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CAS No.: 1227633-49-9

StemRegenin 1 Catalog No. CSN16930

Synonyms: SR1

StemRegenin 1 is an AhR antagonist with IC50 of 127 nM. Also, it stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin ^[3]. StemRegenin 1 (SR1) is a potent aryl hydrocarbon receptor (AHR) antagonist with IC₅₀ of 127 nM. Culture of hematopoietic stem cells (HSCs) with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice, resulting from antagonizing the AHR ^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02765997	Acute Myeloid Leukemia ... more >> Acute Lymphocytic Leukemia Chronic Myelogenous Leukemia Myelodysplasia Collapse <<	Phase 2	Withdrawn(IRB Disapproval)	June 2022	United States, Minnesota ... more >> University of Minnesota Cancer Center Minneapolis, Minnesota, United States, 55455 Collapse <<

参考文献

[1] Gori JL, Chandrasekaran D, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012 Sep 27;120(13):e35-44.
[2] Boitano AE, Wang J, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8.
[3] Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. doi: 10.1073/pnas.232562899. Epub 2002 Oct 30. PMID: 12409613; PMCID: PMC137481.
[4] Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664. PMID: 20688981; PMCID: PMC3033342.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3281 mL
- 11.6404 mL
- 23.2809 mL
- 5 mM
- 0.4656 mL
- 2.3281 mL
- 4.6562 mL
- 10 mM
- 0.2328 mL
- 1.1640 mL
- 2.3281 mL

技术信息

CAS号

1227633-49-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H23N5OS

运输

蓝冰

分子量

429.54

别名

SR1

溶解度

DMSO	86.0 mg/mL (200.2 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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