|3((4-氯苯基)磺酰基)-N,N-二乙基-7,8-二甲氧基-[1,2,3]三唑并[1,5-a]喹唑啉-5-胺|CsnPharm

CAS No.: 1200443-21-5

Targocil Catalog No. CSN21222

Synonyms: QC-993

Targocil is a novel antibiotics against Methicillin-resistant Staphylococcus aureus (MRSA).

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技术信息

生物活性

描述Targocil functions as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) with MIC90s of 2 μg/ mL for both MRSA and MSSA. MICs of Targocil against S. aureus strains Newman, MW2, MG2375, and MG2389 are 1 μg/mL for all strains. Targocil shows excellent activity against S. aureus isolates from suspected cases of bacterial keratitis, including both MSSA and MRSA isolates, with MICs that range from 1 to 2 μg/ mL. Targocil activity was moderately sensitive to the presence of serum, but it inhibited extracellular and intracellular bacteria in the presence of HCECs (human corneal epithelial cells) better than vancomycin. Targocil-resistant strains exhibited a significantly reduced ability to adhere to HCECs^[1]. Targocil inhibited intracellular bacteria in the presence of human corneal epithelial cells to a greater extent than vancomycin. Targocil-resistant strains exhibited a significantly reduced ability to adhere to human corneal epithelial cells^[2].
参考文献

[1] Suzuki T, Swoboda JG, Campbell J, Walker S, Gilmore MS. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011;55(2):767‐774
[2] Suzuki T. A new target for Staphylococcus aureus associated with keratitis. Cornea. 2011;30 Suppl 1:S34‐S40

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1011 mL
- 10.5053 mL
- 21.0107 mL
- 5 mM
- 0.4202 mL
- 2.1011 mL
- 4.2021 mL
- 10 mM
- 0.2101 mL
- 1.0505 mL
- 2.1011 mL

技术信息

CAS号

1200443-21-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22ClN5O4S

运输

蓝冰

分子量

475.95

别名

QC-993

溶解度

DMSO	30.0 mg/mL (63.0 mM) warming
Water	Insoluble

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