|3-(3,4-二羟苯基)-2-羟基丙酸钠|CsnPharm

CAS No.: 67920-52-9

丹参素钠 Catalog No. CSN16467

Synonyms: Danshensu Sodium Salt;Danshensu sodium;丹参素钠

Sodium danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.

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技术信息

生物活性

描述Sodium Danshensu is odium salt of danshensu from the widely used Chinese herb Danshen. In thoracic arteries under basal tonus, sodium danshensu (0.3-3 g/L) produced a dose-dependent transient contraction. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produced a weak contraction, while high concentrations (1-3 g/L) produced a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu inhibited phenylephrine- and CaCl(2)-induced vasoconstriction in Ca(2+)-free medium^[3]. Sodium danshensu (SDS, 700 mg/kg) was administered intraperitoneally (i.p.) 10 min after stroke and once daily until animals were sacrificed. At 14 days after stroke, SDS significantly increased the expression of vascular endothelial growth factor (VEGF), stromal-derived factor-1 (SDF-1), brain-derived neurotrophic factor (BDNF), and endothelial nitric oxide synthase (eNOS) in the peri-infarct region. SDS-treated animals showed increased number of doublecortin (DCX)-positive cells^[4]. Treatment with SDSS (Sodium Danshensu) for 5 days after MCAO (middle cerebral artery occlusion) remarkably improved neurologic deficits and survival rate, reduced infarct volume and the number of dead neurons. SDSS also decreased the number of apoptotic cells, regulated the expression of Bcl-2 and Bax, and increased the ratio of Bcl-2/Bax^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5423 mL
- 22.7113 mL
- 45.4226 mL
- 5 mM
- 0.9085 mL
- 4.5423 mL
- 9.0845 mL
- 10 mM
- 0.4542 mL
- 2.2711 mL
- 4.5423 mL

技术信息

CAS号

67920-52-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H9NaO5

运输

蓝冰

分子量

220.15

别名

Danshensu Sodium Salt;Danshensu sodium;丹参素钠

溶解度

DMSO	7.0 mg/mL (31.8 mM) warming
Water	22.0 mg/mL (99.9 mM)
Ethanol	Insoluble

动物实验配方

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