CAS No.: 457081-03-7
Pyridone 6/吡啶酮6 Catalog No. CSN16800
Synonyms: JAK Inhibitor I;CMP 6;Janus-Associated Kinase Inhibitor I
Pyridone 6 is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM) displaying significantly weaker affinities(130 nM to 10 mM) for other protein tyrosine kinases.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01646580 Dermatomycoses Phase 4 Terminated(Low recruitment rat... more >>e. with the final sample primary endpoint could be assessed.) Collapse << - - NCT02061267 Metabolic Syndrome Not Applicable Unknown December 2014 Spain ... more >> Instituto de la Grasa, CSIC Seville, Spain, 41012 Collapse << NCT02632877 Diabetic Foot Ulcer Phase 1 Phase 2 Completed - Mexico ... more >> Molecular Biology and Gene Therapy Institute Guadalajara, Jalisco, Mexico, 44340 Hospital Valentín Gómez Farías Zapopan, Jalisco, Mexico Collapse << - 更多
- 参考文献
- [1] Nakagawa R, Yoshida H, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.
- [2] Pedranzini L, Dechow T, et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 2006 Oct 1;66(19):9714-21.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 457081-03-7 | 储存条件 |
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| 分子式 | C18H16FN3O | 运输 | 蓝冰 | |
| 分子量 | 309.34 | 别名 | JAK Inhibitor I;CMP 6;Janus-Associated Kinase Inhibitor I;JAK Inhibitor;吡啶酮6 |
