CAS No.: 87-11-6
Thiolutin Catalog No. CSN20001
Synonyms: Acetopyrrothin
Thiolutin is an antibiotic which inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Thiolutin also suppresses tumor cell-induced angiogenesis.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Lauinger L, Li J, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 May 1.
- [2] Huang S, Tong MH, et al. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137. Anticancer Agents Med Chem. 2015;15(3):277-84.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 87-11-6 | 储存条件 |
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| 分子式 | C8H8N2O2S2 | 运输 | 蓝冰 | |
| 分子量 | 228.29 | 别名 | Acetopyrrothin |
