|N-(2,6-二溴-4-(三氟甲氧基)苯基)-2-甲基-4-(三氟甲基)噻唑-5-甲酰胺|CsnPharm

CAS No.: 130000-40-7

Thifluzamide/噻呋酰胺 Catalog No. CSN12438

Synonyms: 噻呋酰胺

Thifluzamide is an aromatic amide fungicide against rice fungal diseases.

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技术信息

生物活性

描述Thifluzamide, a succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in rice fields throughout the world and causes hepatotoxicity in zebrafish (Danio reio) Yang Y, Dong F, Liu X, Xu J, Wu X, Qi S, Liu W, Zheng Y. Thifluzamide affects lipid metabolism in zebrafish (Danio reio). Sci Total Environ. 2018 Aug 15;633:1227-1236|https://pubmed.ncbi.nlm.nih.gov/29758875|https://pubmed.ncbi.nlm.nih.gov/29758875. Thifluzamide repressed glucagon (GC) levels but increased growth hormone (GH) levels, and changed the expression of the genes related to growth and development. Additionally, protein kinase A (PKA) and leptin levels were obviously decreased in zebrafish after exposure to thifluzamide for 28 days, but the phosphorylation of cAMP responsive element-binding protein (CREB) was increased^[3]. Zebrafish embryos were treated with thifluzamide (0, 0.19, 1.90 and 2.85 mg/L) for 4 days. Exposure to thifluzamide induced pronounced changes in embryo brain and melatonin levels. In addition, the expression levels of genes related to development, behavior and reproduction were significantly changed by thifluzamide^[4]. Reactive oxygen species (ROS) increased across all thifluzamide treatments, and the activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST) tended to be inhibited by thifluzamide. Thifluzamide presents a potential risk to earthworms at the concentration of 10.0 mg/kg, and its use should be moderated to reduce damage to soil ecosystem function^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8937 mL
- 9.4686 mL
- 18.9372 mL
- 5 mM
- 0.3787 mL
- 1.8937 mL
- 3.7874 mL
- 10 mM
- 0.1894 mL
- 0.9469 mL
- 1.8937 mL

技术信息

CAS号

130000-40-7

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H6Br2F6N2O2S

运输

蓝冰

分子量

528.06

别名

噻呋酰胺

溶解度

DMSO	28.0 mg/mL (53.0 mM)

动物实验配方

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