|2-(4-乙基苯氧基)-N-(4-氟-3-硝基苯基)乙酰胺|CsnPharm

CAS No.: 425613-09-8

SJ000291942 Catalog No. CSN22506

Synonyms: SJ000291942

SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.

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400-920-2911

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实验方案

技术信息

生物活性

描述The bone morphogenetic proteins (BMP) are secreted signaling molecules that belong to the transforming growth factor beta family. They are involved in a variety of biological processes, including tissue homeostasis, bone development, embryonic patterning and development, and stem cell differentiation. SJ000291942 is an activator of the BMP signaling pathway. SJ000291942 at a concentration of 1 - 50μM caused ventralization of zebrafish embryos, which was consistent with increased BMP signaling activity. It also upregulated the BMP target genes bone morphogenetic protein 2b and sizzled and the cooperatively-induced BMP target genes vent and vox. SJ000291942 induced p-SMAD1/5/8 maximally in human cervical carcinoma clonal reporter cell line C33A-2D2 at 1h of treatment. Also in C33A-2D2 cells, treatment with SJ000291942 induced the phosphorylated extracellular signal-regulated protein kinase, ERK1/2 (P-ERK1/2). BMP4 treatment at high doses (100 and 300ng) generated a gene expression signature that was similar to osteoblast expression, while BMP4 administration at a low dose (10ng) aligned closely with 25μM SJ000291942^[1].
参考文献

[1] Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein D, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol. 2017 Sep 15;12(9):2436-2447. doi: 10.1021/acschembio.7b00527

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1417 mL
- 15.7085 mL
- 31.4169 mL
- 5 mM
- 0.6283 mL
- 3.1417 mL
- 6.2834 mL
- 10 mM
- 0.3142 mL
- 1.5708 mL
- 3.1417 mL

技术信息

CAS号

425613-09-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H15FN2O4

运输

蓝冰

分子量

318.30

别名

SJ000291942

溶解度

DMSO	64.0 mg/mL (201.1 mM)
Water	Insoluble
Ethanol	12.0 mg/mL (37.7 mM)

动物实验配方

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