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CAS No.: 149709-62-6
Synonyms: AHU-377;沙库必曲
AHU-377 and valsartan can compose LCZ696 in a 1:1 molar ratio. It also works as an inhibitor of neprilysin with IC50 value of 5 nM.
生物活性
靶点 | Neprilysin IC50:5.0nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01601470 | Mild to Moderate Hypertension | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Berlin, Germany, 14050 Collapse << |
NCT01569815 | Mild and Moderate Renal Impair... more >>ment Collapse << | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Neuss, Germany, 41460 Russian Federation Novartis Investigative Site Moscow, Russian Federation, 117292 Serbia Novartis Investigative Site Belgrade, Serbia Collapse << |
NCT01621633 | Hepatic Impairment | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Grunstadt, Germany, D-67269 Collapse << |
实验方案
技术信息
CAS号 | 149709-62-6 | 储存条件 |
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分子式 | C24H29NO5 | 运输 | 蓝冰 | |
分子量 | 411.49 | 别名 | AHU-377;沙库必曲 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01601470 | Mild to Moderate Hypertension | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Berlin, Germany, 14050 Collapse << |
NCT01569815 | Mild and Moderate Renal Impair... more >>ment Collapse << | Phase 1 | Completed | - | Germany ... more >> Novartis Investigative Site Neuss, Germany, 41460 Russian Federation Novartis Investigative Site Moscow, Russian Federation, 117292 Serbia Novartis Investigative Site Belgrade, Serbia Collapse << |
NCT01621633 | Hepatic Impairment | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Grunstadt, Germany, D-67269 Collapse << |
NCT01569815 | - | - | Completed | - | - |
NCT01601470 | - | - | Completed | - | - |
NCT00549770 | Hypertension | Phase 2 | Completed | - | - |
NCT01281306 | Systolic Hypertension | Phase 2 | Completed | - | - |
NCT00549770 | - | - | Completed | - | - |
NCT01621633 | - | - | Completed | - | - |
NCT01281306 | - | - | Completed | - | - |
靶点 | Description | IC50 |
---|---|---|
Neprilysin | IC50:5.0nM |
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