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CAS No.: 4670-05-7

Theaflavin/茶黄素 Catalog No. CSN12074

Synonyms: 茶黄素

Theaflavin, a type of thearubigins, exhibits inhibition of xanthine oxidase enzyme and can scavenge various oxidation radicals with anti-oxidant and anti-tumor activities. It can be purified from the leaves of Camellia sinensis (L.) O. Kuntze.

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技术信息

生物活性

描述Theaflavin (TF) is a suitable natural inhibitor against influenza A (H1N1) neuraminidase. Theaflavin, found in green tea, is observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Theaflavin is a plant product traditionally used for treatment of influenza infection. Theaflavin derivatives have shown pronounced antiviral activity^[3]. Theaflavin was strong inhibitors of OATP (Organic anion-transporting polypeptide) 2B1-mediated E3S uptake. Theaflavin showed a significantly higher uptake into the OATP2B1-expressing HEK293 cells than the control cells. The concentration dependence of the uptake of theaflavin was determined over a range of concentrations (0.5-100 μM) and the kinetic parameters (Km and Vmax) of theaflavin uptake were found to be 5.12 ± 0.67 μM and 41.6 ± 1.3 pmol/mg protein/min, respectively^[4]. TF improved survival of irradiated wild-type mice and ameliorated TBI-induced (total body irradiation) hematopoietic injury by attenuating myelosuppression and myeloid skewing, increasing HSC (hematopoietic stem cell) frequency, and promoting reconstitution of irradiated HSCs. Furthermore, TF inhibited TBI-induced HSC senescence^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03194620	Healthy	Not Applicable	Completed	-	United States, California ... more >> UC Davis Davis, California, United States, 95616 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7715 mL
- 8.8575 mL
- 17.7150 mL
- 5 mM
- 0.3543 mL
- 1.7715 mL
- 3.5430 mL
- 10 mM
- 0.1771 mL
- 0.8857 mL
- 1.7715 mL

技术信息

CAS号

4670-05-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H24O12

运输

蓝冰

分子量

564.49

别名

茶黄素

溶解度

DMSO	120.0 mg/mL (212.6 mM) warming
Water	2.0 mg/mL (3.5 mM) warming

动物实验配方

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