CAS No.: 1315330-11-0
TAK1/MAP4K2 inhibitor 1 Catalog No. CSN13581
B-Raf inhibitor, a pyrazine and pyrrolo[2,3-b]pyridine derivative, is useful in the treatment of cancer and proliferative diseases.
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NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03181100 Malignant Neoplasms of Thyroid... more >> and Other Endocrine Glands Anaplastic Thyroid Carcinoma Poorly Differentiated Thyroid Cancer Collapse << Phase 2 Recruiting July 2023 United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations mcabani@mdanderson.org Contact mcabani@mdanderson.org Collapse << NCT01978236 Melanoma and Brain Metastases Phase 2 Terminated(This study was term... more >>inated due to the limited enrollment.) Collapse << - United States, Pennsylvania ... more >> GSK Investigational Site Pittsburgh, Pennsylvania, United States, 15232 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Australia, New South Wales GSK Investigational Site North Sydney, New South Wales, Australia, 2060 Collapse << NCT01738451 Cancer Phase 1 Completed - United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Tennessee GSK Investigational Site Memphis, Tennessee, United States, 38120 GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site San Antonio, Texas, United States, 78229 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112-5550 Australia, Victoria GSK Investigational Site Heidelberg, Victoria, Australia, 3084 GSK Investigational Site Melbourne, Victoria, Australia, 3004 United Kingdom GSK Investigational Site London, United Kingdom, W1G 6AD Collapse << - 更多
- 参考文献
- [1] Herr R, Kohler M, et al. B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Res. 2015 Jan 1;75(1):216-29.
- [2] Arora R, Di Michele M, et al. Structural investigation of B-Raf paradox breaker and inducer inhibitors. J Med Chem. 2015 Feb 26;58(4):1818-31.
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技术信息
| CAS号 | 1315330-11-0 | 储存条件 |
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| 分子式 | C29H31F3N6O2 | 运输 | 蓝冰 | |
| 分子量 | 552.59 | 别名 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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| NCT03181100 | Malignant Neoplasms of Thyroid... more >> and Other Endocrine Glands Anaplastic Thyroid Carcinoma Poorly Differentiated Thyroid Cancer Collapse << | Phase 2 | Recruiting | July 2023 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations mcabani@mdanderson.org Contact mcabani@mdanderson.org Collapse << |
| NCT01978236 | Melanoma and Brain Metastases | Phase 2 | Terminated(This study was term... more >>inated due to the limited enrollment.) Collapse << | - | United States, Pennsylvania ... more >> GSK Investigational Site Pittsburgh, Pennsylvania, United States, 15232 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Australia, New South Wales GSK Investigational Site North Sydney, New South Wales, Australia, 2060 Collapse << |
| NCT01738451 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Tennessee GSK Investigational Site Memphis, Tennessee, United States, 38120 GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site San Antonio, Texas, United States, 78229 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112-5550 Australia, Victoria GSK Investigational Site Heidelberg, Victoria, Australia, 3084 GSK Investigational Site Melbourne, Victoria, Australia, 3004 United Kingdom GSK Investigational Site London, United Kingdom, W1G 6AD Collapse << |
| NCT01978236 | - | - | Terminated(This study was term... more >>inated due to the limited enrollment.) Collapse << | - | - |
| NCT01682083 | Melanoma | Phase 3 | Active, not recruiting | November 30, 2030 | - |
| NCT01682083 | - | - | Active, not recruiting | - | - |
| NCT03176485 | Metastatic Cancer ... more >> Melanoma Colon Cancer Differentiated Thyroid Cancer Hepatocellular Carcinoma Renal Cell Carcinoma Metastatic Melanoma HCC Metastatic Colon Cancer Collapse << | Not Applicable | Recruiting | November 1, 2018 | United States, Arizona ... more >> University of Arizona Cancer Center Recruiting Tucson, Arizona, United States, 85724 Contact: Clara Curiel-Lewandroski ccuriel@email.arizona.edu Collapse << |
| NCT01909453 | Melanoma | Phase 3 | Active, not recruiting | March 31, 2019 | - |
| NCT01231568 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Michigan GSK Investigational Site Detroit, Michigan, United States, 48201 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112 Collapse << |
| NCT01266967 | Melanoma and Brain Metastases | Phase 2 | Completed | - | - |
| NCT01266967 | - | - | Completed | - | - |
| NCT01689519 | Malignant Melanoma | Phase 3 | Active, not recruiting | December 28, 2019 | - |
| NCT02425904 | Langerhans Cell Histiocytosis | Phase 2 | Recruiting | September 2022 | United States, Arizona ... more >> Phoenix Children's Hospital Recruiting Phoenix, Arizona, United States, 85016 Contact: Michael Henry, MD 602-933-0920 MHenry@phoenixchildrens.com United States, Arkansas Arkansas Children's Hospital Recruiting Little Rock, Arkansas, United States, 72202 Contact: Kimo Stine, MD 501-364-1494 StineKimoC@uams.edu United States, California Children's Hospital of Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Rima Jubran, MD 323-361-5639 rjubran@chla.usc.edu University of California San Francisco Medical Center Recruiting San Francisco, California, United States, 94143 Contact: Michelle Hermiston, MD 415-476-3831 HermistonM@peds.ucsf.edu United States, District of Columbia Children's National Medical Center Recruiting Washington, District of Columbia, United States, 20010 Contact: Stephen Ladisch, MD sladisch@childrensnational.org United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: David Ebb, MD 617-726-2737 DEBB@mgh.harvard.edu Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Barbara Degar, MD 617-632-5186 Barbara_Degar@dfci.harvard.edu Principal Investigator: Barbara Degar, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Barbara Degar, MD 617-632-5186 barbara_degar@dfci.harvard.edu Principal Investigator: Barbara Degar, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Eric Jacobsen, MD 617-632-6633 EdJacobsen@partners.org United States, New York Mount Sinai Medical Center Recruiting New York, New York, United States, 10029 Contact: Birte Wistinghausen, MD 212-241-7022 Birte.wistinghausen@mssm.edu United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Ashish Kumar, MD 513-803-1631 Ashish.Kumar@cchmc.org United States, Pennsylvania The Children's Hospital of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Michael Hogarty, MD 215-590-2821 hogartym@email.chop.edu United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Patrick Campbell, MD patrick.campbell@stjude.org Principal Investigator: Patrick Campbell, MD United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Carl Allen, MD 832-822-4890 ceallen@txch.org Collapse << |
| NCT01940809 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 1 | Active, not recruiting | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01689519 | - | - | Active, not recruiting | - | - |
| NCT03430947 | Malignant Melanoma Stage IV ... more >> BRAF V600 Mutation Brain Metastases Collapse << | Phase 2 | Recruiting | August 31, 2021 | Germany ... more >> Technische Universität Dresden Recruiting Dresden, Germany, 01307 Contact: Friedegund Meier, MD +49 351 458 ext 2497 friedegund.meier@uniklinikum-dresden.de Contact: Esther Troost, MD +49 351 458 ext 2394 esther.troost@uniklinikum-dresden.de Principal Investigator: Friedegund Meier, MD Principal Investigator: Esther Troost, MD, PhD Ruprecht-Karls-University of Heidelberg, Faculty of Medicine Not yet recruiting Heidelberg, Germany, 69120 Contact: Jessica Hassel, MD Eberhard Karls University of Tübingen, University Medical Center Not yet recruiting Tuebingen, Germany, 72076 Contact: Thomas Eigentler, MD Collapse << |
| NCT01262963 | Cancer | Phase 1 | Completed | - | United States, Washington ... more >> GSK Investigational Site Tacoma, Washington, United States, 98418 Collapse << |
| NCT03088176 | Melanoma BRAF... more >> Gene Mutation Collapse << | Phase 1 | Recruiting | June 30, 2021 | United States, Tennessee ... more >> West Cancer Center Recruiting Germantown, Tennessee, United States, 38138 Contact: Ari VanderWalde, MD, MPH 901-683-0055 ext 63015 avanderw@westclinic.com Contact: Nibedita Chakraborty 901-683-0055 ext 63023 nchakraborty@westclinic.com Collapse << |
| NCT03101254 | Melanoma | Phase 1 Phase 2 | Recruiting | October 30, 2023 | United States, Massachusetts ... more >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Elizabeth Buchcinder, MD 617-632-5055 Principal Investigator: Elizabeth Buchbinder, MD Collapse << |
| NCT03618641 | Melanoma Lymp... more >>h Node Cancer Collapse << | Phase 2 | Recruiting | July 15, 2023 | United States, Pennsylvania ... more >> UPMC Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Diwakar Davar, MD 412-623-7368 davard@upmc.edu Contact: Amy Rose, RN 412-647-8587 kennaj@upmc.edu Collapse << |
| NCT02837263 | Colorectal Cancer ... more >> Colorectal Adenocarcinoma Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer Metastatic Carcinoma in the Liver Collapse << | Phase 1 | Recruiting | June 2021 | United States, Wisconsin ... more >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Dustin Deming Collapse << |
| NCT01840527 | - | - | Active, not recruiting | March 2019 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01585415 | Metastatic Cancer ... more >> Melanoma Collapse << | Phase 1 | Terminated | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT02367859 | Ameloblastoma ... more >> BRAF Gene Mutation Collapse << | Phase 2 | Recruiting | August 2020 | United States, California ... more >> Stanford University, School of Medicine Recruiting Stanford, California, United States, 94305 Contact: Elizabeth Winters 650-721-6509 ewinters@stanford.edu Principal Investigator: Alexander D. Colevas Sub-Investigator: Jonathan Pollack Sub-Investigator: Davud Sirjani Sub-Investigator: Robert West Collapse << |
| NCT02910700 | BRAF Gene Mutation ... more >> BRAF wt Allele Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 2 | Recruiting | December 31, 2021 | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Hussein A. Tawbi 713-792-2921 Principal Investigator: Hussein A. Tawbi Collapse << |
| NCT01231594 | Cancer | Phase 1 | Completed | - | - |
| NCT02097225 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Malignant Solid Neoplasm Metastatic Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Unresectable Solid Neoplasm Collapse << | Phase 1 | Recruiting | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Recruiting Boston, Massachusetts, United States, 02114 Contact: Ryan J. Sullivan 617-724-4000 rsullivan7@partners.org Principal Investigator: Ryan J. Sullivan Dana-Farber Cancer Institute Suspended Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01989585 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Melanoma Solid Neoplasm Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 1 Phase 2 | Recruiting | - | United States, California ... more >> University of California Davis Comprehensive Cancer Center Suspended Sacramento, California, United States, 95817 United States, Massachusetts Massachusetts General Hospital Cancer Center Withdrawn Boston, Massachusetts, United States, 02114 United States, Missouri Siteman Cancer Center at West County Hospital Suspended Creve Coeur, Missouri, United States, 63141 Washington University School of Medicine Suspended Saint Louis, Missouri, United States, 63110 Siteman Cancer Center-South County Suspended Saint Louis, Missouri, United States, 63129 Siteman Cancer Center at Christian Hospital Suspended Saint Louis, Missouri, United States, 63136 Siteman Cancer Center at Saint Peters Hospital Suspended Saint Peters, Missouri, United States, 63376 United States, New Jersey Rutgers Cancer Institute of New Jersey Recruiting New Brunswick, New Jersey, United States, 08903 Contact: Site Public Contact 732-235-8675 Principal Investigator: Janice M. Mehnert United States, North Carolina Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Site Public Contact 888-275-3853 Principal Investigator: James L. Abbruzzese United States, Ohio Ohio State University Comprehensive Cancer Center Recruiting Columbus, Ohio, United States, 43210 Contact: Site Public Contact 800-293-5066 Jamesline@osumc.edu Principal Investigator: Kari L. Kendra United States, Texas M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Site Public Contact 877-312-3961 Principal Investigator: Michael A. Davies Collapse << |
| NCT03493932 | Glioblastoma | Phase 1 | Recruiting | June 1, 2021 | United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Collapse << |
| NCT02475213 | Melanoma Head... more >> and Neck Cancer Non Small Cell Lung Cancer Urethelial Carcinoma Collapse << | Phase 1 | Recruiting | August 2020 | United States, Arizona ... more >> Mayo Clinic - AZ Not yet recruiting Scottsdale, Arizona, United States, 85259 Principal Investigator: Ramesh Ramanathan, MD United States, Florida Boca Raton Regional Hospital Not yet recruiting Boca Raton, Florida, United States, 33486 Principal Investigator: Edgardo Santos Castillero, MD Mayo Clinic - FL Not yet recruiting Jacksonville, Florida, United States, 32224 Principal Investigator: Yanyan Lou, MD, PhD Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Kristina Trajic 813-745-4673 ext 1480 Kristina.trajic@moffitt.org Principal Investigator: Scott Antonia, MD United States, Kentucky Norton Cancer Institute Research Program Active, not recruiting Louisville, Kentucky, United States, 40202 United States, Maryland University of Maryland Greenbaum Cancer Center Recruiting Baltimore, Maryland, United States, 21201 Contact: Cheryl Young Cheryl.Young@umm.edu Principal Investigator: Dan Zandberg, MD United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Tess Ferguson 617-632-1991 tessk_ferguson@dfci.harvard.edu Principal Investigator: Osama Rahma, MD United States, Michigan South Texas Accelerated Research Therapeutics, LLC - Midwest Recruiting Grand Rapids, Michigan, United States, 49503 Contact: Kathy Estkowski 616-954-5551 kathy.estkowski@startmidwest.com Principal Investigator: Nehal Lakhani, MD, PhD United States, Minnesota Mayo Clinic - MN Not yet recruiting Rochester, Minnesota, United States, 55905 Principal Investigator: Alex Adjei, MD, PhD United States, Nebraska Nebraska Cancer Specialists Recruiting Omaha, Nebraska, United States, 68130 Contact: Gladys Pierce 402-690-6972 gpierce@nebraskacancer.com Principal Investigator: Ralph Hauke, MD United States, Nevada Comprehensive Cancer Centers of Nevada Recruiting Las Vegas, Nevada, United States, 89169 Contact: Kim Bradstreet, RN 702-952-3443 kimberly.bradstreet@usoncology.com Principal Investigator: Nicholas Vogelzang, MD United States, New York Roswell Park Cancer Institute Not yet recruiting Buffalo, New York, United States, 14263 Contact: Dawn DePaolo DawnMarie.DePaolo@RoswellPark.org Principal Investigator: Gurkamal Chatta, MD Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Molly McGuinness 212-304-5552 mm5016@cumc.columbia.edu Principal Investigator: Naiyer Rizvi, MD United States, Ohio Gabrail Cancer Institute Not yet recruiting Canton, Ohio, United States, 44718 Principal Investigator: Nashat Gabrail, MD United States, Pennsylvania Hospital of the University of Pennsylvania/Abramson Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Maryann Ghallagher, RN 215-662-7758 maryann.gallagher@uphs.upenn.edu Principal Investigator: Charu Aggarwal, MD University of Pittsburg Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Shea McQuilkin, BSN, RN 412-623-6650 mcquilkinm@upmc.edu Principal Investigator: Robert Ferris, MD United States, Rhode Island Rhode Island Hospital Not yet recruiting Providence, Rhode Island, United States, 02903 Principal Investigator: Ariel Birnbaum, MD United States, South Carolina Greenville Health System Not yet recruiting Greenville, South Carolina, United States, 29605 Contact: Lisa Johnson 864-455-3735 ljohnson4@ghs.org Principal Investigator: Jeffery Edenfield, MD United States, Texas Mary Crowley Cancer Research Center Not yet recruiting Dallas, Texas, United States, 75230 Principal Investigator: James Strauss, MD South Texas Accelerated Research Therapeutics, LLC Recruiting San Antonio, Texas, United States, 78229 Contact: Christina Duralde, RN, MSN 210-593-5242 christina.duralde@start.stoch.com Principal Investigator: Anthony Tolcher, M.D. Collapse << |
| NCT01902173 | Adult Solid Neoplasm ... more >> Recurrent Colon Carcinoma Recurrent Melanoma Recurrent Ovarian Carcinoma Stage IIIC Colon Cancer Stage IIIC Ovarian Cancer Stage IIIC Skin Melanoma Stage IV Skin Melanoma Collapse << | Phase 1 Phase 2 | Suspended(Temporarily stopped ... more >>for assessment. Contact ctsucontact@westat.com for specifics) Collapse << | - | United States, California ... more >> USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 California Pacific Medical Center-Pacific Campus San Francisco, California, United States, 94115 UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, Colorado University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Oregon Clackamas Radiation Oncology Center Clackamas, Oregon, United States, 97015 Providence Milwaukie Hospital Milwaukie, Oregon, United States, 97222 Providence Newberg Medical Center Newberg, Oregon, United States, 97132 Providence Willamette Falls Medical Center Oregon City, Oregon, United States, 97045 Providence Portland Medical Center Portland, Oregon, United States, 97213 Providence Saint Vincent Medical Center Portland, Oregon, United States, 97225 Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Washington PeaceHealth Southwest Medical Center Vancouver, Washington, United States, 98664 Collapse << |
| NCT03026517 | Melanoma | Phase 1 | Recruiting | January 2020 | United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Keith Flaherty, MD 617-724-4800 United States, New York Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Paul Chapman, MD 646-888-4162 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul Chapman, MD 646-888-4162 Contact: Michael Postow, MD 646-888-4589 Principal Investigator: Paul Chapman, MD Collapse << |
| NCT01777776 | Locally Advanced Metastatic BR... more >>AF Mutant Melanoma Collapse << | Phase 1 Phase 2 | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | United States, Colorado ... more >> University of Colorado Dept of Oncology Aurora, Colorado, United States, 80045 United States, Michigan Karmanos Cancer Institute Dept of Oncology Detroit, Michigan, United States, 48201 United States, New York Memorial Sloan Kettering Cancer Center Dept Oncology NY, New York, United States, 90033 United States, Oregon Oregon Health & Science University Dept. of OHSU (3) Portland, Oregon, United States, 97239 United States, Tennessee Vanderbilt University Medical Center SC - Dept of Oncology . Nashville, Tennessee, United States, 37232 Australia, New South Wales Novartis Investigative Site Westmead, New South Wales, Australia, 2145 Australia, South Australia Novartis Investigative Site Woodville, South Australia, Australia, 5011 Canada, Quebec Novartis Investigative Site Montreal, Quebec, Canada, H2X 3J4 Netherlands Novartis Investigative Site Utrecht, Netherlands, 3584CX Collapse << |
| NCT01777776 | - | - | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | - |
| NCT01947023 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Metastatic Thyroid Gland Carcinoma Unresectable Thyroid Gland Carcinoma Collapse << | Phase 1 | Active, not recruiting | - | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01723202 | Follicular Thyroid Cancer ... more >> Insular Thyroid Cancer Papillary Thyroid Cancer Recurrent Thyroid Cancer Collapse << | Phase 2 | Active, not recruiting | December 31, 2019 | United States, California ... more >> University of California, San Diego San Diego, California, United States, 92093-0698 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Massachusetts Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, United States, 02114 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas The University of Texas-MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01907802 | BRAF Gene Mutation ... more >> Hepatic Complication Renal Failure Solid Neoplasm Collapse << | Phase 1 | Terminated | - | United States, California ... more >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Colorado University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Canada, Ontario University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT02231775 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Collapse << | Phase 2 | Recruiting | October 31, 2019 | United States, Texas ... more >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Jennifer Wargo 713-745-1553 Principal Investigator: Jennifer Wargo Collapse << |
| NCT01826448 | V600-mutated BRAF Unresectable... more >> Melanoma V600-mutated BRAF Metastatic Melanoma Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor Collapse << | Phase 1 | Terminated | - | United States, California ... more >> UCLA Los Angeles, California, United States, 90024 United States, Colorado University of Colorado, Denver Aurora, Colorado, United States, 80012 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 France Institute Gustave Roussy Paris, France Germany University Hospital Essen Essen, Germany Collapse << |
| NCT01713972 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Active, not recruiting | December 31, 2019 | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02196181 | BRAF V600E Mutation Present ... more >> BRAF V600K Mutation Present Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Unresectable Melanoma Collapse << | Phase 2 | Recruiting | - | - |
| NCT02416232 | - | - | - | - | France ... more >> GSK Investigational Site Amiens Cedex, France, 80054 GSK Investigational Site Angers, France, 49100 GSK Investigational Site Bayonne cedex, France, 64109 GSK Investigational Site Besancon cedex, France, 25030 GSK Investigational Site Bobigny, France, 93000 GSK Investigational Site Bordeaux, France, 33075 GSK Investigational Site Boulogne-Billancourt, France, 92100 GSK Investigational Site Brest cedex, France, 29609 GSK Investigational Site Caen Cedex 9, France, 14033 GSK Investigational Site Chambray-Les-Tours, France, 37170 GSK Investigational Site Clermont-Ferrand cedex 1, France, 63003 GSK Investigational Site Creteil, France, 94010 GSK Investigational Site Dijon Cedex, France, 21079 GSK Investigational Site Grenoble cedex 9, France, 38043 GSK Investigational Site La Rochelle cedex 1, France, 17019 GSK Investigational Site Le Havre, France, 76083 GSK Investigational Site Le Mans, France, 72000 GSK Investigational Site Lille, France, 59037 GSK Investigational Site Limoges cedex, France, 87042 GSK Investigational Site Lorient, France, 56322 GSK Investigational Site Lyon Cedex 08, France, 69373 GSK Investigational Site Marseille Cedex 5, France, 13385 GSK Investigational Site Montpellier cedex 5, France, 34295 GSK Investigational Site Montpellier Cedex 5, France, 34298 GSK Investigational Site Mulhouse, France, 68100 GSK Investigational Site Nantes Cedex 1, France, 44093 GSK Investigational Site Nice, France, 06202 GSK Investigational Site Nimes, France, 30029 cedex 9 GSK Investigational Site Orleans Cedex 2, France, 45067 GSK Investigational Site Paris Cedex 10, France, 75475 GSK Investigational Site Paris, France, 75006 GSK Investigational Site Pau, France, 64000 GSK Investigational Site Pierre-Benite cedex, France, 69495 GSK Investigational Site Poitiers, France, 86021 GSK Investigational Site Pringy Cedex, France, 74374 GSK Investigational Site Reims Cedex, France, 51092 GSK Investigational Site Rennes Cedex, France, 35042 GSK Investigational Site Rouen, France, 76031 GSK Investigational Site Saint-Pierre, France, 97448 GSK Investigational Site Saint-Priest en Jarez, France, 42270 GSK Investigational Site Strasbourg Cedex, France, 67091 GSK Investigational Site Thionville, France, 57126 Cedex 1 GSK Investigational Site Toulouse Cedex 9, France, 31059 GSK Investigational Site Valence Cedex 9, France, 26953 GSK Investigational Site Vandoeuvre-Les-Nancy, France, 54511 GSK Investigational Site Villejuif cedex, France, 94805 Collapse << |
| NCT02700763 | Melanoma | Not Applicable | Recruiting | December 2019 | Netherlands ... more >> University Medical Center Groningen Recruiting Groningen, Netherlands, 9713 GZ Contact: Geke AP Hospers, MD, PhD +31 50 3612821 g.a.p.hospers@umcg.nl Principal Investigator: Geke A.P. Hospers, MD, PhD Collapse << |
| NCT02902042 | Malignant Melanoma | Phase 1 Phase 2 | Recruiting | March 2022 | Germany ... more >> Universitätsklinikum Freiburg Active, not recruiting Freiburg, Baden-Württemberg, Germany, 79106 Klinikum Augsburg Süd Not yet recruiting Augsburg, Bavaria, Germany, 86179 Principal Investigator: Christiane Pfeiffer, PD Dr. med. Klinikum rechts der Isar Recruiting München, Bavaria, Germany, 81675 Principal Investigator: Angela Krackhardt, Prof.Dr.med. Klinikum Nürnberg Nord Recruiting Nürnberg, Bavaria, Germany, 90419 Principal Investigator: Erwin S. Schultz, Prof.Dr.med. Vivantes Klinikum im Friedrichshain Active, not recruiting Berlin Friedrichshain, Berlin, Germany, 10249 Universitätsklinikum der RWTH Aachen Not yet recruiting Aachen, Nordrhein-Westfalen, Germany, 52074 Principal Investigator: Albert Rübben, Prof.Dr.med. University Hospital Essen, Department of Dermatology, Skin Cancer Center Recruiting Essen, North Rhine-Westphalia, Germany, 45122 Contact: Dirk Schadendorf, Prof. Dr. +49 (0) 201-723 ext 4342 dirk.schadendorf@uk-essen.de Principal Investigator: Dirk Schadendorf, Prof. Dr. Sub-Investigator: Lisa Zimmer, Dr. med. Sub-Investigator: Elisabeth Livingstone, Dr. med. HELIOS Klinikum Krefeld Recruiting Krefeld, North Rhine-Westphalia, Germany, 47805 Principal Investigator: Chalid Assaf, PD Dr. med. Gesellschaft für Klinische Forschung Ludwigshafen mbH Not yet recruiting Ludwigshafen am Rhein, Rheinland-Pfalz, Germany, 67063 Principal Investigator: Edgar Dippel, Prof.Dr.med. Städtisches Klinikum Dessau Recruiting Dessau, Saxony-Anhalt, Germany, 06847 Principal Investigator: Dietrich Trebing, Dr. med. Collapse << |
| NCT01543113 | Melanoma | Not Applicable | Completed | - | France ... more >> Centre Eugène Marquis Rennes, Bretagne, France, 35000 Rennes University Hospital Rennes, Bretagne, France, 35033 Collapse << |
| NCT02224781 | BRAF NP_004324.2:p.V600X ... more >> Metastatic Melanoma Recurrent Melanoma Stage III Cutaneous Melanoma AJCC v7 Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Collapse << | Phase 3 | Recruiting | - | - |
| NCT02263898 | Recurrent Melanoma ... more >> Stage IV Melanoma Collapse << | Phase 2 | Withdrawn(closed without enrol... more >>lment) Collapse << | - | United States, California ... more >> Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 Collapse << |
| NCT01820364 | Melanoma | Phase 2 | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | United States, Tennessee ... more >> Sarah Cannon Research Institute Onc Dept Nashville, Tennessee, United States, 37203 Australia, Victoria Novartis Investigative Site East Melbourne, Victoria, Australia, 3002 Canada, Alberta Novartis Investigative Site Edmonton, Alberta, Canada, T6G 1Z2 Germany Novartis Investigative Site Heidelberg, Germany, 69120 Spain Novartis Investigative Site Barcelona, Catalunya, Spain, 08035 Switzerland Novartis Investigative Site Zuerich, Switzerland, 8091 Collapse << |
| NCT02306850 | Unresectable Malignant Neoplas... more >>m Melanoma Metastatic Melanoma Stage IV Melanoma Stage III Melanoma Collapse << | Phase 2 | Recruiting | February 2019 | United States, Missouri ... more >> Saint Louis University Hospital Recruiting Saint Louis, Missouri, United States, 63101 Contact: Debra L King, RN 314-268-7061 richartstudy@gmail.com Principal Investigator: John M Richart, M.D. Collapse << |
| NCT01820364 | - | - | Terminated(Study was withdrawn... more >> due to scientific and business considerations.) Collapse << | - | - |
| NCT01582997 | Cancer | Phase 1 | Completed | - | Japan ... more >> GSK Investigational Site Shizuoka, Japan, 411-8777 GSK Investigational Site Tokyo, Japan, 104-0045 Collapse << |
| NCT01754376 | Melanoma | Phase 2 | Terminated(changes in availabl... more >>e treatments for melanoma) Collapse << | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02113 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01754376 | - | - | Terminated(changes in availabl... more >>e treatments for melanoma) Collapse << | - | - |
| NCT01400451 | Melanoma | Phase 1 | Terminated(More than 2 of 6 pa... more >>tients treated experienced dose limiting toxicities.) Collapse << | - | United States, California ... more >> University Of California Los Angeles Los Angeles, California, United States, 90095 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Dana Farber Cancer Inst Boston, Massachusetts, United States, 02215 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01701037 | Recurrent Melanoma ... more >> Stage IIB Melanoma (Locally Advanced) Stage IIC Melanoma (Locally Advanced) Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma (Limited, Resectable) Collapse << | Phase 2 | Terminated(PI leaving VICC, lo... more >>w future accrual predicted, continued funding improbable,) Collapse << | - | United States, Tennessee ... more >> Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232-6838 Collapse << |
| NCT01701037 | - | - | Terminated(PI leaving VICC, lo... more >>w future accrual predicted, continued funding improbable,) Collapse << | - | - |
| NCT00338377 | Melanoma | Phase 2 | Recruiting | February 2019 | United States, Texas ... more >> The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Patrick Hwu, MD 713-792-2921 phwu@mdanderson.org Principal Investigator: Patrick Hwu, MD Collapse << |
| NCT01400451 | - | - | Terminated(More than 2 of 6 pa... more >>tients treated experienced dose limiting toxicities.) Collapse << | - | - |
| NCT01721603 | BRAFV600E Melanoma Patients | Phase 2 | Terminated(Low accrual) | - | United States, California ... more >> University of San Francisco, California San Francisco, California, United States, 94115 Collapse << |
| NCT02452294 | Malignant Melanoma ... more >> Metastases Collapse << | Phase 2 | Recruiting | July 2018 | Germany ... more >> Department of Dermatology, University Hopsital Recruiting Dresden, Germany, 01307 Contact: Friedegund Meier, MD ++49 351 458 ext 3677 Friedegund.Meier@uniklinikum-dresden.de Department of Dermatology, University Hospital Recruiting Tuebingen, Germany, 72076 Contact: Claus Garbe, MD ++49 7071 29 ext 87110 claus.garbe@med.uni-tuebingen.de Contact: Thomas Eigentler, MD ++49 7071 29 ext 85748 thomas.eigentler@med.uni-tuebingen.de Collapse << |
| NCT01721603 | - | - | Terminated(Low accrual) | - | - |
| NCT02143050 | Melanoma | Phase 1 Phase 2 | Recruiting | June 2020 | United States, Kentucky ... more >> James Graham Brown Cancer Center-Universityof Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Jason A Chesney, MD, PhD 502-562-3429 jason.chesney@louisville.edu Contact: Christina LaDuke 502-217-5205 christy.laduke@louisville.edu Sub-Investigator: Donald M Miller, MD, PhD Sub-Investigator: Kelly M McMasters, MD, PhD Sub-Investigator: Sucheta Telang, MD James Graham Brown Cancer Center Recruiting Louisville, Kentucky, United States, 40202 Contact: Karen Carter, BSN 502-562-3690 kmcart05@louisville.edu Contact: Christina LaDuke, BS 502-217-5205 christi.laduke@louisville.edu Collapse << |
| NCT01700699 | - | - | Unknown | October 2013 | Italy ... more >> Department of Medicine and Surgery, Univeristy of Salerno Recruiting Baronissi, Salerno, Italy, 84081 Contact: Mario Vitale, MD +39 089672539 mavitale@unisa.it Principal Investigator: Mario Vitale, MD Collapse << |
| NCT01495988 | - | - | Terminated(Slow accrual; toxic... more >>ity; change in priorities) Collapse << | - | - |
| NCT02052193 | Metastatic Melanoma (Carrying ... more >>BRAF V600 Mutation) Collapse << | Phase 2 | Terminated(Second cohort not o... more >>pened because Simon-Two_Step model failed) Collapse << | December 2017 | Germany ... more >> Department of Dermatology Tuebingen, BW, Germany, 72076 Collapse << |
| NCT01495988 | Melanoma Meta... more >>static Melanoma Collapse << | Phase 2 | Terminated(Slow accrual; toxic... more >>ity; change in priorities) Collapse << | - | United States, California ... more >> The Angeles Clinic Los Angeles, California, United States, 90025 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown Lombardi Comprehensive Cancer Center Washington, D.C., District of Columbia, United States, 20007 Washington Cancer Institute at MedStar Washington Hospital Center Washington, D.C., District of Columbia, United States, 20010 United States, Maryland Harry and Jeannette Weinberg Cancer Institute at Franklin Square Baltimore, Maryland, United States, 21237 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center (BIDMC) Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York NYU Clinical Cancer Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, Ohio OSU Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98109 Collapse << |
| NCT02427893 | Melanoma | Phase 3 | Withdrawn(no patients were enr... more >>olled) Collapse << | - | United States, Maryland ... more >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 Collapse << |
| NCT01719380 | Colorectal Cancer | Phase 1 Phase 2 | Active, not recruiting | July 31, 2019 | - |
| NCT01340846 | Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> GSK Investigational Site Scottsdale, Arizona, United States, 85259 United States, Florida GSK Investigational Site Sarasota, Florida, United States, 34232 United States, Michigan GSK Investigational Site Detroit, Michigan, United States, 48201 United States, Ohio GSK Investigational Site Columbus, Ohio, United States, 43210 United States, Oklahoma GSK Investigational Site Oklahoma City, Oklahoma, United States, 73104 United States, South Carolina GSK Investigational Site Greenville, South Carolina, United States, 29605 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 United Kingdom GSK Investigational Site Headington, United Kingdom, OX3 7LJ GSK Investigational Site London, United Kingdom, W1G 6AD Collapse << |
| NCT01340833 | Cancer | Phase 1 | Completed | - | United States, Washington ... more >> GSK Investigational Site Tacoma, Washington, United States, 98418 Collapse << |
| NCT01758575 | - | - | Terminated | - | Netherlands ... more >> VU University Medical Center Amsterdam, Netherlands, 1081HV Collapse << |
| NCT02354690 | Metastatic Melanoma | Phase 1 Phase 2 | Active, not recruiting | August 2020 | Denmark ... more >> Center for Cancer Immune Therapy, Dept. of Haematology/Oncology Copenhagen, Herlev, Denmark, 2730 Collapse << |
| NCT02967692 | Melanoma | Phase 3 | Recruiting | February 13, 2020 | - |
| NCT02649972 | Histiocytic Disorders | Phase 2 | Recruiting | January 2019 | United States, New York ... more >> Memoral Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eli Diamond, MD 212-639-7576 Contact: David Hyman, MD 646-888-4544 Principal Investigator: Eli Diamond, MD Collapse << |
| NCT01143753 | Neoplasms | Phase 1 | Completed | - | Australia, South Australia ... more >> Royal Adelaide Hospital; Oncology Adelaide, South Australia, Australia, 5000 Australia, Victoria Austin Hospital; Medical Oncology Heidelberg, Victoria, Australia, 3084 Royal Melbourne Hospital; Hematology and Medical Oncology Parkville, Victoria, Australia, 3052 Denmark Rigshospitalet, Onkologisk Klinik København Ø, Denmark, 2100 Spain Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona, Spain, 08035 Collapse << |
| NCT02281760 | BRAF V600E Mutation | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT01596140 | Advanced Cancer ... more >> Solid Tumor Collapse << | Phase 1 | Active, not recruiting | December 2020 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02836548 | Melanoma Skin... more >> Neoplasms Collapse << | Phase 1 Phase 2 | Recruiting | October 2019 | Netherlands ... more >> Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Recruiting Amsterdam, Netherlands, 1066 CX Contact: N Steeghs, MD, PhD Collapse << |
| NCT01519427 | Recurrent Melanoma ... more >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Collapse << | Phase 2 | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | United States, Georgia ... more >> Emory University Atlanta, Georgia, United States, 30322 United States, New Jersey Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Collapse << |
| NCT02382549 | Melanoma | Phase 1 Phase 2 | Recruiting | June 2020 | United States, Virginia ... more >> Cancer Center at the University of Virginia Recruiting Charlottesville, Virginia, United States, 22908 Collapse << |
| NCT02610361 | Solid Tumors | Phase 1 | Completed | - | Australia, New South Wales ... more >> Chris O'Brien Lifehouse Camperdown, New South Wales, Australia, 2050 North Coast Cancer Institute Port Macquarie, New South Wales, Australia, 2444 Prince of Wales Hospital Randwick, New South Wales, Australia, 2031 Westmead Hospital Westmead, New South Wales, Australia, 2145 Australia, Queensland Tasman Oncology Research Ltd Southport, Queensland, Australia, 4215 Princess Alexandra Hospital Woolloongabba, Queensland, Australia, 4102 Australia, South Australia Royal Adelaide Hospital Adelaide, South Australia, Australia, 5000 The Queen Elizabeth Hospital Woodville South, South Australia, Australia, 5011 Australia, Victoria Box Hill Hospital Box Hill, Victoria, Australia, 3128 Monash Medical Centre Clayton, Victoria, Australia, 3168 Austin Health Heidelberg, Victoria, Australia Cabrini Hospital Malvern, Victoria, Australia, 3144 The Alfred Hospital Melbourne, Victoria, Australia, 3004 Peter MacCallum Cancer Centre Melbourne, Victoria, Australia Royal Melbourne Hospital Parkville, Victoria, Australia Australia, Western Australia Linear Clinical Research Limited Nedlands, Western Australia, Australia, 6009 New Zealand Christchurch Hospital Christchurch, New Zealand, 8011 Dunedin Public Hospital Dunedin, New Zealand, 9106 Waikato Hospital Hamilton, New Zealand Wellington Hospital Wellington, New Zealand Collapse << |
| NCT01286753 | Neoplasms | Phase 2 | Completed | - | United States, California ... more >> Torrance, California, United States, 90502 United States, Connecticut New Haven, Connecticut, United States, 06510 United States, Illinois Chicago, Illinois, United States, 60637 United States, Maryland Baltimore, Maryland, United States, 21231 United States, Massachusetts Boston, Massachusetts, United States, 02114 Boston, Massachusetts, United States, 02215 United States, New York New York, New York, United States, 10017 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas Houston, Texas, United States, 77030 France Lyon, France, 69008 Paris, France, 75651 Villejuif, France, 94805 Italy Milano, Lombardia, Italy, 20133 Pisa, Toscana, Italy, 56124 Netherlands Groningen, Netherlands, 9700 RB Leiden, Netherlands, 2300 RC Collapse << |
| NCT01286753 | - | - | Completed | - | - |
| NCT02310451 | Metastatic Melanoma | Not Applicable | Unknown | December 2016 | France ... more >> CHU de Nice ^Hôpital de l'Archet Recruiting Nice, France, 06200 Contact: Vanina OLIVERI, CRA 0033 4 92 03 42 54 oliveri.v@chu-nice.fr Collapse << |
| NCT01519427 | - | - | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | - |
| NCT01531361 | Advanced Malignant Neoplasm ... more >> BRAF Gene Mutation Metastatic Malignant Neoplasm Recurrent Malignant Neoplasm Refractory Malignant Neoplasm Collapse << | Phase 1 | Active, not recruiting | February 28, 2020 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02456701 | Thyroid Cancer | Phase 1 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01336634 | Cancer | Phase 2 | Active, not recruiting | December 1, 2020 | - |
| NCT01336634 | - | - | Active, not recruiting | - | - |
| NCT02410863 | Malignant Melanoma | Phase 2 | Terminated(lack of recruitment... more >> due to changed therapy options) Collapse << | - | Germany ... more >> National Centre for Tumour Diseases (NCT) Heidelberg, BW, Germany, 69120 University Hospital Tübingen Tübingen, BW, Germany, 72076 Elbe Kliniken Stade - Buxtehude GmbH, Clinic for Dermatology Buxtehude, Lower Saxony, Germany, 21614 University Hospital Essen Essen, NRW, Germany, 45147 University Hospital Mainz, Clinic for Dermatology Mainz, Rhineland-Palatinate, Germany, 55131 Universitätsklinik Carl Gustav Carus der Technischen Universität Dresden Dresden, Saxony, Germany, 01307 Collapse << |
| NCT01835184 | Recurrent Melanoma ... more >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Terminated | - | United States, Georgia ... more >> Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Virginia Virginia Commonwealth University Richmond, Virginia, United States, 23298 Collapse << |
| NCT01616199 | Advanced BRAF-mutant Cancers | Phase 1 Phase 2 | Terminated(slow accrual) | - | United States, Florida ... more >> H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, New York New York University New York, New York, United States, 10016 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 Collapse << |
| NCT01584648 | - | - | Active, not recruiting | - | - |
| NCT01584648 | Melanoma | Phase 3 | Active, not recruiting | October 15, 2018 | - |
| NCT01750918 | Cancer | Phase 2 | Active, not recruiting | April 30, 2019 | United States, Arizona ... more >> Novartis Investigative Site Scottsdale, Arizona, United States, 85259 United States, California Novartis Investigative Site San Francisco, California, United States, 94115 United States, Massachusetts Novartis Investigative Site Boston, Massachusetts, United States, 02114 Novartis Investigative Site Boston, Massachusetts, United States, 02215 United States, New York Novartis Investigative Site New York, New York, United States, 10065 United States, North Carolina Novartis Investigative Site Chapel Hill, North Carolina, United States, 27599 United States, Pennsylvania Novartis Investigative Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Novartis Investigative Site Nashville, Tennessee, United States, 37203 Belgium Novartis Investigative Site Bruxelles, Belgium, 1200 Novartis Investigative Site Leuven, Belgium, 3000 France Novartis Investigative Site Paris cedex 12, France, 75571 Novartis Investigative Site Villejuif Cedex, France, 94805 Italy Novartis Investigative Site Milano, Lombardia, Italy, 20162 Novartis Investigative Site Candiolo (TO), Piemonte, Italy, 10060 Japan Novartis Investigative Site Aichi, Japan, 464-8681 Novartis Investigative Site Chiba, Japan, 277-8577 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1066 CX Novartis Investigative Site Utrecht, Netherlands, 3584 CX Spain Novartis Investigative Site Barcelona, Spain, 08035 United Kingdom Novartis Investigative Site Birmingham, United Kingdom, B15 2TH Collapse << |
| NCT01767454 | Solid Tumours | Phase 1 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90025 GSK Investigational Site San Francisco, California, United States, 94115 United States, Massachusetts GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, Missouri GSK Investigational Site Saint Louis, Missouri, United States, 63110 United States, New York GSK Investigational Site New York, New York, United States, 10065 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37232 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Collapse << |
| NCT01072175 | Cancer | Phase 2 | Completed | - | United States, California ... more >> Novartis Investigative Site Los Angeles, California, United States, 90025 Novartis Investigative Site San Francisco, California, United States, 94115 United States, Colorado Novartis Investigative Site Aurora, Colorado, United States, 80045 United States, Connecticut Novartis Investigative Site New Haven, Connecticut, United States, 06520 United States, Florida Novartis Investigative Site Tampa, Florida, United States, 33612 United States, Maryland Novartis Investigative Site Lutherville-Timonium, Maryland, United States, 21093 United States, Massachusetts Novartis Investigative Site Boston, Massachusetts, United States, 02114 Novartis Investigative Site Boston, Massachusetts, United States, 02215 United States, Minnesota Novartis Investigative Site Rochester, Minnesota, United States, 55905 United States, Pennsylvania Novartis Investigative Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Novartis Investigative Site Nashville, Tennessee, United States, 37203 Novartis Investigative Site Nashville, Tennessee, United States, 37232 United States, Texas Novartis Investigative Site Houston, Texas, United States, 77030-4009 Australia, New South Wales Novartis Investigative Site Westmead, New South Wales, Australia, 2145 Australia, Victoria Novartis Investigative Site Heidelberg, Victoria, Australia, 3084 Collapse << |
| NCT01878396 | - | - | Unknown | December 2017 | Italy ... more >> Vanna Chiarion-Sileni, MD Recruiting Padova, PD, Italy, 35128 Contact: Vanna Chiarion-Sileni, MD 0039 0498215931 mgaliz@tiscali.it Collapse << |
| NCT01943422 | Melanoma | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Collapse << |
| NCT00880321 | Cancer | Phase 1 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90025 United States, New York GSK Investigational Site New York, New York, United States, 10016 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Australia, New South Wales GSK Investigational Site Randwick, New South Wales, Australia, 2031 GSK Investigational Site Westmead, New South Wales, Australia, 2145 Australia, South Australia GSK Investigational Site Adelaide, South Australia, Australia, 5000 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 Collapse << |
| NCT02143999 | - | - | Completed | - | Italy ... more >> Policlinico Ospedaliero Ss Annunziata; U.O. Di Clinica Oncologica Chieti, Abruzzo, Italy, 66100 IRCCS IST. Tumori Fondaz. Pascale; S.C. Oncologia Medica,Melanoma,Immunoterapia E Terapie Innovative Napoli, Campania, Italy, 80131 Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica Bologna, Emilia-Romagna, Italy, 40138 Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST);U.O. di Immunoterapia Meldola, Emilia-Romagna, Italy, 47014 Arcispedale Santa Maria Nuova; Oncologia Reggio Emilia, Emilia-Romagna, Italy, 42100 Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica Roma, Lazio, Italy, 00128 Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche Roma, Lazio, Italy, 00161 IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A Genova, Liguria, Italy, 16132 Asst Papa Giovanni XXIII; Oncologia Medica Bergamo, Lombardia, Italy, 24128 Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina Brescia, Lombardia, Italy, 25123 Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2 Milano, Lombardia, Italy, 20133 Irccs Istituto Europeo Di Oncologia (Ieo); Unita' Di Ricerca Traslazionale Del Melanoma Milano, Lombardia, Italy, 20141 Fondazione Del Piemonte Per L'oncologia IRCC Di Candiolo Candiolo, Piemonte, Italy, 10060 Azienda Sanitaria Ospedaliera s. Croce e Carle; Oncologia Medica Cuneo, Piemonte, Italy, 12100 Ospedale Maggiore Della Carita; Oncologia Medica Novara, Piemonte, Italy, 28100 Azienda Ospedaliera Città della Salute e della Scienza di Torino Torino, Piemonte, Italy, 10126 Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Puglia, Italy, 70124 Policlinico P. Giaccone; Istituto Di Oncologia, Clinica Medica 1 Palermo, Sicilia, Italy, 90127 Ospedale S. Vincenzo; Oncologia Medica Taormina, Sicilia, Italy, 98030 Azienda Sanitaria di Firenze Presidio Palagi - SC Dermatologia II e Fisioterapia Dermatologica Firenze, Toscana, Italy, 50125 Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2 Pisa, Toscana, Italy, 56100 Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica Siena, Toscana, Italy, 53100 Azienda Ospedaliero Universitaria di Ferrara - U.O. Di Oncologia Cona (FE), Veneto, Italy, 44124 Azienda Ospedaliera di Verona-Policlinico G.B. Rossi; Oncologia Medica Verona, Veneto, Italy, 37134 Collapse << |
| NCT01597908 | Melanoma | Phase 3 | Active, not recruiting | March 18, 2019 | - |
| NCT02314143 | Melanoma | Phase 2 | Completed | - | France ... more >> GSK Investigational Site Bordeaux, France, 33075 GSK Investigational Site Marseille cedex 5, France, 13385 GSK Investigational Site Reims Cedex, France, 51092 GSK Investigational Site Rennes Cedex, France, 35042 GSK Investigational Site Villejuif cedex, France, 94805 Spain GSK Investigational Site Barcelona, Spain, 08036 GSK Investigational Site Madrid, Spain, 28041 Collapse << |
| NCT01603212 | Melanoma | Phase 1 Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01894672 | Melanoma | Phase 2 | Completed | - | United States, New Jersey ... more >> Memorial Sloan Kettering Cancer Center at Basking Ridge Basking Ridge, New Jersey, United States United States, New York Memorial Sloan Kettering Cancer Center at Commack Commack, New York, United States, 11725 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Memorial Sloan Kettering Cancer Center at Mercy Medical Center Rockville Centre, New York, United States, 11570 Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center Sleepy Hollow, New York, United States, 10591 Collapse << |
| NCT01711632 | Hairy Cell Leukemia | Phase 2 | Active, not recruiting | October 2019 | United States, California ... more >> Scripps Clinic La Jolla, California, United States, 92037 United States, Illinois Northwestern University Evanston, Illinois, United States, 60208 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
| NCT01597908 | - | - | Active, not recruiting | - | - |
| NCT01894672 | - | - | Completed | - | - |
| NCT02145143 | Thyroid Carcinoma | Not Applicable | Active, not recruiting | May 2019 | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT02038348 | Metastatic Melanoma | Phase 2 | Unknown | June 2016 | France ... more >> Assistance Publique Hopitaux de Marseille Recruiting Marseille, France, 13354 Contact: caroline gaudy caroline.gaudy@ap-hm.fr Principal Investigator: caroline gaudy Collapse << |
| NCT01619774 | Melanoma | Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01072175 | - | - | Completed | - | - |
| NCT03410875 | Hairy Cell Leukemia ... more >> Leukemia Leukemia, Hairy Cell Collapse << | Phase 2 | Recruiting | January 2020 | United States, Connecticut ... more >> Yale University Not yet recruiting New Haven, Connecticut, United States, 06511 Contact: Gottfried von Keudell, MD/PhD 203-737-5312 United States, Massachusetts Dana Farber Cancer Institute Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Eric Winer, MD 617-632-6876 United States, New York Memorial Sloan - Kettering Cancer Center Recruiting New York, New York, United States, 10021 Contact: Jae Park, MD 212-639-4048 parkj6@mskcc.org Collapse << |
| NCT01619774 | - | - | Completed | - | - |
| NCT02089724 | - | - | Recruiting | April 2019 | United States, New York ... more >> Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eli L. Diamond, MD, PhD diamonel@mskcc.org Principal Investigator: Eli L. Diamond, MD, PhD Sub-Investigator: Omar Abdel-Wahab, MD France AP-HP, Groupe Hospitalier Pitié-Salpêtrière Recruiting Paris, France, 75013 Contact: Julien Haroche, MD, PhD +33 1 42 17 80 37 julien.haroche@psl.aphp.fr Contact: Fleur Cohen Aubart, MD, PhD +33 1 42 17 82 42 fleur.cohen@psl.aphp.fr Principal Investigator: Julien Haroche, MD, PhD Sub-Investigator: Fleur Cohen Aubart, MD, PhD Sub-Investigator: Zahir Amoura, MD, MSc Collapse << |
| NCT02296996 | Malignant Melanoma | Phase 2 | Active, not recruiting | December 2017 | Belgium ... more >> UZ Brussel Brussels, Belgium, 1090 Collapse << |
| NCT01037127 | Cancer | Phase 2 | Completed | - | United States, California ... more >> GSK Investigational Site Los Angeles, California, United States, 90024 United States, Colorado GSK Investigational Site Aurora, Colorado, United States, 80045 United States, New York GSK Investigational Site New York, New York, United States, 10016 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 GSK Investigational Site Nashville, Tennessee, United States, 37232-6307 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030-4009 Australia, New South Wales GSK Investigational Site Westmead, New South Wales, Australia, 2145 Australia, Victoria GSK Investigational Site East Melbourne, Victoria, Australia, 3002 Australia, Western Australia GSK Investigational Site Nedlands, Western Australia, Australia, 6009 Collapse << |
| NCT01841463 | Advanced or Inoperable Maligna... more >>nt Melanoma With BRAF Mutation Collapse << | Phase 1 | Suspended(Sponsor decision not... more >> related to patient safety) Collapse << | March 2016 | United States, California ... more >> UCSF Medical Center at Mount Zion South San Francisco, California, United States, 94115 United States, Colorado University of Colorado Anschutz Medical Campus Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown-Lombardi Comprehensive Cancer Ctr Washington, District of Columbia, United States, 20057 United States, Texas The University of Texas, MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01726738 | Stage III Melanoma ... more >> Stage IV Melanoma Unresectable Melanoma BRAF Mutant Melanoma Collapse << | Phase 2 | Completed | - | United States, North Carolina ... more >> Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, North Carolina, United States, 27599 Collapse << |
| NCT01037127 | - | - | Completed | - | - |
