|2-((5-甲氧基-1H-吲哚-3-基)亚甲基)-N-戊基肼-1-甲脒马来酸盐|CsnPharm

CAS No.: 189188-57-6

Tegaserod maleate/马来酸替加色罗 Catalog No. CSN16726

Synonyms: SDZ-HTF-919;HTF-919;Tegaserod (maleate)

Tegaserod Maleate is a potent full agonist at 5-HT4 receptors with an EC50 value of 7 nM, used to treat irritable bowel syndrome associated with constipation and chronic constipation.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit^[3]. Treatment with fluoxetine (10 mg/kg/day, days 36-42), tegaserod (1 mg/kg/day, day 43), or the combination of both, reduced visceral hypersensitivity and plasma 5-HT levels^[4]. Intravenous or intraduodenal tegaserod (0.3-1.0 mg/kg) had no inhibitory effect on mesenteric and colonic blood flow. Peroral treatment of rats with alosetron or tegaserod for 7 days did not modify mesenteric haemodynamics at baseline and after blockade of nitric oxide synthesis^[5]. Moreover, tegaserod has also been shown to improve symptoms, enhance gastric accommodation and significantly attenuate visceral pain arising from the colon in functional dyspepsia patients. Treatment with tegaserod seems also to exert a protective effect in inflamed colons, reducing the severity of colitis in animal models^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00693732	Irritable Bowel Syndrome	Phase 4	Completed	-	Singapore ... more >> NUH Singapore, Singapore, 117597 National University Hospital Singapore, Singapore, 119074 Collapse <<
NCT00141089	Chronic Constipation	Phase 3	Completed	-	-
NCT00511771	-	-	-	-	-

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3954 mL
- 11.9772 mL
- 23.9545 mL
- 5 mM
- 0.4791 mL
- 2.3954 mL
- 4.7909 mL
- 10 mM
- 0.2395 mL
- 1.1977 mL
- 2.3954 mL

技术信息

CAS号

189188-57-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H27N5O5

运输

蓝冰

分子量

417.46

别名

SDZ-HTF-919;HTF-919;Tegaserod (maleate);Zelnorm;马来酸替加色罗

溶解度

DMSO	190.0 mg/mL (455.1 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Tegaserod maleate/马来酸替加色罗 Catalog No. CSN16726

靶点选择性

请登录您的专属账户

确认信息