CAS No.: 129101-54-8
Rivastigmine tartrate/酒石酸卡巴拉汀 Catalog No. CSN11852
Synonyms: ENA 713;SDZ-ENA 713;ENA 713 Tartrate
Rivastigmine tartrate is an AchR inhibitor use for treatment of mild to moderate Alzheimer's disease and Parkinson's disease with elimination half-life of 1.5 hours.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 AChE
IC50:4.15µMBuChE
IC50:37nM- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00291421 - - Completed - - NCT01401582 Dementia Not Applicable Active, not recruiting March 2018 Germany ... more >> Institute for Community Medicine Greifswald, Mecklenburg- Western Pommerania, Germany, 17489 Collapse << NCT01401582 - - Active, not recruiting - - - 更多
- 参考文献
- [1] Nieto RA, Deardorff WJ, Grossberg GT. Efficacy of rivastigmine tartrate, transdermal system, in Alzheimer's disease. Expert Opin Pharmacother. 2016;17(6):861-70.
- [2] Han HJ, Lee JJ, et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7(3):137-42.
- [3] Kandiah N, Pai MC, Senanarong V, Looi I, Ampil E, Park KW, Karanam AK, Christopher S. Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia. Clin Interv Aging. 2017 Apr 18;12:697-707. doi: 10.2147/CIA.S129145. PMID: 28458525; PMCID: PMC5402908.
- [4] Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther. 1998 Jul-Aug;20(4):634-47. doi: 10.1016/s0149-2918(98)80127-6. PMID: 9737824.
- [5] Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 Feb 3;10(1):47. doi: 10.1038/s41398-020-0709-x. Erratum in: Transl Psychiatry. 2020 Mar 2;10(1):81. PMID: 32066688; PMCID: PMC7026402.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 129101-54-8 | 储存条件 |
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| 分子式 | C18H28N2O8 | 运输 | 蓝冰 | |||||
| 分子量 | 400.42 | 别名 | ENA 713;SDZ-ENA 713;ENA 713 Tartrate;SDZ-ENA-713 Tartrate;Rivastigmine (tartrate);Exelon;Rivastigmine Tartrate;Rivastigmine bitartrate;酒石酸卡巴拉汀 | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00291421 | - | - | Completed | - | - |
| NCT01401582 | Dementia | Not Applicable | Active, not recruiting | March 2018 | Germany ... more >> Institute for Community Medicine Greifswald, Mecklenburg- Western Pommerania, Germany, 17489 Collapse << |
| NCT01401582 | - | - | Active, not recruiting | - | - |
| NCT02623764 | - | - | Active, not recruiting | November 2019 | - |
| NCT01852110 | - | - | Terminated(Stage 1 interim ana... more >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) Collapse << | - | - |
| NCT01696591 | - | - | Unknown | September 2013 | Korea, Republic of ... more >> Samsung Medical Center Recruiting Seoul, Korea, Republic of, 135-710 Contact: Duk L. Na, MD, PhD +82-2-3410-3594 dukna@naver.com Collapse << |
| NCT02374567 | Dementia Depr... more >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Collapse << | Phase 3 | Terminated | - | Germany ... more >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Collapse << |
| NCT02860338 | - | - | Completed | - | - |
| NCT03565809 | - | - | Enrolling by invitation | December 2018 | France ... more >> University Hospital Toulouse, France, 31000 Collapse << |
| NCT01023425 | Alzheimer's Disease ... more >> Dementia Collapse << | Not Applicable | Completed | - | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Collapse << |
| NCT00880412 | Alzheimer's Disease | Phase 2 | Completed | - | France ... more >> Hôpital Privé Les Magnolias Ballainvilliers, France, 91160 Cabinet Médical Bergerac, France, 24100 Fleyriat Hospital Bourg en Bresse, France, 01012 Cabinet Médical Dijon, France, 21000 Charles Foix Hospital Ivry sur Seine, France, 94026 Cabinet Médical La Seyne sur Mer, France, 83500 Roger Salengro Hospital Lille, France, 59037 Dupuytren Hospital Limoges, France, 87042 Clinique Léopold Bellan Magnanville, France, 78200 Cabinet Médical Montpellier, France, 34070 Cabinet Médical 2 Montpellier, France, 34080 CHU Nantes Hôpital Laennec Nantes, France, 44093 Cabinet Médical 2 Nice, France, 06000 Cabinet Médical Nice, France, 06000 CHU Cochin Broca Paris, France, 75013 Cabinet Médical Rambouillet, France, 78120 CHU Rennes Rennes, France, 35033 Cabinet Médical Rodez, France, 12000 Cabinet Médical Rueil Malmaison, France, 92500 Cabinet Médical Saint Brieuc, France, 22000 Cabinet Médical Toulon, France, 83000 Purpan-Casselardit Hospital - University of Toulouse Toulouse, France, 31059 Collapse << |
| NCT01852110 | Alzheimer's Disease | Phase 2 | Terminated(Stage 1 interim ana... more >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) Collapse << | - | - |
| NCT01951118 | Alzheimer Disease ... more >> Mild Cognitive Impairment Delirium, Dementia, Amnestic, Cognitive Disorders Collapse << | Phase 4 | Active, not recruiting | May 2019 | United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse << |
| NCT02438202 | Alzheimer's Disease | Not Applicable | Not yet recruiting | January 2021 | - |
| NCT00348140 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT00393432 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT03025334 | Parkinson Disease ... more >> Mild Cognitive Impairment Collapse << | Not Applicable | Recruiting | December 2020 | Canada, Manitoba ... more >> University of Manitoba Recruiting Winnipeg, Manitoba, Canada, R3E 0J9 Contact: Ji Hyun Ko, PhD 204-318-2566 ji.ko@umanitoba.ca Collapse << |
| NCT01554475 | - | - | Completed | - | Norway ... more >> Kløveråsen Bodø, Norway, N-8076 Collapse << |
| NCT02670161 | Brain Tumors ... more >>Epilepsy Migraine Mild Cognitive Impairment Concussion Multiple Sclerosis Neuropathy Parkinson's Restless Legs Syndrome Stroke Collapse << | Phase 4 | Enrolling by invitation | April 2020 | - |
| NCT03250741 | Alzheimer Disease | Phase 2 | Recruiting | June 2018 | Italy ... more >> Santa Lucia Foundation Recruiting Rome, Italy, 00179 Contact: Sonia Bonnì Collapse << |
| NCT00105105 | Alzheimer's Disease | Phase 2 | Terminated | - | United States, Arizona ... more >> Pivotal Research Center Mesa, Arizona, United States, 85210 Pivotal Research Center Peoria, Arizona, United States, 85381 United States, California ATP Clinical Trials Fountain Valley, California, United States, 92708 UCI Irvine Medical Center Orange, California, United States, 92868 California Neuroscience Research Medical Group, Inc. Sherman Oaks, California, United States, 91403 AVI Clinical Research Torrance, California, United States, 90505 United States, Florida Baumel-Eisner Neuromed Inst Boca Raton, Florida, United States, 33486 Baumel-Eisner Neuromed Inst Ft. Lauderdale, Florida, United States, 33321 Clinical Physiology Associates Ft. Myers, Florida, United States, 33916 Baumel-Eisner Neuromed Inst Miami Beach, Florida, United States, 33154 Stedman Clinical Trials Tampa, Florida, United States, 33613 Johnnie B. Byrd, Sr. Alzheimer's Center & Research Inst Tampa, Florida, United States, 33647 United States, New Jersey Memory Enhancement Center Long Branch, New Jersey, United States, 07740 United States, New York Eastside Medical Research New York, New York, United States, 10021 United States, Ohio Neuro Center of Ohio Toledo, Ohio, United States, 43623 United States, Oklahoma Pahl Pharmaceutical Research, LLC Oklahoma City, Oklahoma, United States, 73118 Clinical Pharmaceutical Trials, Inc. Tulsa, Oklahoma, United States, 74104 United States, Pennsylvania Clinical Trials Research Services Pittsburgh, Pennsylvania, United States, 15206 United States, Texas Grayline Clinical Drug Trials Wichita Falls, Texas, United States, 76309 United States, Virginia International Clinical Research Associates Richmond, Virginia, United States, 23229 International Clinical Research Associates Virginia Beach, Virginia, United States, 23452 Collapse << |
| NCT01872598 | Alzheimer Disease | Phase 3 | Active, not recruiting | October 2019 | Spain ... more >> Hospital Universitario Ramón y Cajal Madrid, Spain, 28034 Collapse << |
| NCT00348140 | - | - | Completed | - | - |
| NCT01409564 | Alzheimer's Dementia | Phase 4 | Completed | - | Korea, Republic of ... more >> SMG-SNU Boramae Medical Center Seoul, Korea, Republic of, 156-707 Collapse << |
| NCT01626391 | - | - | Terminated(This study has been... more >> terminated for administrative reasons only.) Collapse << | - | - |
| NCT00018278 | Alzheimer Disease | Phase 4 | Completed | - | United States, California ... more >> Department of Veterans Affairs San Diego, California, United States, 92161 Collapse << |
| NCT01626391 | Alzheimer's Disease | Phase 2 | Terminated(This study has been... more >> terminated for administrative reasons only.) Collapse << | - | Germany ... more >> Achim, Germany Berlin, Germany Leipzig, Germany München, Germany United Kingdom Birmingham, United Kingdom Bradford, United Kingdom Crowborough, United Kingdom Duston, United Kingdom Oxford, United Kingdom Sheffield, United Kingdom St Leonards on Sea, United Kingdom Staffordshire, United Kingdom Collapse << |
| NCT00051909 | Alzheimer's Disease | Phase 2 | Completed | - | United States, California ... more >> Beverly Hills, California, United States Fresno, California, United States United States, Florida Boca Raton, Florida, United States Fort Lauderdale, Florida, United States Miami Beach, Florida, United States United States, Massachusetts Boston, Massachusetts, United States United States, Oklahoma Oklahoma City, Oklahoma, United States Tulsa, Oklahoma, United States United States, Texas Wichita Falls, Texas, United States Collapse << |
| NCT02007291 | - | - | Completed | - | - |
| NCT01409564 | - | - | Completed | - | - |
| NCT00223691 | Autonomic Failure ... more >> Orthostatic Hypotension Collapse << | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
| NCT02187276 | - | - | Completed | - | - |
| NCT01677754 | Alzheimer's Disease | Phase 2 | Completed | - | - |
| NCT00766363 | Alzheimer's Disease ... more >> Central Nervous System Diseases Collapse << | Phase 1 | Completed | - | United States, California ... more >> Pacific Research Network, Inc. San Diego, California, United States, 92103 United States, Florida MD Clinical Hallandale Beach, Florida, United States, 33009 United States, New Jersey Comprehensive Clinical Research Berlin, New Jersey, United States, 08009 Global Medical Institutes, LLC Princeton, New Jersey, United States, 08540 Collapse << |
| NCT00102284 | Healthy | Phase 4 | Terminated | - | Germany ... more >> Dept. of Neurology, University Hospital Muenster Muenster, Nordrhein-Westfalen, Germany, 48129 Collapse << |
| NCT02007291 | - | - | Completed | - | - |
| NCT00551161 | - | - | Completed | - | - |
| NCT01944436 | - | - | Completed | - | Canada, Ontario ... more >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Collapse << |
| NCT03454646 | Alzheimer Disease ... more >> Cholinesterase Inhibitors Collapse << | Phase 4 | Not yet recruiting | September 15, 2021 | France ... more >> CHU d'Amiens Centre Mémoire Ressources Recherche Not yet recruiting Amiens, France, 80054 Contact: Agnès DEVENDEVILLE 03.22.66.82.40 devendeville.agnes@chu-amiens.fr CHU d'Angers Centre Mémoire Ressources Recherche Angers, France, 49933 CHU de Bastia Centre Mémoire Ressources Recherche Not yet recruiting Bastia, France, 20604 Contact: Georges RETTALI 04.95.59.18.32 georges.retali@ch-bastia.fr CHU de Besançon Centre Mémoire Ressources Recherche Besançon, France, 25030 CHU de Bordeaux - Service de Neurologie - Centre Mémoire Ressources Recherche - Not yet recruiting Bordeaux, France, 33076 Contact: Jean-François DARTIGUES 0557820116 jean-françois.dartigues@u-bordeaux.fr CHRU Cavale Blanche Service de Gériatrie Brest, France, 29200 Service de Neuropsychologie Hôpital Neurologique Pierre Wertheimer Not yet recruiting Bron, France, 69677 Contact: Hélène MOLLION 04.72.35.71.79 helene.mollion@chu-lyon.fr CHU Côte de Nacre Service de neurologie et CMRR Caen, France, 14033 CHU de Clermont Ferrand Centre Mémoire Ressources Recherche Clermont-Ferrand, France, 63000 Hôpital Pasteur Service de Neurologie Colmar, France, 68000 CHU de Dijon- CMRR Not yet recruiting Dijon, France, 21679 Contact: Yannick BEJOT 03.80.29.58.03 yannick.bejot@chu-dijon.fr Chu de Grenoble CMRR, Neurologie Not yet recruiting Grenoble, France, 38043 Contact: Olivier MOREAUD 04 76 76 57 90 omoreaud@chu-grenoble.fr Hôpital Roger Salengro CMRR Lille, France, 59037 CHU Limoges Service de neurologie et CMRR Not yet recruiting Limoges, France, 87000 Contact: Leslie CARTZ-PIVER 05.55.43.12.15 Lcp.coglim@gmail.com AP-HM Marseille, France CHU Montpellier Hôpital Gui de Chauliac CMRR Not yet recruiting Montpellier, France, 34295 Contact: Audrey GABOREAU DE LOUSTAL 04.67.33.60.29 a-gabelle@chu-montpellier.fr CHU de Nantes Clinique Neurologique Hôpital GR Laennec Not yet recruiting Nantes, France, 44093 Contact: Claire BOUTOLEAU 02.40.16.54.22 claire.boutoleaubretonniere@chu-nantes.fr Institut Claude Pompidou Centre Mémoire de Ressources et de Recherche Not yet recruiting Nice, France, 06100 Contact: Renaud David 04.92.03.47.70 claire.paquet@inserm.fr APHP Hôpital Broca Not yet recruiting Paris, France, 75013 Contact: Olivier HANON 01.44.08.35.03 olivier.hanon@brc.aphp.fr Hôpital Universitaire de la Pitié Salpêtrière Pavillon François Lhermitte Not yet recruiting Paris, France, 75013 Contact: Stéphane EPELBAUM 01.42.16.75.22 stephane.epelbaum@psl.aphp.fr APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal CMRR Not yet recruiting Paris, France, 75475 Contact: Claire PAQUET 01.40.05.49.54 claire.paquet@inserm.fr CHU La Milétrie Pôle de Gériatrie Not yet recruiting Poitiers, France, 86021 Contact: Marc PACCALIN 05.49.44.44.27 m.paccalin@chu-poitiers.fr CHU Reims Hôpital Maison Blanche Court Séjour Gériatrique Not yet recruiting Reims, France, 51092 Contact: Jean-Luc NOVELLA 03.26.78.44.10 jl.novella@chu-reims.fr CHU de Rennes - Hôpital Pontchaillou / Service de Neurologie Not yet recruiting Rennes, France, 35033 Contact: Serge BELLIARD 02.99.87.30.26 serge.belliard@chu-rennes.fr CHU de Rouen Hôpital Charles Nicolle Service Neurologie Not yet recruiting Rouen, France, 76031 Contact: David Wallon 06.08.97.29.59 david.wallon@chu-rouen.fr Chu de Saint-Etienne, CMRR Not yet recruiting Saint-Étienne, France, 42055 Contact: Isabelle ROUCH 04.77.12.73.98 isabelle.rouch@chu-st-etienne.fr Chu de Strasbourg Hôpital Ka Robertsau Pôle de Gériatrie - CMRR Not yet recruiting Strasbourg, France, 67200 Contact: Frédéric BLANC 03.88.12.86.38 frederic.blanc@chru-strasbourg.fr Centre de Recherche Clinique du Gérontopôle Cité de la Santé Toulouse, France CHRU de Bretonneau Unité de gérontopsychiatrie Not yet recruiting Tours, France, 37000 Contact: Thomas DESMIDT 06.68.07.97.06 t.desmidt@chu-tours.fr CHU Nancy Service de Gériatrie-CMRR Not yet recruiting Vandoeuvre les nancy, France, 54511 Contact: Thérèse RIVASSEAU JONVAUX 03.83.15.35.71 t.jonveaux@chu-nancy.fr Hospice Civil de Lyon Hôpital des Charpennes Not yet recruiting Villeurbanne, France, 69100 Contact: Pierre KROLAK SALMON 04.72.43.20.50 pierre.krolak-salmon@chu-lyon.fr Collapse << |
| NCT01696123 | Alzheimer Disease | Phase 2 | Completed | - | Iran, Islamic Republic of ... more >> Loghman Hospital Tehran, Iran, Islamic Republic of, 1315693446 Collapse << |
| NCT00104442 | Alzheimer's Disease | Phase 4 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00551161 | Alzheimer Disease | Phase 4 | Completed | - | United States, New York ... more >> The Litwin-Zucker Research Center Manhasset, New York, United States, 11030 Collapse << |
| NCT01362686 | Dementia Alzh... more >>eimer's Disease Collapse << | Not Applicable | Terminated(Low study accrual c... more >>aused the study to be ended early.) Collapse << | - | United States, Indiana ... more >> Touchpoint Fishers, Indiana, United States, 46037 Methodist Center for Geriatric Medicine Indianapolis, Indiana, United States, 46202 University Clinical Neurology Indianapolis, Indiana, United States, 46202 Wishard Health Services Indianapolis, Indiana, United States, 46202 St. Vincent Center for Healthy Aging Indianapolis, Indiana, United States, 46260 Collapse << |
| NCT01362686 | - | - | Terminated(Low study accrual c... more >>aused the study to be ended early.) Collapse << | - | - |
| NCT01348282 | Neurocognitive Disturbance ... more >> HIV Infection Collapse << | Phase 4 | Completed | - | Spain ... more >> Fundació LLuita contra la SIDA Badalona, Barcelona, Spain, 08916 Collapse << |
| NCT00766363 | - | - | Completed | - | - |
| NCT01340885 | Parkinson's Disease | Phase 4 | Unknown | January 2013 | United States, Oregon ... more >> Oregon Health & Science University Recruiting Portland, Oregon, United States, 97239 Collapse << |
| NCT00102856 | Healthy | Phase 4 | Suspended | - | Germany ... more >> Dept. of Neurology, University Hospital Muenster Muenster, Nordrhein-Westfalen, Germany, 48129 Collapse << |
| NCT00219232 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT00000174 | Alzheimer Disease ... more >> Cognition Disorders Collapse << | Phase 3 | Completed | - | United States, Arizona ... more >> Medici Research Centers Peoria, Arizona, United States, 85381 United States, California University of California, Irvine Orange, California, United States, 92868 United States, Colorado University of Colorado Health Sciences Center Denver, Colorado, United States, 80220 United States, Florida Neuromedical Research Institute (Offices in Ft. Lauderdale, Miami Beach and Boca Raton) Ft. Lauderdale, Florida, United States, 33321 Miami Research Associates Miami, Florida, United States, 33176 Center for Clinical Trials and Research Venice, Florida, United States, 34285 United States, Indiana Indiana University Alzheimer's Center Indianapolis, Indiana, United States, 46202 United States, Missouri St. Louis University St. Louis, Missouri, United States, 63104 United States, New Jersey Alzheimer's Research Corporation Lakewood, New Jersey, United States, 08701 United States, New York NYU Medical Center New York, New York, United States, 10016 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Oklahoma Pahl Brain Associates, P.C. Oklahoma City, Oklahoma, United States, 73118 United States, Pennsylvania Clinical Studies, Ltd., Philadelphia Philadelphia, Pennsylvania, United States, 19106 United States, Texas St. Paul Medical Center Dallas, Texas, United States, 75235 United States, Washington University of Washington, Seattle Seattle, Washington, United States, 98108 Collapse << |
| NCT02035982 | Alzheimer's Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | Canada, Ontario ... more >> North York General Hospital Toronto, Ontario, Canada, M2K1E1 Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Collapse << |
| NCT01519271 | - | - | Completed | - | - |
| NCT01856738 | Parkinson's Disease | Phase 4 | Terminated(enrollment to slow,... more >> insufficient funds) Collapse << | - | Netherlands ... more >> Academic Medical Center Amsterdam, Netherlands, 1100 DD University Medical Center Groningen Groningen, Netherlands, 9700 RB Atrium Medical Center Heerlen, Netherlands, 6401 CX University Medical Center St Radboud Nijmegen, Netherlands, 6500 HB Collapse << |
| NCT00158210 | Substance-Related Disorders | Phase 1 | Completed | - | United States, California ... more >> University of California - Los Angeles Los Angeles, California, United States, 90024 Collapse << |
| NCT01487317 | Delirium | Phase 3 | Completed | - | France ... more >> Pitié Salpetriere Hospital Paris, France, 75013 Collapse << |
| NCT00257868 | Delirium | Phase 3 | Completed | - | Switzerland ... more >> University Hospital Basel Basel, Switzerland, 4031 Collapse << |
| NCT01519271 | Parkinson's Disease ... more >> Mild Cognitive Impairment Collapse << | Phase 4 | Completed | - | United States, Pennsylvania ... more >> University of Pennsylvania, Ralston House Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT00767091 | Parkinson's Disease ... more >> Apathy no Dementia Collapse << | Phase 3 | Completed | - | France ... more >> Devos Lille, Nord, France, 59037 Collapse << |
| NCT00669344 | Cognitive Impairment | Phase 4 | Completed | - | Singapore ... more >> Singapore General Hospital Singapore, Singapore, 169608 Collapse << |
| NCT00099242 | Alzheimer's Disease ... more >> Dementia, Alzheimer Type Collapse << | Phase 3 | Completed | - | - |
| NCT03659435 | Bioequivalence | Phase 1 | Recruiting | November 30, 2018 | Germany ... more >> SocraTec R&D GmbH, Clinical Pharmacology Unit Recruiting Erfurt, Thüringen, Germany, 99084 Contact: Cornelius Koch, MD +49-361-60205 ext 67 cornelius.koch@socratec-pharma.de Collapse << |
| NCT00234637 | Alzheimer's Disease | Phase 4 | Completed | - | France ... more >> Département de Gérontologie Clinique Limoges, Cedex, France, 87042 Collapse << |
| NCT01614886 | - | - | Completed | - | - |
| NCT00099216 | Vascular Dementia | Phase 3 | Completed | - | - |
| NCT01948791 | Alzheimer's Disease | Phase 4 | Completed | - | China ... more >> Novartis Investigative Site Beijing, China, 100053 Collapse << |
| NCT01614886 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT00549601 | Alzheimer's Disease | Phase 4 | Completed | - | Spain ... more >> Novartis Investigative Site Barcelona, Spain Collapse << |
| NCT01948791 | - | - | Completed | - | - |
| NCT00627848 | Alzheimer' Disease | Not Applicable | Completed | - | Finland ... more >> Kuopio University Hospital Kuopio, Finland, 70211 Collapse << |
| NCT03573050 | Bioequivalence | Phase 1 | Completed | - | Germany ... more >> SocraTec R&D GmbH, Clinical Pharmacology Unit Erfurt, Thüringen, Germany, 99084 Collapse << |
| NCT02839642 | Progressive Supranuclear Palsy... more >> (PSP) Collapse << | Phase 3 | Recruiting | November 2019 | France ... more >> Service de Neurologie et Pathologie du Mouvement Hôpital de La Timone Recruiting Marseille Cedex 5, France, 13385 Contact: Alexandre EUSEBIO, Dr 04.91.38.43.33 ext +33 alexandre.eusebio@ap-hm.fr Collapse << |
| NCT00599287 | Delirium | Phase 3 | Terminated(Inclusion rate too ... more >>low due to a lack of eligible patients and difficulties obtaining informed consent.) Collapse << | - | Netherlands ... more >> University Medical Center Utrecht, Netherlands, 3508 GA Collapse << |
| NCT00219245 | Traumatic Brain Injury With Pe... more >>rsistent Cognitive Deficits Collapse << | Phase 4 | Completed | - | - |
| NCT00506415 | Alzheimer Disease | Phase 3 | Completed | - | - |
| NCT00506415 | - | - | Completed | - | - |
| NCT00134953 | Cognitive Symptoms | Phase 3 | Terminated(The Principal Inves... more >>tigator left the clinic and there was no one who could take over this study.) Collapse << | - | - |
| NCT00522015 | Progressive Supranuclear Palsy... more >> Dementia Collapse << | Phase 2 | Unknown | - | Germany ... more >> University of Tuebingen Recruiting Tuebingen, Baden Wuerttemberg, Germany, 72076 Contact: Daniela Berg, Doctor +49 7071 29 80438 daniela.berg@uni-tuebingen.de Collapse << |
| NCT01047579 | Alzheimer's Disease | Phase 4 | Completed | - | Israel ... more >> Novartis Investigative Site Ashkelon, Israel Novartis Investigational Site Haifa, Israel Novartis Investigative Site Holon, Israel Novartis Investigative Site Ramat Gan, Israel Novartis Investigative Site Tel Aviv, Israel Collapse << |
| NCT00305903 | Alzheimer's Disease | Phase 4 | Completed | - | United States, New Jersey ... more >> Manchester, New Jersey, United States, 08759 Collapse << |
| NCT00130338 | Vascular Dementia | Phase 3 | Completed | - | - |
| NCT01602198 | Mild Cognitive Disorder ... more >> Mild Cognitive Impairment Collapse << | Not Applicable | Terminated(Study revised to us... more >>e a different study medication and patient population.) Collapse << | - | United States, Ohio ... more >> Cleveland Clinic Cleveland, Ohio, United States, 44195 Collapse << |
| NCT00549601 | - | - | Completed | - | - |
| NCT00988117 | Parkinsons Disease With Dement... more >>ia Parkinsons Disease With Mild to Moderate Memory and/or Thinking Problems Collapse << | Phase 4 | Completed | - | United States, California ... more >> UCalifornia SF San Francisco, California, United States, 94117 Collapse << |
| NCT00988117 | - | - | Completed | - | - |
| NCT00881205 | Multiple Sclerosis ... more >> Cognitive Impairment Collapse << | Phase 4 | Terminated(Termination of stud... more >>y due to low enrollment) Collapse << | - | - |
| NCT00881205 | - | - | Terminated(Termination of stud... more >>y due to low enrollment) Collapse << | - | - |
| NCT00731224 | Alzheimer's Disease | Phase 4 | Completed | - | - |
| NCT01399125 | Alzheimer's Disease | Phase 3 | Completed | - | China, Fujian ... more >> Novartis Investigative Site Fuzhou, Fujian, China China, Hubei Novartis Investigative Site Wuhan, Hubei, China, 430022 Novartis Investigative Site Wuhan, Hubei, China, 430030 China, Jiangsu Novartis Investigative Site Nanjing, Jiangsu, China, 210029 Novartis Investigative Site Suzhou, Jiangsu, China, 215004 China, Jilin Novartis Investigative Site Changchun, Jilin, China, 130021 China, Shanghai Novartis Investigative Site Shanghai, Shanghai, China, 200080 China, Shanxi Novartis Investigative Site Xi'an, Shanxi, China, 710032 China, Sichuan Novartis Investigative Site Chengdu, Sichuan, China, 610041 China, Zhejiang Novartis Investigative Site Hangzhou, Zhejiang, China, 310009 China Novartis Investigative Site Beijing, China, 100028 Novartis Investigative Site Beijing, China, 100730 Novartis Investigative Site Shanghai, China, 200003 Novartis Investigative Site Shanghai, China, 200025 Novartis Investigative Site Shanghai, China, 200040 Novartis Investigative Site Shanghai, China, 200127 Collapse << |
| NCT01670526 | Traumatic Brain Injury ... more >> Cognitive Impairment Collapse << | Phase 3 | Completed | - | United States, California ... more >> VA San Diego Healthcare System, San Diego, CA San Diego, California, United States, 92161 United States, Florida Miami VA Healthcare System, Miami, FL Miami, Florida, United States, 33125 James A. Haley Veterans' Hospital, Tampa, FL Tampa, Florida, United States, 33612 United States, Illinois Edward Hines Jr. VA Hospital, Hines, IL Hines, Illinois, United States, 60141-5000 United States, Nebraska Lincoln Community-Based Outpatient Clinic, Lincoln, NE Lincoln, Nebraska, United States, 68510 United States, South Carolina Ralph H. Johnson VA Medical Center, Charleston, SC Charleston, South Carolina, United States, 29401-5799 United States, Texas Michael E. DeBakey VA Medical Center, Houston, TX Houston, Texas, United States, 77030 United States, Utah VA Salt Lake City Health Care System, Salt Lake City, UT Salt Lake City, Utah, United States, 84148 Collapse << |
| NCT01670526 | - | - | Completed | - | - |
| NCT01399125 | - | - | Completed | - | - |
| NCT00423085 | Alzheimer's Disease | Phase 3 | Completed | - | Japan ... more >> Novartis Investigative Site Hokkaido region, Hokkaido, Japan Collapse << |
| NCT00423085 | - | - | Completed | - | - |
| NCT00704301 | Delirium | Phase 4 | Terminated(The study is premat... more >>urely terminated due to a safety issue) Collapse << | - | Netherlands ... more >> Medical Center Leeuwarden Leeuwarden, Friesland, Netherlands, 8901 BR Gelre Hospitals; lukas site Apeldoorn, Gelderland, Netherlands, 7300 DS Medical Center Alkmaar Alkmaar, Noord-Holland, Netherlands, 1800 AM Erasmus Medical Center Rotterdam, Zuid-Holland, Netherlands, 3000 CA University Medical Center Utrecht Utrecht, Netherlands, 3508 GA Diakonessenhuis Utrecht, Netherlands, 3582 KE Collapse << |
| NCT00948766 | - | - | Completed | - | - |
| NCT00428389 | Alzheimer's Disease | Phase 3 | Completed | - | - |
| NCT01602198 | - | - | Terminated(Study revised to us... more >>e a different study medication and patient population.) Collapse << | - | - |
| NCT01529619 | Alzheimer's Disease | Phase 4 | Completed | - | Japan ... more >> Novartis Investigative Site Nagoya-city, Aichi, Japan, 467-8602 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Miyoshi-city, Hiroshima, Japan, 728-0013 Novartis Investigative Site Ohtake, Hiroshima, Japan, 739-0696 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Kamakura-city, Kanagawa, Japan, 247-8533 Novartis Investigative Site Kawasaki-city, Kanagawa, Japan, 216-8511 Novartis Investigative Site Yokohama, Kanagawa, Japan, 241-0811 Novartis Investigative Site Koshi-city, Kumamoto, Japan, 861-1116 Novartis Investigative Site Kyoto-city, Kyoto, Japan, 600-8558 Novartis Investigative Site Kyoto, Japan, 606-0851 Collapse << |
| NCT00948766 | Alzheimer's Disease | Phase 4 | Completed | - | - |
| NCT00428389 | - | - | Completed | - | - |
| NCT00171795 | Traumatic Brain Injury | Phase 3 | Completed | - | - |
| NCT00561392 | - | - | Completed | - | - |
| NCT00748007 | Down Syndrome | Not Applicable | Completed | - | Taiwan ... more >> Department of Medical Genetics, National Taiwan University Hospital Taipei, Taiwan, 100 Collapse << |
| NCT01585272 | - | - | Completed | - | - |
| NCT00561392 | Alzheimer's Disease | Phase 4 | Completed | - | Germany ... more >> Novartis Investigative Site Munich, Germany Collapse << |
| NCT01380288 | Alzheimer's Disease | Not Applicable | Completed | - | Korea, Republic of ... more >> Holy Family Hospital, The Catholic Univerisy of Korea, School of Medicine Bucheon, Korea, Republic of Busan National University Hospital Busan, Korea, Republic of Busan Paik Hospital, Inje University College of Medicine Busan, Korea, Republic of Changwon Fatima Hospital Changwon, Korea, Republic of Daegu Fatima Hospital Daegu, Korea, Republic of Keimyung University School of Medicine Daegu, Korea, Republic of Kyungpook National University School of Medicine Daegu, Korea, Republic of Myongji Hospital, Kwandong University College of Medicine Goyang, Korea, Republic of Dongguk University International Hospital Ilsan, Korea, Republic of National Health Insurance Corporation Ilsan Hospital Ilsan, Korea, Republic of Inha University College of Medicine Incheon, Korea, Republic of Gyeongsang National University College of Medicine Jinju, Korea, Republic of Chonnam National University, Medical School Kwangju, Korea, Republic of Seoul National Unviersity College of Medicine, Clinical neuroscience center, Seoul National Unviersity Bundang Hospital Seongnam, Korea, Republic of The Catholic Univerisy of Korea, School of Medicine Seoul, Korea, Republic of Pusan National University Yangsan Hospital Yangsan, Korea, Republic of Collapse << |
| NCT01084135 | - | - | Completed | - | - |
| NCT01025466 | Alzheimer's Disease | Phase 4 | Completed | - | Korea, Republic of ... more >> Soonchunhyang University Hospital Bucheon, Korea, Republic of, 420-767 The Catholic University of Korea Hospital Bucheon, Korea, Republic of Donga University Hospital Busan, Korea, Republic of, 602-715 Changwon Fatima Hospital Changwon, Korea, Republic of, 641-560 Keimyung University Dongsan Medical Center Daegu, Korea, Republic of, 700-712 Daejun Eulji University Hopistal Daejun, Korea, Republic of, 302-799 Dongguk University Medical Center Goyang, Korea, Republic of, 41-773 Myongji Hospital Goyang, Korea, Republic of, 412-270 Chonnam National University Hospital Gwangju, Korea, Republic of, 501-757 Wonkwang University Hospital Iksan, Korea, Republic of, 570-180 Inha Univeristy Hospital Incheon, Korea, Republic of, 400-711 Gachon University Gil Medical Center Incheon, Korea, Republic of, 405-760 Pusan National University Hospital Pusan, Korea, Republic of, 602-739 Maryknoll Hospital Pusan, Korea, Republic of Bobath Memorial Hospital Seongnam, Korea, Republic of Kyughee University Medical Center Seoul, Korea, Republic of, 130-702 Kangdong Sacred Heart Hospital Seoul, Korea, Republic of, 134-701 Sungkyunkwan University, Samsung Seoul Hospital Seoul, Korea, Republic of, 135-710 Konkuk University Hospital Seoul, Korea, Republic of, 143-729 Hallym University Hospital Seoul, Korea, Republic of, 150-719 Ewha Womans University Hospital Seoul, Korea, Republic of, 158-710 Asan Medical Center Seoul, Korea, Republic of, 431-060 Seoul Eulji Hospital Seoul, Korea, Republic of Seoul Medical Center Seoul, Korea, Republic of Seoul National University Boramae Hospital Seoul, Korea, Republic of Ajou University Hospital Suwon, Korea, Republic of Collapse << |
| NCT01030692 | Cocaine Dependence ... more >> Cocaine Addiction Cocaine Abuse Substance Abuse Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Michael E. DeBakey Veterans Affairs Medical Center Houston, Texas, United States, 77030 Collapse << |
| NCT01084135 | Down Syndrome | Phase 1 Phase 2 | Completed | - | United States, Maryland ... more >> Kennedy Krieger Institute Baltimore, Maryland, United States, 21205 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 Collapse << |
| NCT00622713 | - | - | Completed | - | - |
| NCT00835159 | Delirium Post... more >>operative Cognitive Dysfunction Collapse << | Phase 4 | Completed | - | United States, New York ... more >> NYU Langone Medical Center, Department of Anesthesiology 550 First Avenue, RR-603 New York, New York, United States, 10016 Collapse << |
| NCT00623103 | - | - | Completed | - | - |
| NCT01585272 | Alzheimer's Dementia | Phase 4 | Completed | - | Taiwan ... more >> Novartis Investigative Site Taichung, Taiwan ROC, Taiwan Novartis Investigative Site Taipei, Taiwan, ROC, Taiwan, 112 Novartis Investigative Site Taichung, Taiwan, 40447 Novartis Investigative Site Taipei, Taiwan, 10002 Collapse << |
| NCT00623103 | Parkinson's Disease Dementia | Phase 3 | Completed | - | - |
| NCT01146067 | Healthy | Phase 1 | Completed | - | - |
| NCT00622713 | Alzheimer's Disease | Phase 4 | Completed | - | France ... more >> Novartis Investigative Site Rueil-Malmaison, France Collapse << |
| NCT00835159 | - | - | Completed | - | - |
| NCT01312363 | - | - | Completed | - | Korea, Republic of ... more >> Korea University Ansan Hospital Ansan, Gyeonggi-do, Korea, Republic of, 425-707 Myongji Hospital Goyang-si, Gyeonggi-do, Korea, Republic of, 412-270 Wonkwang University Sanbon Medical Center Gunpo-si, Gyeonggi-do, Korea, Republic of, 435-040 Hanyang University Guri Hospital Guri-si, Gyeonggi-do, Korea, Republic of, 471-701 Bobath Memorial Hospital Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-480 Yong-in Hyoja Geriatric Hospital Yongin-si, Gyeonggi-do, Korea, Republic of Dong-A University Hospital Busan, Korea, Republic of Pusan National University Hospital Busan, Korea, Republic of Hallym University Chunchon Hospital Chunchon, Korea, Republic of Konyang University Hospital Daejeon, Korea, Republic of Inha University Hospital Incheon, Korea, Republic of, 400-711 Jeju National University Hospital Jeju, Korea, Republic of, 690-756 Seoul St. Mary's Hospital Seoul, Korea, Republic of, 137-701 SungAe General Hospital Seoul, Korea, Republic of, 150-051 Chungang University Hospital Seoul, Korea, Republic of, 156-755 Ewha Womans University Hospital Seoul, Korea, Republic of Hanyang University Seoul Hospital Seoul, Korea, Republic of Kyung Hee University Medical Center Seoul, Korea, Republic of Sanggye Paik Hospital Seoul, Korea, Republic of Collapse << |
| NCT02444637 | Alzheimer Disease ... more >> CVA (Cerebrovascular Accident) Collapse << | Phase 4 | Unknown | - | Singapore ... more >> National Neuroscience Institute Recruiting Singapore, Singapore, 308433 Contact: Jocelyn Cheong (65) 63577635 ctru@nni.com.sg Principal Investigator: Nagaendran Kandiah, MRCP;FAMS Collapse << |
| NCT01183806 | Alzheimer Disease | Phase 3 | Completed | - | Brazil ... more >> Ferderal University of Bahia - DINEP Salvador, Bahia, Brazil, 40.110-170 Federal University of Bahia Salvador, Bahia, Brazil, 40110170 Collapse << |
| NCT02989402 | Alzheimer's Disease | Phase 4 | Not yet recruiting | February 3, 2020 | - |
| NCT01073319 | Methamphetamine Dependence ... more >> Substance Abuse Methamphetamine Abuse Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 Collapse << |
| NCT02703636 | Mild to Moderate Alzheimer's D... more >>isease Collapse << | Phase 4 | Completed | - | Japan ... more >> Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-001 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Aizuwakamatsu, Fukushima, Japan, 965-8585 Novartis Investigative Site Tsukuba-city, Ibaraki, Japan, 305-8576 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Sagamihara-city, Kanagawa, Japan, 252-5188 Novartis Investigative Site Kochi-city, Kochi, Japan, 780-0842 Novartis Investigative Site Kurashiki-city, Okayama, Japan, 710-0826 Novartis Investigative Site Osaka-city, Osaka, Japan, 543-8555 Novartis Investigative Site Suita-city, Osaka, Japan, 565 0871 Novartis Investigative Site Kasukabe-city, Saitama, Japan, 344-0036 Novartis Investigative Site Koshigaya-city, Saitama, Japan, 343-0032 Novartis Investigative Site Fuji-city, Shizuoka, Japan Novartis Investigative Site Bunkyo-ku, Tokyo, Japan, 113-8431 Novartis Investigative Site Hachioji-city, Tokyo, Japan, 193-0944 Novartis Investigative Site Shinjuku-ku, Tokyo, Japan, 160-0023 Novartis Investigative Site Niigata, Japan Novartis Investigative Site Okayama, Japan, 710-0813 Novartis Investigative Site Tokyo, Japan, 168-8535 Collapse << |
| NCT01146041 | Healthy | Phase 1 | Completed | - | - |
| NCT02413554 | Delirium | Phase 4 | Completed | - | - |
| NCT00624663 | Rivastigmine Toxicity | Not Applicable | Completed | - | Israel ... more >> Tel Aviv Sourasky Medical Center Tel Aviv, Israel Tasmc Clinical Research Center Tel-Aviv, Israel, 64239 Collapse << |
| NCT02063269 | Alzheimer's Disease | Not Applicable | Unknown | June 2017 | Korea, Republic of ... more >> Seoul Metropolitan Government Seoul National University Boramae Medical Center Seoul, Korea, Republic of, 156-707 Collapse << |
| 靶点 | Description | IC50 |
|---|---|---|
| AChE | IC50:4.15µM | |
| BuChE | IC50:37nM |
