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CAS No.: 55-06-1

三碘代甲状腺素钠盐 Catalog No. CSN10110

Synonyms: 三碘代甲状腺素钠盐;Triiodothyronine sodium;3,3',5-Triiodo-L-thyronine sodium

Liothyronin Sodium a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine, used to treat hypothyroidism.

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技术信息

生物活性

描述Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine (Sodium) is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed^[3]. High T(3) (triiodothyronine) levels induce a low TRalpha1:TRalpha2 ratio which could protect the cell from excessive T(3)-induced gene expression^[4]. Expression of a mutant receptor with impaired triiodothyronine (T(3)) binding and dominant negative activity affected cerebellar development and motor performance. TRs are also involved in adult brain function. TRalpha1 deletion, or expression of a dominant negative mutant receptor, induces consistent behavioral changes in adult mice, leading to severe anxiety and morphological changes in the hippocampus^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4860 mL
- 7.4299 mL
- 14.8597 mL
- 5 mM
- 0.2972 mL
- 1.4860 mL
- 2.9719 mL
- 10 mM
- 0.1486 mL
- 0.7430 mL
- 1.4860 mL

技术信息

CAS号

55-06-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H11I3NNaO4

运输

蓝冰

分子量

672.96

别名

三碘代甲状腺素钠盐;Triiodothyronine sodium;3,3',5-Triiodo-L-thyronine sodium;T3 sodium;碘塞罗宁钠

溶解度

DMSO	99.0 mg/mL (147.1 mM)
Water	Insoluble
Ethanol	Insoluble

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