshan Recruiting Pingdingshan, Henan, China, 467000 Puyang Oilfield General Hospital Recruiting Puyang, Henan, China, 457000 Puyang People's Hospital Recruiting Puyang, Henan, China, 457099 Yellow River Sanmenxia hospital Recruiting Sanmenxia, Henan, China, 472000 The First People's Hospital of Shangqiu Recruiting Shangqiu, Henan, China, 476000 The First Affiliated Hospital of Xinxiang Medical University Recruiting Xinxiang, Henan, China, 453100 Xinyang Central Hospital Recruiting Xinyang, Henan, China, 464000 Yanshi People's Hospital Recruiting Yanshi, Henan, China, 471900 Zhengzhou First People's Hospital Recruiting Zhengzhou, Henan, China, 450004 Zhengzhou Cardiovascular Hospital Recruiting Zhengzhou, Henan, China, 450006 Zhengzhou Central Hospital Recruiting Zhengzhou, Henan, China, 450007 The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Chunguang Qiu, Phd People's Hospital of Zhengzhou Recruiting Zhengzhou, Henan, China, 450053 The First People's Hospital of Xinmi Recruiting Zhengzhou, Henan, China, 452370 Zhoukou Central Hospital Recruiting Zhoukou, Henan, China, 466000 The First People's Hospital of Zhumadian Recruiting Zhumadian, Henan, China, 463000 Zhumadian Central Hospital Recruiting Zhumadian, Henan, China, 463000 China, Shanxi Jincheng People's Hospital Recruiting Jincheng, Shanxi, China, 048026 Collapse << |
| NCT00653601 | - | - | Unknown | April 2011 | United States, California ... more >> Cedars-Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Sanjay Kaul, MD 310-423-4876 sanjay.kaul@cshs.org Contact: Suhail Dohad, MD 310-278-3400 dohad@cvmg.com Principal Investigator: Sanjay Kaul, MD Sub-Investigator: Amanda B Lamer, PharmD Sub-Investigator: Hai Tran, PharmD Sub-Investigator: Stanley Chou, MD Sub-Investigator: Suhail Dohad, MD Collapse << |
| NCT03406832 | ST Segment Elevation Myocardia... more >>l Infarction Elective Percutaneous Coronary Intervention Collapse << | Not Applicable | Recruiting | December 31, 2019 | China, Henan ... more >> Anyang District Hospital Recruiting Anyang, Henan, China, 455000 The 99th Central Hospital of the People's Liberation Army Recruiting Jiaozuo, Henan, China, 454000 The People's Hospital of Jiaozuo Recruiting Jiaozuo, Henan, China, 454002 The second people's Hospital of Jiyuan Recruiting Jiyuan, Henan, China, 454000 Huaihe Hospital of Henan University Recruiting Kaifeng, Henan, China, 475000 Kaifeng Central Hospital Recruiting Kaifeng, Henan, China, 475000 The First Affiliated Hospital of Henan University of Science and Technology Recruiting Luoyang, Henan, China, 471003 Lushan People's Hospital Recruiting Lushan, Henan, China, 467300 Nanyang City Center Hospital Recruiting Nanyang, Henan, China, 473000 Pingmei Shenma Medical Group General Hospital Recruiting Pingdingshan, Henan, China, 467000 The Second People's Hospital of Pingdingshan Recruiting Pingdingshan, Henan, China, 467000 Puyang Oilfield General Hospital Recruiting Puyang, Henan, China, 457000 Puyang People's Hospital Recruiting Puyang, Henan, China, 457099 Yellow River Sanmenxia hospital Recruiting Sanmenxia, Henan, China, 472000 The First People's Hospital of Shangqiu Recruiting Shangqiu, Henan, China, 476000 The First Affiliated Hospital of Xinxiang Medical University Recruiting Xinxiang, Henan, China, 453100 Xinyang Central Hospital Recruiting Xinyang, Henan, China, 464000 Yanshi People's Hospital Recruiting Yanshi, Henan, China, 471900 Zhengzhou First People's Hospital Recruiting Zhengzhou, Henan, China, 450004 Zhengzhou Cardiovascular Hospital Recruiting Zhengzhou, Henan, China, 450006 Zhengzhou Central Hospital Recruiting Zhengzhou, Henan, China, 450007 The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Chunguang Qiu, Phd People's Hospital of Zhengzhou Recruiting Zhengzhou, Henan, China, 450053 The First People's Hospital of Xinmi Recruiting Zhengzhou, Henan, China, 452370 Zhoukou Central Hospital Recruiting Zhoukou, Henan, China, 466000 The First People's Hospital of Zhumadian Recruiting Zhumadian, Henan, China, 463000 Zhumadian Central Hospital Recruiting Zhumadian, Henan, China, 463000 China, Shanxi Jincheng People's Hospital Recruiting Jincheng, Shanxi, China, 048026 Collapse << |
| NCT01696110 | Acute Myocardial Infarction ... more >> Percutaneous Coronary Intervention Collapse << | Phase 4 | Completed | - | - |
| NCT00300833 | Acute Myocardial Infarction | Phase 4 | Unknown | - | Israel ... more >> Cardiovascular Division, The Baruch Padeh Medical Center, Poriya, Recruiting Tiberias, Israel, 15208 Magen David , Recruiting Tiberias, Israel Contact: Sergay Krablikov, Dr Collapse << |
| NCT03691727 | Subarachnoid Hemorrhage, Aneur... more >>ysmal Collapse << | Phase 1 Phase 2 | Not yet recruiting | November 2022 | - |
| NCT00611169 | Acute Myocardial Infarction | Phase 4 | Completed | - | - |
| NCT00445263 | - | - | Terminated(Because of inclusio... more >>n delay) Collapse << | - | - |
| NCT00229515 | Myocardial Infarction | Phase 4 | Unknown | March 2012 | Italy ... more >> Cattedra di Cardiologia, Azienda Ospedaliera Universitaria di Ferrara Ferrara, Italy, 44100 Collapse << |
| NCT00538317 | Acute Myocardial Infarction | Phase 4 | Completed | - | France ... more >> Hospices Civils de Lyon Lyon, France, 6900 Collapse << |
| NCT00306228 | Myocardial Infarction | Phase 4 | Completed | - | Spain ... more >> Instituto de Ciencias del Corazón (ICICOR). Hospital Clínico Universitario de Valladolid Valladolid, Spain, 47005 Collapse << |
| NCT00790387 | Acute Coronary Syndrome | Phase 4 | Completed | - | Australia, Queensland ... more >> The Prince Charles Hospital Brisbane, Queensland, Australia, 4032 Collapse << |
| NCT02131220 | Myocardial Infarction ... more >> Percutaneous Coronary Intervention Thrombolytic Therapy Collapse << | Phase 4 | Completed | - | China, Shanghai ... more >> Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai, Shanghai, China, 200032 Collapse << |
| NCT01336348 | ST Segment Elevation Myocardia... more >>l Infarction Collapse << | Phase 3 | Completed | - | Italy ... more >> Cardiology Unit Ferrara, Italy, 44100 Collapse << |
| NCT01660373 | Non-ST Segment Elevation Acute... more >> Coronary Syndrome Collapse << | Phase 3 | Unknown | August 2013 | Korea, Republic of ... more >> Pusan National University Yangsan Hospital Recruiting Yangsan, Kyeongsangnamdo, Korea, Republic of, 626-770 Contact: June Hong Kim, MD, PhD +82-10-8231-7171 junehongk@gmail.com Contact: Dongcheul Han, MD +82-10-2992-6270 usdoc12@gmail.com Principal Investigator: June Hong Kim, MD,PhD Sub-Investigator: Dongcheul Han, MD Collapse << |
| NCT00383136 | Acute Myocardial Infarction | Phase 4 | Completed | - | Italy ... more >> Divisione Di Cardiologia, Ospedale Maggiore Bologna, BO, Italy, 40100 Laboratorio Di Emodinamica, Istituto Di Cardiologia, Azienda Ospedaliera S.Orsola Malpighi Bologna, BO, Italy, 40138 Azienda Ospedaliera Universitaria Policlinico Modena, MO, Italy, 41100 Divisione Di Cardiologia, Ospedale S.Maria Nuova Reggio Emilia, RE, Italy, 42100 Divisione Di Cardiologia, Ospedale Per Gli Infermi Rimini, RN, Italy, 47900 Divisione Di Cardiologia Ii, Ospedale Policlinico Le Molinette Torino, TO, Italy, 10100 Collapse << |
| NCT00398463 | Angioplasty, Transluminal, Per... more >>cutaneous Coronary Collapse << | Phase 4 | Completed | - | Italy ... more >> Cattedra di Cardiologia, Azienda Ospedaliera Universitaria di Ferrara Ferrara, Fe, Italy, 44100 Collapse << |
| NCT01522417 | Myocardial Infarction ... more >> Acute Coronary Syndromes Unstable Angina Collapse << | Phase 2 | Recruiting | July 2019 | United States, Florida ... more >> Osceola Regional Medical Center Completed Kissimmee, Florida, United States, 34741 Northside Hospital Completed Saint Petersburg, Florida, United States, 33709 United States, Georgia Emory University Hospital Midtown Completed Atlanta, Georgia, United States, 30308 Emory University Hospital Completed Atlanta, Georgia, United States, 30322 North Georgia Heart Center Completed Gainesville, Georgia, United States, 30501 Redmond Regional Medical Center Recruiting Rome, Georgia, United States, 30165 Principal Investigator: Hector R Picon, MD Archbold Medical Center Completed Thomasville, Georgia, United States, 31792 United States, New York Lenox Hill Hospital Completed New York, New York, United States, 10075 United States, Oklahoma University of Oklahoma Health Sciences Center Recruiting Oklahoma City, Oklahoma, United States, 73104 Principal Investigator: Mazen Abu-Fadel, MD United States, Pennsylvania Doylestown Hospital Completed Doylestown, Pennsylvania, United States, 18901 Penn Presbyterian Medical Center Completed Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Centennial Heart Recruiting Nashville, Tennessee, United States, 37203 Principal Investigator: Brian K Jefferson, MD United States, Virginia Chippenham Hospital Recruiting Richmond, Virginia, United States, 23225 Principal Investigator: Michael L Arcarese, MD Collapse << |
| NCT01498003 | Coronary Artery Disease | Phase 4 | Completed | - | China, Shanghai ... more >> Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai, Shanghai, China, 200025 Collapse << |
| NCT01245725 | Myocardial Infarction ... more >> Acute Coronary Syndromes Unstable Angina Percutaneous Coronary Intervention Collapse << | Phase 3 | Withdrawn(Study was not initia... more >>ted, change in clinical development) Collapse << | - | - |
| NCT02978040 | Coronary Artery Disease ... more >> STEMI - ST Elevation Myocardial Infarction Collapse << | Phase 4 | Recruiting | April 2019 | France ... more >> Group Hospitalier Pitié-Salpetrière Not yet recruiting Paris, France, 75013 Contact: Jean-Philippe Collet, Prof jean-philippe.collet@aphp.fr Italy University of Ferrara Not yet recruiting Ferrara, Italy, 44124 Contact: Gianluca Campo, Prof cmpglc@unife.it University of Naples Federico II Recruiting Naples, Italy, 80131 Contact: Giovanni Esposito, Prof espogiov@unina.it University of Sassari Not yet recruiting Sassari, Italy, 07100 Contact: Guido Parodi, Prof parodiguido@gmail.com Principal Investigator: Pierfranco Terrosu, MD Switzerland Bern University Hospital Recruiting Bern, Switzerland, 3010 Contact: Marco Valgimigli, Prof +41 316329653 marco.valgimigli@insel.ch Contact: Giuseppe Gargiulo, MD +41 316327205 giuseppe.gargiulo@insel.ch Collapse << |
| NCT00566891 | Coronary Artery Disease | Phase 4 | Completed | - | Italy ... more >> S Anna Hospital Catanzaro, Italy, 88100 Collapse << |
| NCT00407771 | Coronary Artery Disease | Phase 4 | Unknown | December 2008 | Jordan ... more >> Jordan Hospital Not yet recruiting Amman, Jordan, 11152 Principal Investigator: Imad A Alhaddad, MD Collapse << |
| NCT03357133 | Ischemic Stroke | Phase 2 Phase 3 | Recruiting | March 31, 2019 | China, An Hui ... more >> Suzhou Municipal Hoapital Recruiting Suzhou, An Hui, China Contact: Zhengfei Ma, MD China, Beijing Xuanwu Hospital, Capital Medical University Recruiting Beijing, Beijing, China, 100053 Contact: Xunming Ji Principal Investigator: Xunming Ji China, Henan The Central Hospital of Luohe City Recruiting Luohe, Henan, China Contact: Shengming Huang, MD hsm912@126.com China, Sichuan Luzhou People's Hospital Recruiting Luzhou, Sichuan, China Contact: Li Zhou, MD China Xiangtan Central Hospital Recruiting Xiangtan, China Contact: Yong Liang The Fifth Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, China Contact: Lijun Wang The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, China Contact: Yajun Lian Collapse << |
| NCT01181388 | Myocardial Infarction | Not Applicable | Unknown | October 2012 | China, Beijing ... more >> the 28th division, Beijing Anzhen Hospital Recruiting Beijing, Beijing, China, 100029 Contact: Shaoping Shaoping, MD. PhD +861064456995 wang_shaoping@hotmail.com Contact: Yunpeng Chi, MD +861064456541 chiyunpeng0711@sohu.com Collapse << |
| NCT01109134 | Acute Myocardial Infarction | Phase 3 | Completed | - | - |
| NCT03048019 | - | - | Recruiting | May 29, 2019 | United States, Virginia ... more >> Inova Health Care System Recruiting Falls Church, Virginia, United States, 22042 Contact: Kevin Bliden, BS, MBA 703-776-7702 kevin.bliden@inova.org Collapse << |
| NCT03114995 | - | - | Completed | - | - |
| NCT02592694 | ST-elevation Myocardial Infarc... more >>tion Collapse << | Phase 4 | Unknown | October 2017 | China, Shaanxi ... more >> Xijing hospital Recruiting Xi'an, Shaanxi, China, 710032 Contact: Dongdong Sun, M.D.,Ph.D 86 18691569930 wintersun3@gmail.com Collapse << |
| NCT01766154 | Renal Insufficiency | Phase 1 | Completed | - | United States, Florida ... more >> Avail Clinical Research, LLC DeLand, Florida, United States, 32720 Collapse << |
| NCT02054000 | No-Reflow Phenomenon | Phase 4 | Completed | - | Turkey ... more >> Erciyes University School of Medicine Kayseri, Turkey, 38039 Collapse << |
| NCT03114995 | Non-ST Elevation Myocardial In... more >>farction Collapse << | Phase 4 | Completed | - | - |
| NCT02294994 | Coronary Artery Disease | Phase 4 | Unknown | December 2016 | China, Jilin ... more >> The sencond hospital of Jilin University Recruiting Changchun, Jilin, China, 130041 Contact: Liu Bin, M.D. +86 13500810268 liubin3333@vip.sina.com Collapse << |
| 靶点 | Description | IC50 |
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