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CAS No.: 5610-40-2

Securinine/一叶萩碱 Catalog No. CSN11911

Synonyms: (–)-Securinine;NSC 107413;L-Securinine

Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).

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400-920-2911

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技术信息

生物活性

描述Securinine induces apoptosis and activates cell cycle checkpoints in HeLa cells which is associated with oxidative stress. Securinine was significantly potent on HeLa cells growth inhibition with IC50 values of 7.02 ± 0.52 μg/ml (32.3 μM). The most active securinine induced apoptosis in a dose-dependent manner in the tested cells, increased the percentage of ROS (reactive oxygen species) positive cells and depolarized cells as well as stimulated the activity of ERK1/2, caspase-9 and -3/7. Securinine also induced cell cycle arrest in S phase^[3]. Securinine is a plant-derived alkaloid used clinically as a therapeutic for primarily neurological related diseases. Securinine induces monocytic differentiation of a wide range of myeloid leukemia cell lines as well as primary leukemic patient samples^[4]. When treated SMA (Spinal muscular atrophy)-like mice with securinine by i.p. injection, securinine treatment increased SMN2 exon 7 inclusion and SMN protein expression in the brain and spinal cord^[5]. Aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.6027 mL
- 23.0135 mL
- 46.0270 mL
- 5 mM
- 0.9205 mL
- 4.6027 mL
- 9.2054 mL
- 10 mM
- 0.4603 mL
- 2.3014 mL
- 4.6027 mL

技术信息

CAS号

5610-40-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H15NO2

运输

蓝冰

分子量

217.26

别名

(–)-Securinine;NSC 107413;L-Securinine;一叶秋碱;一叶萩碱

溶解度

DMSO	44.0 mg/mL (202.5 mM)

动物实验配方

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