|6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑盐酸盐|CsnPharm

CAS No.: 5086-74-8

Tetramisole HCl/盐酸四咪唑 Catalog No. CSN13486

Synonyms: (±)-Tetramisole hydrochloride;DL-Tetramisole hydrochloride;R-829

Tetramisole HCl is an inhibitor of alkaline phosphatases, is used to treat parasitic worm infections.

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400-920-2911

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技术信息

生物活性

描述Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. Tetramisole, a well documented TNAP (tissue non-specific alkaline phosphatase) inhibitor, to block TNAP activity. Tetramisole reduced neuronal response amplitude in a dose-dependent manner. Tetramisole also decreased axonal conduction velocity. The decrease of axonal conduction velocity and preliminary intracellular data suggest that tetramisole blocks voltage-dependent sodium channels^[3]. Nervous involvement in the acute toxicity of tetramisole. Subcutaneous injection of tetramisole at 0.5 and 1mg/kg did not significantly affect general locomotor activity of the mice in 5-min open-field activity test or negative geotaxis performance and landing foot splay. However, the 1 mg/kg dose of tetramisole significantly increased the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Repeated tetramisole treatments (0.5 and 1 mg/kg) also significantly decreased the time needed to complete the negative geotaxis task and reduced landing foot splay^[4].
参考文献

[1] Aceves J, Erlij D, Martinez-Maranon R. The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br J Pharmacol. 1970 May;38(3):602-7.
[2] Raeymaekers AH, Allewijn FT, et al. Novel broad-spectrum anthelmintics. Tetramisole and related derivatives of 6-arylimidazo[2,1-b] thiazole. J Med Chem. 1966 Jul;9(4):545-51.
[3] Nowak LG, Rosay B, Czégé D, Fonta C. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex. Subcell Biochem. 2015;76:239‐281
[4] Mohammad FK, Faris GA, Rhayma MS, Ahmed K. Neurobehavioral effects of tetramisole in mice. Neurotoxicology. 2006;27(2):153‐157

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1536 mL
- 20.7682 mL
- 41.5365 mL
- 5 mM
- 0.8307 mL
- 4.1536 mL
- 8.3073 mL
- 10 mM
- 0.4154 mL
- 2.0768 mL
- 4.1536 mL

技术信息

CAS号

5086-74-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H13ClN2S

运输

蓝冰

分子量

240.75

别名

(±)-Tetramisole hydrochloride;DL-Tetramisole hydrochloride;R-829;(±)-Tetramisole HCl;DL-Tetramisole HCl;R-8299;Tetramisole Hydrochloride;盐酸四咪唑

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

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Tetramisole HCl/盐酸四咪唑 Catalog No. CSN13486

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