生物活性

• 描述Temocillin, a 6-α-methoxy derivative of ticarcillin, is a β-lactamase-resistant penicillin used primarily for the treatment of multiple drug-resistant, Gram-negative bacteria.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03440216	Pharmacokinetics ... more >> Anti-Bacterial Agents Infection, Bacterial Infections, Respiratory Infection Drug Monitoring Collapse <<	Not Applicable	Recruiting	October 15, 2020	Belgium ... more >> Cliniques universitaires Saint-Luc Recruiting Brussels, Belgium, 1200 Contact: Pierre F. Laterre, MD       pierre-francois.laterre@uclouvain.be Collapse <<
  NCT03543436	Urinary Tract Infections	Phase 3	Not yet recruiting	July 2020	France ... more >> CHU de Martinique Not yet recruiting Fort-de-france, Martinique, France Principal Investigator: André CABIE, MD, PhD          CHU de Grenoble Hospital Grenoble, France CHRU de Lille Not yet recruiting Lille, France, 59000 Principal Investigator: Fanny VUOTTO, MD          APHP - Cochin Hospital Paris, France, 75014 APHP - Necker-Enfants maladies Hospital Not yet recruiting Paris, France, 75015 Principal Investigator: Olivier LORTHOLARY, MD, PhD          Sub-Investigator: Benoit PILMIS, MD          APHP - Beaujon Hospital Paris, France APHP - Georges Pompidou European Hospital Not yet recruiting Paris, France Principal Investigator: David LEBEAUX, MD, PhD          APHP - Saint-Antoine Hospital Not yet recruiting Paris, France Principal Investigator: Laure SURGERS, Md, PhD          Saint-Joseph Hospital Not yet recruiting Paris, France Principal Investigator: Benoit PILMIS, MD          CHU de Pau Not yet recruiting Pau, France Principal Investigator: Valérie GABORIEAU, MD          CHU de Poitiers Not yet recruiting Poitiers, France Principal Investigator: Blandine RAMMAERT, MD, PhD Collapse <<
  NCT02959957	Urinary Tract Infections	Phase 4	Recruiting	June 2019	Sweden ... more >> Danderyd University Hospital Recruiting Danderyd, Stockholm, Sweden, 182 88 Contact: Jesper Ericsson       jesper.ericsson@ds.se    Karolinska University Hospital Recruiting Solna, Stockholm, Sweden, 171 76 Contact: Anders Ternhag       anders.ternhag@karolinska.se    Sahlgrenska University Hospital Recruiting Göteborg, Sweden, 416 50 Contact: Daniel Bremell       daniel.bremell@infect.gu.se    Helsingborg Hospital Recruiting Helsingborg, Sweden, 251 87 Contact: Anna-Karin Lindgren       Anna-Karin.A.Lindgren@skane.se    Linköping University Hospital Recruiting Linköping, Sweden, 581 85 Contact: Åse Östholm Balkhed       ase.ostholm.balkhed@lio.se    Skåne University Hospital Recruiting Lund, Sweden, 221 85 Contact: Gisela Otto       gisela.otto@skane.se    Capio S:t Görans hospital Recruiting Stockholm, Sweden, 112 81 Contact: Daniel Holmström       daniel.holmstrom@capiostgoran.se    Sundsvall Hospital Recruiting Sundsvall, Sweden, 856 43 Contact: Maria Tempé       maria.tempe@lvn.se    University Hospital of Umeå Recruiting Umeå, Sweden, 901 85 Contact: Maria Furberg       maria.furberg@umu.se    Örebro University Hospital Recruiting Örebro, Sweden, 701 85 Contact: Simon Athlin       simon.athlin@regionorebrolan.se    Östersund Hospital Recruiting Östersund, Sweden, 83131 Contact: Elin Hedman       elin.hedman@regionjh.se Collapse <<

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• 参考文献

• [1] Alexandre K, Chau F, et al. Activity of temocillin in a lethal murine model of infection of intra-abdominal origin due to KPC-producing Escherichia coli. J Antimicrob Chemother. 2016 Jul;71(7):1899-904.

  [2] Cuvelier B, Eloy P, et al. Minimal amounts of dipalmitoylphosphatidylcholine improve aerosol performance of spray-dried temocillin powders for inhalation. Int J Pharm. 2015 Nov 30;495(2):981-90.