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CAS No.: 1035979-44-2

Sarecycline HCl Catalog No. CSN20653

Synonyms: P005672 (hydrochloride);Sarecycline;WC 3035

Sarecycline HCl is a tetracycline-derived narrow-spectrum antibiotic for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris.

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描述Sarecycline hydrochloride (Seysara) is a novel, narrow-spectrum tetracycline derivative for the treatment of inflammatory non-nodular moderate to severe acne vulgaris. Sarecycline exhibits antibacterial activity against important skin/soft tissue pathogens with targeted activity against Cutibacterium acnes--an anaerobic Gram-positive bacterium linked with acne lesions--and also exerts anti-inflammatory effects as do other tetracyclines used in the treatment of acne vulgaris. Sarecycline is less potent against aerobic Gram-negative bacilli and anaerobic bacteria associated with endogenous intestinal microbial flora^[2]. The narrow-spectrum antibiotic sarecycline was safe, well tolerated, and effective for moderate to severe acne, with low rates of side effects common with tetracycline antibiotics^[3]. The 1.5-mg/kg sarecycline dose have efficacy in reducing inflammatory lesions, is well tolerated, and has more targeted antimicrobial activity, which may help reduce the risk of developing antibiotic resistance^[4].
参考文献

[1] Karpiuk I, Tyski S. Looking for new preparations for antibacterial therapy. IV. New antimicrobial agents from the aminoglycoside, macrolide and tetracycline groups in clinical trials. Przegl Epidemiol. 2015;69(4):723-9, 865-70.
[2] Kaul G, Saxena D, Dasgupta A, Chopra S. Sarecycline hydrochloride for the treatment of acne vulgaris. Drugs Today (Barc). 2019;55(10):615–625
[3] Moore A, Green LJ, Bruce S, et al. Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials. J Drugs Dermatol. 2018;17(9):987–996
[4] Haidari W, Bruinsma R, Cardenas-de la Garza JA, Feldman SR. Sarecycline Review. Ann Pharmacother. 2020;54(2):164–170

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9085 mL
- 9.5427 mL
- 19.0853 mL
- 5 mM
- 0.3817 mL
- 1.9085 mL
- 3.8171 mL
- 10 mM
- 0.1909 mL
- 0.9543 mL
- 1.9085 mL

技术信息

CAS号	1035979-44-2	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C24H30ClN3O8	运输	蓝冰
分子量	523.96	别名	P005672 (hydrochloride);Sarecycline;WC 3035;P005672 HCl;P-005672;Seysara

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