CAS No.: 866206-55-5
PRX-08066 maleate Catalog No. CSN19227
Synonyms: PRX-08066 Maleate
PRX-08066 maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Porvasnik SL, Germain S, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72.
- [2] Svejda B, Kidd M, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 866206-55-5 | 储存条件 |
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| 分子式 | C23H21ClFN5O4S | 运输 | 蓝冰 | |
| 分子量 | 517.96 | 别名 | PRX-08066 Maleate |
