|(1S,2R)-4-羟基-a-[1-[[2-(4-羟基苯基)乙基]氨基]乙基]苄醇盐酸盐|CsnPharm

CAS No.: 23239-51-2

Ritodrine HCl/盐酸利托君 Catalog No. CSN11850

Synonyms: DU21220 hydrochloride;NSC 291565;DU-21220

Ritodrine HCl activates β-2 adrenergic receptor through binding to β-2 adrenergic receptors on outer membrane of myometrial cell, used to stop premature labor.

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技术信息

生物活性

描述Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist. In treating preterm labour, ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate^[3]. Multivariable analysis showed that the total dose of ritodrine was significantly associated with pulmonary oedema. Consideration of the total dose of ritodrine hydrochloride is helpful in the management of patients with threatened preterm labour in twin pregnancy^[4]. However, long-term tocolysis with intravenous infusion of ritodrine hydrochloride, a betamimetic, can be selected as the first-line tocolytic treatment in Japan^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03298191	Preterm Labor Without Delivery	Phase 4	Recruiting	May 25, 2018	Egypt ... more >> Mohamed Atef Mohamed Recruiting Sohag, Egypt Contact: mohamed mohamed +01005537951 mohammedelksoy@yahoo.com Collapse <<
NCT00679705	Healthy	Phase 1	Completed	-	Belgium ... more >> University Hospital Ghent Ghent, Belgium, 9000 Collapse <<
NCT02538718	Preterm Labor	Not Applicable	Recruiting	-	Korea, Republic of ... more >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110744 Contact: Joong Shin Park, MD PhD Seoul Metropolitan Goverment Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of, 156707 Contact: Byung Jae Kim, M.D, Ph.D. bjkimmd7@snu.ac.kr Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0882 mL
- 15.4409 mL
- 30.8819 mL
- 5 mM
- 0.6176 mL
- 3.0882 mL
- 6.1764 mL
- 10 mM
- 0.3088 mL
- 1.5441 mL
- 3.0882 mL

技术信息

CAS号

23239-51-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H22ClNO3

运输

蓝冰

分子量

323.81

别名

DU21220 hydrochloride;NSC 291565;DU-21220;Utemerin;Ritodrine (hydrochloride);(±)-Ritodrine;Ritodrine Hydrochloride;ST51015115;Pre-Par;Utopar;盐酸利托君

溶解度

DMSO	93.0 mg/mL (287.2 mM)
Water	65.0 mg/mL (200.7 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03298191	Preterm Labor Without Delivery	Phase 4	Recruiting	May 25, 2018	Egypt ... more >> Mohamed Atef Mohamed Recruiting Sohag, Egypt Contact: mohamed mohamed +01005537951 mohammedelksoy@yahoo.com Collapse <<
NCT00679705	Healthy	Phase 1	Completed	-	Belgium ... more >> University Hospital Ghent Ghent, Belgium, 9000 Collapse <<
NCT02538718	Preterm Labor	Not Applicable	Recruiting	-	Korea, Republic of ... more >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110744 Contact: Joong Shin Park, MD PhD Seoul Metropolitan Goverment Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of, 156707 Contact: Byung Jae Kim, M.D, Ph.D. bjkimmd7@snu.ac.kr Collapse <<
NCT03040752	Preterm Birth	Phase 4	Completed	-	Egypt ... more >> Kasr Alainy medical school Cairo, Egypt, 12151 Collapse <<
NCT00290173	Pregnancy	Not Applicable	Completed	-	Croatia ... more >> Department of Obstetrics and Gynecology, University of Zagreb Zagreb, Croatia, 10000 Collapse <<
NCT00290173	Pregnancy	Not Applicable	Completed	-	Croatia ... more >> Department of Obstetrics and Gynecology, University of Zagreb Zagreb, Croatia, 10000 Collapse <<
NCT00679705	Healthy	Phase 1	Completed	-	Belgium ... more >> University Hospital Ghent Ghent, Belgium, 9000 Collapse <<
NCT03298191	Preterm Labor Without Delivery	Phase 4	Recruiting	May 25, 2018	Egypt ... more >> Mohamed Atef Mohamed Recruiting Sohag, Egypt Contact: mohamed mohamed +01005537951 mohammedelksoy@yahoo.com Collapse <<
NCT02538718	Preterm Labor	Not Applicable	Recruiting	-	Korea, Republic of ... more >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110744 Contact: Joong Shin Park, MD PhD Seoul Metropolitan Goverment Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of, 156707 Contact: Byung Jae Kim, M.D, Ph.D. bjkimmd7@snu.ac.kr Collapse <<
NCT03040752	Preterm Birth	Phase 4	Completed	-	Egypt ... more >> Kasr Alainy medical school Cairo, Egypt, 12151 Collapse <<

Ritodrine HCl/盐酸利托君 Catalog No. CSN11850

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