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CAS No.: 572924-54-0
Synonyms: MK-8669;Deforolimus;AP23573
Treatment of HT-1080 cells with Deforolimus induces a dose-dependent inhibition of phosphorylation of both S6 and 4E-BP1, with IC50 of 0.2 nM and 5.6 nM, respectively, and leads to a decrease in cell size, an increase in the proportion of cells in the G1 phase of the cell cycle, and inhibition of glucose uptake.
生物活性
靶点 | mTOR IC50:0.2nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00667615 | Hodgkin's Disease ... more >> Lymphoma Collapse << | Phase 1 Phase 2 | Completed | - | United States, New Jersey ... more >> Memorial Sloan Kettering Cancer Center @ BaskingRidge Basking Ridge, New Jersey, United States, 07920 United States, New York Memorial Sloan Kettering Cancer Center @ Suffolk Commack, New York, United States, 11725 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Weill Cornell Medical Center New York, New York, United States Memorial Sloan Kettering Cancer Center @ Phelps Sleepy Hollow, New York, United States, 10591 Collapse << |
NCT01995500 | Coronary Artery Stenosis | Phase 2 | Active, not recruiting | September 2020 | Israel ... more >> Hadassah Hebrew University Medical Center Jerusalem, Israel, 91129 Collapse << |
NCT01243762 | Neoplasms Malignant | Phase 1 | Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse << | - | - |
实验方案
技术信息
CAS号 | 572924-54-0 | 储存条件 |
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分子式 | C53H84NO14P | 运输 | 蓝冰 | |
分子量 | 990.21 | 别名 | MK-8669;Deforolimus;AP23573 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00667615 | Hodgkin's Disease ... more >> Lymphoma Collapse << | Phase 1 Phase 2 | Completed | - | United States, New Jersey ... more >> Memorial Sloan Kettering Cancer Center @ BaskingRidge Basking Ridge, New Jersey, United States, 07920 United States, New York Memorial Sloan Kettering Cancer Center @ Suffolk Commack, New York, United States, 11725 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Weill Cornell Medical Center New York, New York, United States Memorial Sloan Kettering Cancer Center @ Phelps Sleepy Hollow, New York, United States, 10591 Collapse << |
NCT01995500 | Coronary Artery Stenosis | Phase 2 | Active, not recruiting | September 2020 | Israel ... more >> Hadassah Hebrew University Medical Center Jerusalem, Israel, 91129 Collapse << |
NCT01243762 | Neoplasms Malignant | Phase 1 | Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse << | - | - |
NCT01995487 | Coronary Artery Stenosis | Phase 2 | Active, not recruiting | August 2020 | United States, Georgia ... more >> Piedmont Healthcare Atlanta, Georgia, United States, 30309 Belgium ZNA Middelheim Antwerp, Belgium Canada, Nova Scotia Queen Elizabeth II Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 3A7 Israel Hadassah Hebrew University Medical Center Jerusalem, Israel, 91120 Italy San Raffaele Hospital Milan, Italy, 20162 Netherlands Maasstad Ziekenhuis Rotterdam, Netherlands, 3079 DZ Poland PAKS, II Oddzial Kardiologiczny Bielsko-biala, Poland, 43-316 Spain Hospital Meixoeiro Pontevedra, Vigo, Spain, 36200 Collapse << |
NCT01243762 | - | - | Terminated(The study was termi... more >>nated for business reasons and not due to any safety or efficacy concerns related to dalotuzumab.) Collapse << | - | - |
NCT01169532 | Lymphoma Unsp... more >>ecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Fox Chase Cancer Center Rockledge, Pennsylvania, United States, 19046 Collapse << |
NCT02834806 | Stenosis | Not Applicable | Completed | - | Israel ... more >> Sourasky Medical Center Tel Aviv, Israel Collapse << |
NCT00667615 | - | - | Completed | - | - |
NCT00060632 | Tumors Lympho... more >>ma Multiple Myeloma Collapse << | Phase 1 | Completed | - | - |
NCT00060645 | Tumors Lympho... more >>ma Multiple Myeloma Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Cancer Therapy and Research Center, University of Texas Health Center at San Antonio San Antonio, Texas, United States, 78229 Collapse << |
NCT01234857 | Breast Cancer | Phase 2 | Completed | - | - |
NCT02736344 | Heart Disease | Phase 3 | Recruiting | August 2021 | United States, Arizona ... more >> Scottsdale Heart Group Not yet recruiting Scottsdale, Arizona, United States Contact: David Rizik, MD 480-323-3390 davidrizik@aol.com Principal Investigator: David Rizik, MD United States, Michigan Cardiac and Vascular Research Center of Northern Michigan Recruiting Petoskey, Michigan, United States, 49770 Contact: Thomas J Earl, MD 231-487-9185 research@cvrcnm.com Principal Investigator: Thomas J Earl, MD Collapse << |
NCT00087451 | Malignant Glioma ... more >> Glioblastoma Gliosarcoma Collapse << | Phase 1 | Completed | - | United States, Massachusetts ... more >> Center For Neuro-Oncology, Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, North Carolina The Brain Tumor Center at Duke, Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Brain Tumor Institute, The Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT03702608 | Coronary Stenosis | Not Applicable | Not yet recruiting | April 2020 | - |
NCT00086125 | Hematologic Malignancies ... more >> Leukemia Myelodysplastic Syndromes Myeloid Metaplasia Lymphoma Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> University of Chicago Hospitals, Section of Hematology/Oncology Chicago, Illinois, United States, 60637 United States, Missouri Washington University School of Medicine, Siteman Cancer Center, 4921 Parkview Place St. Louis, Missouri, United States, 63110 United States, New Jersey The Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, New York New York Presbyterian Hospital, Weill College of Cornell University New York, New York, United States, 10021 United States, North Carolina Morris Cancer Center - Duke University Medical Center, Adult Bone Marrow Transplant Clinic Durham, North Carolina, United States, 27705 United States, Ohio Gabrail Cancer Center Canton, Ohio, United States, 44718 United States, Pennsylvania Jeane's Hospital of TUHS Philadelphia, Pennsylvania, United States, 19111 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00538239 | Metastatic Soft-Tissue Sarcoma... more >>s Metastatic Bone Sarcomas Collapse << | Phase 3 | Completed | - | - |
NCT00288431 | Cancer Sarcom... more >>a Collapse << | Phase 1 | Completed | - | - |
NCT00110188 | Prostate Cancer | Phase 2 | Completed | - | United States, California ... more >> Louis Warchaw Prostate Cancer Center, Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Massachusetts Beth Israel Deaconess Medical Center/MGH/DFCI Boston, Massachusetts, United States, 02215 United States, Texas The Methodist Hospital Research Institute Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin, Madison, WI Madison, Wisconsin, United States, 53792 Collapse << |
NCT01071304 | Relapsed or Refractory Advance... more >>d Cancer Collapse << | Phase 1 | Completed | - | - |
NCT00770185 | Endometrial Cancer | Phase 2 | Completed | - | Canada, Alberta ... more >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA - Cancer Centre for the Southern Interior Kelowna, British Columbia, Canada, V1Y 5L3 BCCA - Fraser Valley Cancer Centre Surrey, British Columbia, Canada, V3V 1Z2 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 Cancer Centre of Southeastern Ontario at Kingston Kingston, Ontario, Canada, K7L 5P9 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Univ. Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec CHUM - Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 McGill University - Dept. Oncology Montreal, Quebec, Canada, H2W 1S6 Canada, Saskatchewan Allan Blair Cancer Centre Regina, Saskatchewan, Canada, S4T 7T1 Collapse << |
NCT02828917 | de Novo or Restenosis Lesions | Not Applicable | Active, not recruiting | February 2022 | Japan ... more >> Shonan Kamakura General Kamakura-City, Kanagawa, Japan, 247-8533 Collapse << |
NCT01605396 | Breast Neoplasms | Phase 2 | Terminated | - | - |
NCT00818675 | Non-Small Cell Lung Cancer | Phase 2 | Terminated | - | - |
NCT01256268 | Endometrial Cancer ... more >> Ovarian Cancer Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Collapse << |
NCT00739830 | Endometrial Cancer | Phase 2 | Completed | - | - |
NCT01220570 | Breast Cancer | Phase 1 | Completed | - | - |
NCT01295632 | Advanced Cancer | Phase 1 | Completed | - | - |
NCT00122343 | Endometrial Cancer | Phase 2 | Completed | - | - |
NCT00836927 | Advanced Cancers | Phase 2 | Terminated | - | - |
NCT00730379 | Neoplasms | Phase 1 | Completed | - | - |
NCT00736970 | Breast Cancer ... more >> Breast Neoplasms Collapse << | Phase 2 | Completed | - | - |
NCT01431547 | Solid Tumors | Phase 1 | Completed | - | - |
NCT00777959 | Prostate Cancer | Phase 2 | Completed | - | - |
NCT00874731 | Metastatic or Locally Advanced... more >> Cancer. Collapse << | Phase 1 | Completed | - | - |
NCT00093080 | Leiomyosarcoma ... more >> Liposarcoma Osteosarcoma Sarcoma, Soft Tissue Metastases Collapse << | Phase 2 | Completed | - | - |
NCT00781846 | Solid Tumor | Phase 1 | Completed | - | - |
NCT01043887 | Healthy Volunteers ... more >> Hepatic Insufficiency Collapse << | Phase 1 | Completed | - | - |
NCT01010672 | Sarcoma | Phase 2 | Completed | - | - |
NCT00836927 | - | - | Terminated | - | - |
NCT00694083 | Neoplasm | Phase 1 | Completed | - | - |
NCT00704054 | Solid Tumors | Phase 1 | Completed | - | - |
NCT01431534 | Solid Tumors | Phase 1 | Terminated | - | - |
NCT01212627 | Non-Small Cell Lung Cancer | Phase 1 | Terminated(Determination to st... more >>op enrollment made due to funding) Collapse << | - | United States, Rhode Island ... more >> memorial Hospital of Rhode island Pawtucket, Rhode Island, United States, 02860 The Miriam Hospital Providence, Rhode Island, United States, 02906 Collapse << |
NCT00112372 | Cancer | Phase 1 | Completed | - | - |
NCT01296659 | Soft Tissue Sarcoma | Phase 1 | Withdrawn(Principal Investigat... more >>or left institution.) Collapse << | - | United States, Texas ... more >> Cancer Therapy & Research Center at UTHSCSA San Antonio, Texas, United States, 78229 Collapse << |
NCT01380184 | Cancer, Advanced | Phase 1 | Completed | - | - |
NCT01212627 | - | - | Terminated(Determination to st... more >>op enrollment made due to funding) Collapse << | - | - |
靶点 | Description | IC50 |
---|---|---|
mTOR | IC50:0.2nM |
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