CAS No.: 1197300-24-5
TGR5 Receptor Agonist/TGR5受体激动剂 Catalog No. CSN13717
Synonyms: CCDC;MDK-00245
TGR5 receptor agonist, a potent TGR5 (GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01674946 Echolocation Phase 1 Completed - Switzerland ... more >> University Hospital Basel, Phase 1 Research Unit Basel, Switzerland, 4031 Collapse << - 参考文献
- [1] Lo SH, Cheng KC, et al. Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay. Drug Des Devel Ther. 2016 Aug 22;10:2669-76.
- [2] Baghdasaryan A, Claudel T, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output. Hepatology. 2011 Oct;54(4):1303-12.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1197300-24-5 | 储存条件 |
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| 分子式 | C18H14Cl2N2O2 | 运输 | 蓝冰 | |||
| 分子量 | 361.22 | 别名 | CCDC;MDK-00245 | |||
| 溶解度 |
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动物实验配方 |
