|N-氨基甲酰-2-甲基-4,5-双(甲磺酰)苯甲酰胺|CsnPharm

CAS No.: 187870-78-6

Rimeporide Catalog No. CSN24189

Synonyms: EMD-87580

Rimeporide is a potent and selective NHE1 inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述NHE-1 (sodium-hydrogen exchanger) is a key membrane transporter regulating the intracellular pH, Na⁺ concentration and catalysing the electroneutral counter transport of Na⁺ and H⁺ through the plasma membrane. Rimeporide is a potent and selective NHE-1 inhibitor. It is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent and could therefore be used to treat a broad population of patients with DMD (Duchenne muscular dystrophy). Rimeporide prevented both inflammation and the accumulation of fibrosis in the skeletal muscle and in the heart in mdx mice. Rimeporide prevented hypertrophy, thrombosis and necrosis in the heart of cardiomyopathic hamster. Its cardio-protective effect is most clearly demonstrated by a significant increase in overall survival of treated animals.
动物研究
剂量
Dog: 5 mg/kg^[2] (i.v.); 10 mg/kg^[3] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Dog: 5 mg/kg^[2] (i.v.); 10 mg/kg^[3] (p.o.)
给药途径	p.o.

[1] Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9995 mL
- 14.9977 mL
- 29.9954 mL
- 5 mM
- 0.5999 mL
- 2.9995 mL
- 5.9991 mL
- 10 mM
- 0.3000 mL
- 1.4998 mL
- 2.9995 mL

技术信息

CAS号

187870-78-6

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H15N3O5S2

运输

蓝冰

分子量

333.38

别名

EMD-87580

溶解度

DMSO	185.0 mg/mL (554.9 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Rimeporide Catalog No. CSN24189

靶点选择性

请登录您的专属账户

确认信息