生物活性

• 描述Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02848443	Metastatic Colorectal Cancer	Phase 1	Recruiting	December 2019	Austria ... more >> Allgemeines Krankenhaus - Universitätskliniken Klinische Abteilung für Onkologie Recruiting Wien, Austria France CHU Timone Recruiting Marseille, France Hôpital Saint Antoine Recruiting Paris, France Hôpital Universitaire Pitié Salpêtrière - Pavillon Antonin Gosset Recruiting Paris, France Centre Eugène Marquis Recruiting Rennes, France HIA Bégin Recruiting Saint Mandé, France Gustave Roussy Recruiting Villejuif, France Germany St. Josef-Hospital, Klinikum der Ruhr-Universität Bochum Abteilung für Hämatologie und Onkologie Recruiting Bochum, Germany Universitaetsklinikum Hamburg-Eppendorf Hubertus Wald Tumorzentrum - UCCH Recruiting Hamburg, Germany Klinikum der Universität München Campus Großhadern, Medizinische Klinik und Poliklinik III Recruiting Munchen, Germany Universitätsklinikum Ulm, Zentrum für Innere Medizin, Klinik für Innere Medizin I Recruiting Ulm, Germany Klinikum Wolfsburg, Medizinische Klinik II Recruiting Wolfsburg, Germany Hungary Magyar Honvedseg Egeszsegugyi Kozpont Onkologiai Osztaly Recruiting Budapest, Hungary Orszagos Onkologiai Intezet "B" Belgyogyaszati-Onkologiai O. Es Klin. Farmakologiai O. Recruiting Budapest, Hungary Semmelweis Egyetem, I. sz. Belgyogyaszati Klinika - Klin. Farmakologiai Reszleg Recruiting Budapest, Hungary Italy ARNAS - Azienda Ospedaliera Garibaldi - Nesima Struttura Complessa di Oncologia Medica Recruiting Catania, Italy Ist.Scientifico Romagnolo per lo Studio e la Cura dei Tumori Department of Clinical Oncology Recruiting Meldola, Italy Poiclinico G.B. Rossi A.O.U.I. di Verona Recruiting Verona, Italy Spain ICO Badalona. H. Germans Trials y Pujol, Servicio de Oncología médica Recruiting Badalona, Spain Hospital Vall D'Hebron (VHIO) Recruiting Barcelona, Spain HOSPITAL UNIVERSITARIO GREGORIO MARAÑON Oncología Médica Recruiting Madrid, Spain Hospital Universitario Madrid Sanchinarro Recruiting Madrid, Spain Hospital Universitario Ramón y Cajal de Madrid Recruiting Madrid, Spain Hospital Clinico de Valencia Recruiting Valencia, Spain United Kingdom Christie Hospital NHS Foundation Trust GI & Endocrine Recruiting Manchester, United Kingdom Collapse <<
  NCT03190616	Colorectal Neoplasms	Phase 2	Recruiting	December 30, 2019	China, Jiangsu ... more >> the second hospital of Changzhou city Not yet recruiting Changzhou, Jiangsu, China, 213000 Contact: Hua Jiang, Dr.    008651981099988       Nanjing 81 Hospital Not yet recruiting Nanjing, Jiangsu, China, 210000 Contact: Yingxia Chen, Dr.          the first affiliated hospital with Nanjing Medical University Recruiting Nanjing, Jiangsu, China, 210029 Contact: xiaofeng chen, Dr.          Principal Investigator: Yanhong Gu, Dr          Jiangnan University affiliated hospital Not yet recruiting Wuxi, Jiangsu, China, 214000 Contact: Dong Hua, Dr.    008651088683114 Collapse <<
  NCT03317119	RAS Family Gene Mutation ... more >> Stage III Colon Cancer AJCC v7 Stage III Colorectal Cancer AJCC v7 Stage III Rectal Cancer AJCC v7 Stage IIIA Colon Cancer AJCC v7 Stage IIIA Colorectal Cancer AJCC v7 Stage IIIA Rectal Cancer AJCC v7 Stage IIIB Colon Cancer AJCC v7 Stage IIIB Colorectal Cancer AJCC v7 Stage IIIB Rectal Cancer AJCC v7 Stage IIIC Colon Cancer AJCC v7 Stage IIIC Colorectal Cancer AJCC v7 Stage IIIC Rectal Cancer AJCC v7 Stage IV Colon Cancer AJCC v7 Stage IV Colorectal Cancer AJCC v7 Stage IV Rectal Cancer AJCC v7 Stage IVA Colon Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVA Rectal Cancer AJCC v7 Stage IVB Colon Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Stage IVB Rectal Cancer AJCC v7 Collapse <<	Phase 1	Recruiting	December 2019	United States, California ... more >> City of Hope Corona Recruiting Corona, California, United States, 92879 Contact: Cheryl Corpus    626-256-4673 ext 81529       Principal Investigator: Misagh Karimi, MD          City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Marwan Fakih, MD    626-256-4673    mfakih@coh.org    Principal Investigator: Marwan Fakih, MD          City of Hope Antelope Valley Recruiting Lancaster, California, United States, 93534 Contact: Regan Johnson    626-256-4673 ext 25648       Principal Investigator: Mohammad Fekrazad, MD          City of Hope Mission Hills Recruiting Mission Hills, California, United States, 91345 Contact: Amy Shousha    626-256-4673 ext 81865       Principal Investigator: Suzy Melkonian, MD          City of Hope Rancho Cucamonga Recruiting Rancho Cucamonga, California, United States, 91730 Contact: Valerie Estala    626-256-4673 ext 81699       Principal Investigator: Behnam Ebrahimi, MD          City of Hope South Pasadena Recruiting South Pasadena, California, United States, 91030 Contact: Odessa Rodriguez    626-256-4673 ext 81409       Principal Investigator: Christina Yeon, MD          City of Hope West Covina Recruiting West Covina, California, United States, 91790 Contact: Meizi Zheng    626-256-4673 ext 81336       Principal Investigator: Gargi Upadhyaya, MD Collapse <<

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• 参考文献

• [1] Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100.

  [2] Lee SJ, Yeo JS, et al. Thymidine phosphorylase influences [(18)F] fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35.