|5-羟基-7-甲氧基-2-苯基-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 520-28-5

Tectochrysin Catalog No. CSN10060

Synonyms: Techtochrysin;NSC 80687;5-Hydroxy-7-methoxyflavone

Tectochrysin, a natural product isolated and purified from the heartwood of Pinus strobus L., leads to apoptotic cell death in NSCLC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Tectochrysin is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin (at 1, 5, 10 μg/mL) suppressed the growth of SW480 and HCT116 human colon cancer cells. Tectochrysin inhibits SW480 cells growth with IC50 value of 6.3 μg/mL and HCT116 cells growth with IC50 value of 8.4 μg/mL. Morphologic observation shows that the cells are reduced in size by the treatment of NSC 80687 (10 μg/mL) in SW480 cells and HCT116 cells. Tectochrysin treatment also inhibited activity of NF-κB. Techtochrysin binds directly to the p50 unit. Tectochrysin concentration-dependently inhibits the translocation of p50 and p65 into the nucleus through inhibition of the phosphorylation of IκB. In vivo, tumor weights and volumes in mice were reduced when treated with tectochrysin (5 mg/kg). Tectochrysin leads to apoptotic cell death in colon cancer cells through activation of death receptors expression via the inhibition of NF-κB^[3]. 1 mM tectochrysin was sufficient to fully sensitize mutant ABCG2-transfected cells, whereas higher concentrations were required for the wild-type ones^[4]. Tectochrysin could inhibit the differentiation of BMMCs into osteoclasts induced by receptor activator of nuclear factor-κΒ ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) in a concentration-dependent manner in vitro^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7277 mL
- 18.6383 mL
- 37.2767 mL
- 5 mM
- 0.7455 mL
- 3.7277 mL
- 7.4553 mL
- 10 mM
- 0.3728 mL
- 1.8638 mL
- 3.7277 mL

技术信息

CAS号	520-28-5	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H12O4	运输	蓝冰
分子量	268.26	别名	Techtochrysin;NSC 80687;5-Hydroxy-7-methoxyflavone;杨芽黄素

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Tectochrysin Catalog No. CSN10060

靶点选择性

请登录您的专属账户

确认信息