|(R,E)-N-(4-((3-氯-4-(吡啶-2-基甲氧基)苯基)氨基)-3-氰基-7-乙氧基喹啉-6-基)-3-(1-甲基吡咯烷-2-基)丙烯酰胺二马来酸盐|CsnPharm

CAS No.: 1397922-61-0

Pyrotinib dimaleate Catalog No. CSN20156

Synonyms: SHR-1258 dimaleate;SHR-1258 Maleate;Pyrotinib maleate

Pyrotinib maleate is an irreversible pan-ErbB receptor tyrosine kinase inhibitor, in patients with HER2-Positive metastatic breast cancer.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Pyrotinib maleate is an irreversible pan-ErbB receptor tyrosine kinase inhibitor, in patients with HER2-Positive metastatic breast cancer.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02500199	Breast Cancer ... more >> Gastric Cancer Solid Tumors NSCLC Collapse <<	Phase 1	Recruiting	March 2020	United States, Florida ... more >> Florida Cancer Specialists Recruiting Sarasota, Florida, United States, 34232 Contact: Manish Patel, MD 941-377-9993 mpatel@flcancer.com Principal Investigator: Manish Patel, MD United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Alice Shaw, MD,Ph.D 617-724-4000 ashaw1@partners.org Principal Investigator: Alice Shaw, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Brian Beardslee 617-632-5638 brian_beardslee@dfci.harvard.edu Principal Investigator: Geoffrey Shapiro, MD United States, Michigan Henry Ford Health System Recruiting Detroit, Michigan, United States, 48202 Contact: Ding Wang 313-916-3721 dwang1@hfhs.org Principal Investigator: Ding Wang, MD United States, Missouri Washington University Recruiting Saint Louis, Missouri, United States, 63110 Contact: Cindy Fogal 314-362-1518 cfogal@wustl.edu Principal Investigator: Saiama Waqar, MD United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Caileigh Mcgoldrick 646-888-4226 Principal Investigator: Bob Li, MD United States, Tennessee Tennessee Oncology Recruiting Nashville, Tennessee, United States, 37203 Contact: Melisa Johnson, MD mjohnson@tnonc.com Principal Investigator: Melissa Johnson, MD United States, Texas South Texas Accelerated Research Therapeutics Completed San Antonio, Texas, United States, 78229 Collapse <<

参考文献

[1] Ma F, Li Q, et al. Phase I Study and Biomarker Analysis of Pyrotinib, a Novel Irreversible Pan-ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer. J Clin Oncol. 2017 May 12:JCO2016696179.
[2] Li X, Yang C, et al. Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2267 mL
- 6.1333 mL
- 12.2666 mL
- 5 mM
- 0.2453 mL
- 1.2267 mL
- 2.4533 mL
- 10 mM
- 0.1227 mL
- 0.6133 mL
- 1.2267 mL

技术信息

CAS号	1397922-61-0	储存条件	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C40H39ClN6O11	运输	蓝冰
分子量	815.22	别名	SHR-1258 dimaleate;SHR-1258 Maleate;Pyrotinib maleate;Pyrotinib;SHR-1258

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02500199

Breast Cancer ... more >> Gastric Cancer Solid Tumors NSCLC Collapse <<

Phase 1

Recruiting

March 2020

United States, Florida ... more >> Florida Cancer Specialists Recruiting Sarasota, Florida, United States, 34232 Contact: Manish Patel, MD 941-377-9993 mpatel@flcancer.com Principal Investigator: Manish Patel, MD United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Alice Shaw, MD,Ph.D 617-724-4000 ashaw1@partners.org Principal Investigator: Alice Shaw, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Brian Beardslee 617-632-5638 brian_beardslee@dfci.harvard.edu Principal Investigator: Geoffrey Shapiro, MD United States, Michigan Henry Ford Health System Recruiting Detroit, Michigan, United States, 48202 Contact: Ding Wang 313-916-3721 dwang1@hfhs.org Principal Investigator: Ding Wang, MD United States, Missouri Washington University Recruiting Saint Louis, Missouri, United States, 63110 Contact: Cindy Fogal 314-362-1518 cfogal@wustl.edu Principal Investigator: Saiama Waqar, MD United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Caileigh Mcgoldrick 646-888-4226 Principal Investigator: Bob Li, MD United States, Tennessee Tennessee Oncology Recruiting Nashville, Tennessee, United States, 37203 Contact: Melisa Johnson, MD mjohnson@tnonc.com Principal Investigator: Melissa Johnson, MD United States, Texas South Texas Accelerated Research Therapeutics Completed San Antonio, Texas, United States, 78229 Collapse <<

Pyrotinib dimaleate Catalog No. CSN20156

靶点选择性

请登录您的专属账户

确认信息