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CAS No.: 592542-60-4
Synonyms: ON-01910 sodium;瑞格色替钠
Rigosertib sodium is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02014051 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research site Nagoya, Aichi, Japan Research site Isehara, Kanagawa, Japan Research site Sendai, Miyagi, Japan Research site Kyoto, Japan Collapse << |
NCT02014051 | - | - | Completed | - | - |
NCT02002936 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research Site Nagoya, Aichi, Japan Research Site Isehara, Kanagawa, Japan Research Site Sendai, Miyagi, Japan Research Site Kyoto, Japan Collapse << |
实验方案
技术信息
CAS号 | 592542-60-4 | 储存条件 |
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分子式 | C21H24NNaO8S | 运输 | 蓝冰 | |
分子量 | 473.47 | 别名 | ON-01910 sodium;瑞格色替钠 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02014051 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research site Nagoya, Aichi, Japan Research site Isehara, Kanagawa, Japan Research site Sendai, Miyagi, Japan Research site Kyoto, Japan Collapse << |
NCT02014051 | - | - | Completed | - | - |
NCT02002936 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research Site Nagoya, Aichi, Japan Research Site Isehara, Kanagawa, Japan Research Site Sendai, Miyagi, Japan Research Site Kyoto, Japan Collapse << |
NCT02000154 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research Site Nagoya, Aichi, Japan Research site Isesaki, Kanagawa, Japan Research Site Sendai, Miyagi, Japan Research Site Kurashiki, Okayama, Japan Research Site Kawagoe, Saitama, Japan Research Site Fukuoka, Japan Research Site Kagoshima, Japan Research Site Kumamoto, Japan Research Site Tokyo, Japan Collapse << |
NCT02000154 | - | - | Completed | - | - |
NCT02002936 | - | - | Completed | - | - |
NCT03495167 | Myelodysplastic Syndrome | Phase 1 | Recruiting | June 2019 | Japan ... more >> Research Site Recruiting Nagoya, Aichi, Japan Research Site Recruiting Maebashi, Gunma, Japan Research Site Recruiting Sapporo, Hokkaido, Japan Research Site Recruiting Kobe, Hyogo, Japan Research Site Recruiting Kurashiki, Okayama, Japan Research Site Recruiting Shinagawa, Tokyo, Japan Research Site Recruiting Fukuoka, Japan Research Site Recruiting Kumamoto, Japan Research Site Recruiting Kyoto, Japan Collapse << |
NCT01700335 | Myelodysplastic Syndrome | Phase 1 | Completed | - | Japan ... more >> Research Site Nagoya, Aichi, Japan Research Site Fukuoka, Japan Research Site Tokyo, Japan Collapse << |
NCT01700335 | - | - | Completed | - | - |
NCT00987584 | - | - | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
NCT00533416 | Myelodysplastic Syndrome (MDS) | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT02783547 | Myelodysplastic Syndrome | Phase 1 | Unknown | June 2017 | Japan ... more >> Research Site Nagoya, Aichi, Japan Research Site Kakamigahara, Gifu, Japan Research Site Sendai, Miyagi, Japan Research Site Shinagawa, Tokyo, Japan Collapse << |
NCT00861328 | Advanced Solid Tumors | Phase 1 | Completed | - | United States, New York ... more >> Albert Einstein Cancer Center The Bronx, New York, United States, 10461 Collapse << |
NCT00861510 | Lymphoma, Mantle-cell ... more >> Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Hairy Cell Waldenstrom Macroglobulinemia Multiple Myeloma Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00867061 | Myelodysplastic Syndrome | Phase 1 Phase 2 | Withdrawn(Mutual decision by s... more >>ite and sponsor because of difficulty recruiting Patients.) Collapse << | September 2010 | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
NCT02562443 | Myelodysplastic Syndrome ... more >> MDS Refractory Anemia With Excess Blasts RAEB Collapse << | Phase 3 | Recruiting | September 2019 | - |
NCT00861783 | Hepatoma Adva... more >>nced Solid Tumor Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse << |
NCT01360853 | Metastatic Pancreatic Adenocar... more >>cinoma Collapse << | Phase 3 | Completed | - | - |
NCT01926587 | Myelodysplastic Syndrome ... more >> Acute Myeloid Leukemia Chronic Myelomonocytic Leukemia Collapse << | Phase 1 Phase 2 | Active, not recruiting | January 2019 | United States, Arizona ... more >> Banner MD Anderson Cancer Center Gilbert, Arizona, United States, 85234 United States, California City of Hope Duarte, California, United States, 91010 Desert Hematology Oncology Medical Group, Inc. Rancho Mirage, California, United States, 92270 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Kansas Cancer Center of Kansas Wichita, Kansas, United States, 67214 United States, Missouri Saint Louis University Saint Louis, Missouri, United States, 63110 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Mount Sinai Medical Center New York, New York, United States, 10029 White Plains Hospital Center for Cancer Care White Plains, New York, United States, 10601 United States, South Carolina Carolina Blood and Cancer Care Associates Rock Hill, South Carolina, United States, 29732 United States, Texas The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin Froedtert Hospital and the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 France Hôpital St. Louis Paris, France, 75475 Collapse << |
NCT00906334 | Myelodysplastic Syndrome | Phase 2 | Completed | - | United States, California ... more >> Stanford Cancer Center Stanford, California, United States, 94305 Collapse << |
NCT00854945 | Myelodysplastic Syndrome ... more >> Acute Myeloid Leukemia Collapse << | Phase 1 Phase 2 | Completed | - | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
NCT00856791 | Ovarian Cancer | Phase 2 | Completed | - | United States, Indiana ... more >> St. Vincent Gynecologic Oncology Indianapolis, Indiana, United States, 46260 Collapse << |
NCT01165905 | Solid Tumor | Phase 1 | Completed | - | United States, California ... more >> Department of Medicine, University of California San Francisco San Francisco, California, United States, 94143 United States, New York Albert Einstein Cancer Center/Montefiore Medical Center The Bronx, New York, United States, 10461 Collapse << |
NCT02730884 | Leukemia Myel... more >>ofibrosis Anemia Splenomegaly Collapse << | Phase 2 | Recruiting | August 2022 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact jcortes@mdanderson.org Collapse << |
NCT00856791 | - | - | Completed | - | - |
NCT02107235 | Head and Neck Neoplasms ... more >> Carcinoma, Squamous Cell Collapse << | Phase 1 | Completed | - | United States, Colorado ... more >> University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Delaware Christiana Care Health Services Newark, Delaware, United States, 19713 United States, New York Montefiore Medical Center The Bronx, New York, United States, 10467 United States, Ohio The Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Collapse << |
NCT01538563 | Solid Tumors ... more >>Advanced Cancer Cancer Neoplasms Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Albert Einstein Cancer Center The Bronx, New York, United States, 10461 Collapse << |
NCT01241500 | Myelodysplastic Syndromes ... more >> MDS RAEB Chronic Myelomonocytic Leukemia Collapse << | Phase 3 | Active, not recruiting | February 2019 | - |
NCT00854646 | Acute Myelocytic Leukemia ... more >> Acute Lymphocytic Leukemia Chronic Myelocytic Leukemia Chronic Lymphocytic Leukemia Myelodysplastic Syndromes Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Mount Sinai Medical Center New York, New York, United States, 10029 Collapse << |
NCT01125891 | Malignant Neoplasmas ... more >> Solid Tumors Collapse << | Phase 1 | Completed | - | United States, Colorado ... more >> University of Colorado Cancer Center Denver, Colorado, United States, 80045 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Collapse << |
NCT02075034 | Myelodysplastic Syndrome | Phase 1 | Suspended(Study suspended befo... more >>re enrollment and treatment of any patients; study potentially will resume after evaluation of results from other studies) Collapse << | November 2019 | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
NCT01584531 | Myelodysplastic Syndrome ... more >> MDS Trisomy 8 Collapse << | Phase 2 | Completed | - | United States, Arizona ... more >> Mayo Clinic Scottsdale, Arizona, United States, 85259 United States, Georgia Winship Cancer Institute, Emory University Atlanta, Georgia, United States, 30322 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, South Carolina Bon Secours St. Francis Hospital Greenville, South Carolina, United States, 29601 Collapse << |
NCT01168011 | Solid Tumor | Phase 1 | Completed | - | United States, Colorado ... more >> University of Colorado at Denver Health and Sciences Denver, Colorado, United States, 80045 Collapse << |
NCT01928537 | Myelodysplastic Syndromes ... more >> Refractory Anemia With Excess Blasts Chronic Myelomonocytic Leukemia Cytopenia Collapse << | Phase 3 | Active, not recruiting | February 2019 | - |
NCT01904682 | Myelodysplastic Syndromes | Phase 2 | Active, not recruiting | February 2019 | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 United States, Colorado Anschutz Cancer Pavilion University of Colorado Aurora, Colorado, United States, 80045 United States, District of Columbia Washington Cancer Institute at Medstar Washington Hospital Center Washington, District of Columbia, United States, 20010 United States, Illinois The University of Chicago Chicago, Illinois, United States, 60637 United States, Maryland Greenbaum Cancer Center University of Maryland Baltimore, Maryland, United States, 21201 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, New York Mount Sinai Medical Center New York, New York, United States, 10029 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Texas The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 France Hôpital Saint-Louis, Service d'Hématologie Paris, IDF, France, 75475 Germany Heinrich Heine Universität Düsseldorf, NRW, Germany, 40225 Universitätsklinikum Köln Köln, NRW, Germany, 50937 Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Dresden, Saxony, Germany, 01307 Collapse << |
NCT01807546 | Head and Neck Squamous Cell Ca... more >>rcinoma Anal Squamous Cell Carcinoma Lung Squamous Cell Carcinoma Cervical Squamous Cell Carcinoma Esophageal Squamous Cell Carcinoma Skin Squamous Cell Carcinoma Penile Squamous Cell Carcinoma Collapse << | Phase 2 | Completed | - | United States, California ... more >> University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 Stanford Cancer Institute Stanford, California, United States, 94305 United States, Colorado University of Colorado School of Medicine Aurora, Colorado, United States, 80045 Denver VA Medical Center-ECHCS Denver, Colorado, United States, 80220 United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States, 48109 United States, New Jersey Veterans Administration New Jersey Health Care System East Orange, New Jersey, United States, 07018 United States, New York Mount Sinai Medical Center New York, New York, United States, 10029 Montefiore Medical Center The Bronx, New York, United States, 10467 United States, Ohio Ohio State University, James Cancer Hospital Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennslvania Abramson Cancer Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas Mary Crowley Cancer Research Center Dallas, Texas, United States, 75201 United States, Virginia Virginia Cancer Specialists, PC Fairfax, Virginia, United States, 22031 Blue Ridge Cancer Care Salem, Virginia, United States, 24153 Collapse << |
NCT01538537 | Advanced Cancer ... more >> Solid Tumors Cancer Neoplasms Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Mount Sinai School of Medicine New York, New York, United States, 10029 Collapse << |
NCT01167166 | Acute Myelocytic Leukemia ... more >> Acute Lymphocytic Leukemia Myeloproliferative Disease Chronic Myeloid Leukemia Collapse << | Phase 1 Phase 2 | Completed | - | United States, Texas ... more >> University of Texas M. D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT01048619 | Myelodysplastic Syndrome | Phase 1 | Completed | - | United States, Florida ... more >> H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 United States, New York Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
NCT02030639 | Healthy | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Research Unit, Inc. Madison, Wisconsin, United States, 53704 Collapse << |
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