|(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(乙酰氧基)-5,6,9,17,19-五羟基-23-甲氧基-2,4,12,16,18,20,22-七甲基-2,7-(环氧十五烷[1,11,13]三亚胺基)萘酚[2,1-b]呋喃-1,11(2H)-二酮钠盐|CsnPharm

CAS No.: 14897-39-3

Rifamycin sodium/利福霉素SV Catalog No. CSN25364

Synonyms: Rifamycin SV sodium;利福霉素钠

Rifamycin sodium (Rifamycin SV monosodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria.

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描述Rifamycin sodium (Rifamycin SV sodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria^[2]. This antibiotic is primarily used against Mycobacterium tuberculosis and Mycobacterium leprae, causative agents of tuberculosis and leprosy, respectively. In these bacteria, rifamycin treatment specifically inhibits the initiation of RNA synthesis by binding to beta-subunit of RNA polymerase. Apart from its activity against the bacteria, rifamycin has also been reported to inhibit reverse transcriptase (RT) of certain RNA viruses^[3]. Twice-daily rifamycin SV MMX® is an effective and well tolerated treatment option for shortening the duration of non-dysenteric traveller's diarrhoea in adults^[4]. Rifamycin SV and rifaximin antibiotics were found to inhibit cytokine and chemokine synthesis from lipopolysaccharide-activated THP-1 monocytes and macrophages. It was also demonstrated, for the first time, that rifamycin SV exerts anti-inflammatory activities in HT-29 colonic epithelial cells. Moreover, rifamycin SV is also very effective in downregulating secretion of inflammatory cytokines from human CD4 T-cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3874 mL
- 6.9371 mL
- 13.8743 mL
- 5 mM
- 0.2775 mL
- 1.3874 mL
- 2.7749 mL
- 10 mM
- 0.1387 mL
- 0.6937 mL
- 1.3874 mL

技术信息

CAS号	14897-39-3	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C37H47NNaO12	运输	蓝冰
分子量	720.76	别名	Rifamycin SV sodium;利福霉素钠

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