CAS No.: 382180-17-8
Pyroxamide Catalog No. CSN15971
Pyroxamide is an inhibitor of histone deacetylase (HDAC) which potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
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生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00042900 Chronic Myeloproliferative Dis... more >>orders Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Precancerous Condition Small Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << Phase 1 Completed - United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << - 参考文献
- [1] Bradner JE, West N, et al. Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.
- [2] Remiszewski SW, Sambucetti LC, et al. Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 382180-17-8 | 储存条件 |
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| 分子式 | C13H19N3O3 | 运输 | 蓝冰 | |
| 分子量 | 265.31 | 别名 |
