112457-95-1|Tandospirone citrate|CsnPharm

CAS No.: 112457-95-1

Tandospirone citrate/坦度螺酮柠檬酸盐 Catalog No. CSN17480

Synonyms: SM-3997 citrate;坦度螺酮柠檬酸盐

Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).

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技术信息

生物活性

描述Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). IC50 Value: 27±5 nM(Ki)^[3]. Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A])^[4]. Chronic treatment with tandospirone, at 0.2 and 1.0mg/kg/day, but not 2.0mg/kg/day, attenuated footshock stress-induced eLAC (extracellular lactate concentrations) elevation in the mPFC (medial prefrontal cortex)^[5]. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01614041	Generalized Anxiety Disorder	Phase 4	Unknown	December 2017	China ... more >> Shanghai Tongji Hospital Recruiting Shanghai, China, 200065 Contact: Wenyuan Wu, MD Collapse <<
NCT03151382	Alzheimer Disease ... more >> Cognitive Function Collapse <<	Phase 4	Not yet recruiting	June 30, 2018	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7373 mL
- 8.6864 mL
- 17.3728 mL
- 5 mM
- 0.3475 mL
- 1.7373 mL
- 3.4746 mL
- 10 mM
- 0.1737 mL
- 0.8686 mL
- 1.7373 mL

技术信息

CAS号

112457-95-1

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H37N5O9

运输

蓝冰

分子量

575.61

别名

SM-3997 citrate;坦度螺酮柠檬酸盐

溶解度

Water

10.0 mg/mL (17.4 mM) warming

动物实验配方

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Tandospirone citrate/坦度螺酮柠檬酸盐 Catalog No. CSN17480

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