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CAS No.: 24276-84-4

Sodium ferulic/阿魏酸钠 Catalog No. CSN11008

Synonyms: Coniferic acid sodium;Ferulic Acid Sodium;阿魏酸钠

Sodium ferulate is the sodium salt of ferulic acid which is used for the treatment of cardiovascular disease.

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描述G protein-coupled receptor (GPCR) agonists through their receptors can transactivate protein tyrosine kinase receptors such as epidermal growth factor receptor and serine/threonine kinase receptors most notably transforming growth factor (TGF)-β receptor (TβRI). Several GPCR agonists such as Ang II, thrombin, ET‐1 can mediate the transactivation of a multitude of protein tyrosine kinase receptors^[3]. Sodium ferulate (SF), a sodium salt of ferulic acid (3-methoxy-4-hydroxy-cinnamate sodium), acts as a potent antioxidant by scavenging ROS and enhancing the cell stress response through the upregulation of cytoprotective systems, such as heme oxygenase-1, superoxide dismutase, catalase, and Hsp70^[4]. SF inhibits the expression and/or activity of enzymes, including inducible nitric oxide synthase, caspases, and cyclooxygenase-2, as well as the activation of JNK. In a vitro study, with treatments of 250, 500 and 1,000 μmol/l SF, the apoptotic percentage of OA chondrocytes was attenuated in a concentration-dependent manner^[5]. The MCF-7 cells were treated with ferulic acid at 1 µM, 10 µM and 100 µM along with 100 ng EGF/ml from 24 to 96 h. Ferulic acid gave 14 to 30% inhibition from 24 to 96 h at 10 µM and 20 to 35% inhibition from 24 to 96 h at 100 µM^[6]. In a vivo experiment, oral administration of taurine and SF (40 and 30 mg/kg/day, respectively) significantly attenuated the developed liver damage induced by administration of iron, resulting in decreases of liver weight/body weight and serum ALT and AST levels^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03092076	Healthy	Phase 1	Completed	-	-
NCT01982734	Pharmacokinetics of New Curcum... more >>in Formulations Safety of New Curcumin Formulations Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT02150356	Glucose and Lipid Metabolism ... more >> Incretin Hormones Plasma Levels Inflammation, Oxidative Stress and Endothelial Function Collapse <<	Not Applicable	Completed	-	Italy ... more >> Dept. Clinical Medicine and Surgery, Federico II University Naples, Italy, 80131 Collapse <<

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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.6261 mL
- 23.1304 mL
- 46.2608 mL
- 5 mM
- 0.9252 mL
- 4.6261 mL
- 9.2522 mL
- 10 mM
- 0.4626 mL
- 2.3130 mL
- 4.6261 mL

技术信息

CAS号

24276-84-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H9NaO4

运输

蓝冰

分子量

216.17

别名

Coniferic acid sodium;Ferulic Acid Sodium;阿魏酸钠

溶解度

DMSO	2.0 mg/mL (9.3 mM)
Ethanol	Insoluble

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