|(E)-2-((1'R,6'R,7'S,8a'S)-6'-乙基-2-氧代-3',5',6',7',8',8a'-六氢-2'H-螺[吲哚啉-3,1'-吲哚嗪]-7'-基)-3-甲氧基丙烯酸甲酯|CsnPharm

CAS No.: 76-66-4

Rhyncholphylline/钩藤碱 Catalog No. CSN11841

Synonyms: Mitrinermine;钩藤碱

Rhyncholphylline, an alkaloid isolated and purified from the herbs of Uncaria rhynchophylla., can protect against ischemic damage and glutamate-induced neuronal death, and also inhibit MA impairment in cultured neurons in vitro. Ca2+ channel blocker.

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生物活性

描述Rhynchophylline (Rhy) is a plant-derived indole alkaloid isolated from Uncaria species^[3]. Rhy effectively obstructs the expansive signaling pathways of degenerative diseases, including Alzheimer disease, Parkinson disease, epilepsy and amyotrophic lateral sclerosis, and stimulates neurogenesis. Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes^[4]. Rhy can protect the neuronal cultures against MA (methamphetamine) exposure and promptly attenuate intracellular calcium overload triggered by MA challenge^[5]. Rhy, which is blood-brain barrier permeable, is beneficial to amyloid pathology and regulates multiple molecular pathways^[6]. Rhynchophylline can alleviate asthma through suppressing autophagy in asthma, and that JAK2/STAT3 signal was involved in this effect of rhynchophylline^[7]. Rhy ameliorated MI/R (myocardial ischemia‑reperfusion) injury through the modulation of mitochondrial mechanisms^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6010 mL
- 13.0050 mL
- 26.0099 mL
- 5 mM
- 0.5202 mL
- 2.6010 mL
- 5.2020 mL
- 10 mM
- 0.2601 mL
- 1.3005 mL
- 2.6010 mL

技术信息

CAS号

76-66-4

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H28N2O4

运输

蓝冰

分子量

384.47

别名

Mitrinermine;钩藤碱

溶解度

DMSO	76.0 mg/mL (197.7 mM)

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